James Douglas Crapo

US Patent:

6479477, Nov 12, 2002

Filed:

Apr 23, 1999

Appl. No.:

09/296615

Inventors:

James D. Crapo - Englewood CO
Brian J. Day - Englewood CO
Polivina Jolicia F. Gauuan - Albany NY
Michael P. Trova - Schenectady NY

Assignee:

Duke University - Durham NC
Aeolus Pharmaceuticals, Inc. - Research Triangle Park NC

International Classification:

A61K 5104

US Classification:

514183, 514410, 540145

Abstract:

The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods. Compounds of the invention include those of Formula I.

US Patent:

6544975, Apr 8, 2003

Filed:

Jan 25, 2000

Appl. No.:

09/490537

Inventors:

James D. Crapo - Englewood CO
Brian J. Day - Englewood CO
Michael P. Trova - Schenectady NY
Polivina Jolicia F. Gauuan - Albany NY
Douglas B. Kitchen - Schenectady NY
Irwin Fridovich - Durham NC
Ines Batinic-Haberle - Durham NC

Assignee:

National Jewish Medical and Research Center - Denver CO
Aeolus Pharmaceuticals INC - Research Triangle Park NC
Duke University - Durham NC

International Classification:

A61K 31409

US Classification:

514185, 514365, 514383, 514397, 514406, 514410, 540145

Abstract:

The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.

US Patent:

6900026, May 31, 2005

Filed:

Nov 9, 2001

Appl. No.:

10/039869

Inventors:

Douglas C. Wallace - Atlanta GA, US
Simon Melov - Atlanta GA, US
James D. Crapo - Cherry Hills Village CO, US
Brian J. Day - Englewood CO, US

Assignee:

Duke University - Durham NC
Emory University - Atlanta GA

International Classification:

C12Q001/34

US Classification:

435 18, 424 92

Abstract:

The present application describes methods for the testing of compounds of potential usefulness as therapeutic antioxidants and/or as therapeutic free radical scavengers. The animal model for testing such compounds is the Sod2CJE homozygous Manganese Superoxide Dismutase-deficient mouse. When pups of these mice are treated with certain antioxidants, they survive past about 7 days of age, and later develop characteristic histological changes and characteristic neurobehavioral disorders. Those treated mice can be further treated with test compounds which may or may not cross the blood brain barrier, and the life span and physical and neurobehavioral characteristics of those mice provide information about the potential utility of the test compound as a therapeutic antioxidant. Phenotypes of the treated mice allow conclusions regarding targeted areas of the brain and thus, applications to particular disorders such as Parkinsonism.

US Patent:

6916799, Jul 12, 2005

Filed:

Jun 14, 2001

Appl. No.:

09/880125

Inventors:

Irwin Fridovich - Durham NC, US
Ines Batinic-Haberle - Durham NC, US
James D. Crapo - Englewood CO, US
Brian J. Day - Englewood CO, US

Assignee:

Duke University - Durham NC
National Jewish Medical and Research Center - Denver CO

International Classification:

C07D487/22
A61K031/409
A61K031/555
A61P011/06

US Classification:

514183, 514184, 514185, 540145

Abstract:

The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.

US Patent:

7189707, Mar 13, 2007

Filed:

Jan 23, 2003

Appl. No.:

10/349171

Inventors:

James D. Crapo - Englewood CO, US
Brian J. Day - Englewood CO, US
Michael P. Trova - Schenectady NY, US
Polivina Jolicia F. Gauuan - Albany NY, US
Douglas B. Kitchen - Schenectady NY, US
Irwin Fridovich - Durham NC, US
Ines Batinic-Haberle - Durham NC, US

Assignee:

National Jewish Medical Research Center - Denver CO
Duke University - Durham NC
Aeolus Sciences, Inc. - Laguna Niguel CA

International Classification:

A61K 31/409

US Classification:

514185, 514365, 514383, 514397, 514406, 514410

Abstract:

The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.

US Patent:

7820644, Oct 26, 2010

Filed:

Jun 16, 2006

Appl. No.:

11/424662

Inventors:

James D. Crapo - Englewood CO, US
Brian J. Day - Englewood CO, US
Michael P. Trova - Schenectady NY, US
Polivina Jolicia F. Gauuan - Albany NY, US
Douglas B. Kitchen - Schenectady NY, US
Irwin Fridovich - Durham NC, US
Ines Batinic-Haberle - Durham NC, US

Assignee:

Aelous Pharmaceuticals, Inc. - Mission Viejo CA

International Classification:

A01N 55/02
A01N 43/36
A61K 31/40
C07B 47/00
C07B 487/22

US Classification:

514185, 514410, 540145

Abstract:

The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.

US Patent:

8217026, Jul 10, 2012

Filed:

Sep 17, 2010

Appl. No.:

12/885198

Inventors:

James D. Crapo - Englewood CO, US
Brian J. Day - Englewood CO, US
Michael P. Trova - Schenectady NY, US
Douglas B. Kitchen - Schenectady NY, US
Irwin Fridovich - Durham NC, US
Ines Batinic-Haberle - Durham NC, US

Assignee:

Aeolus Sciences, Inc. - Mission Viejo CA
National Jewish Health - Durham NC
Duke University - Denver CO

International Classification:

A01N 55/02
A01N 43/36
A61K 31/40
C07B 47/00
C07B 487/22

US Classification:

514185, 514410, 540145

Abstract:

The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.

US Patent:

8546562, Oct 1, 2013

Filed:

Apr 26, 2012

Appl. No.:

13/457232

Inventors:

James D. Crapo - Englewood CO, US
Brian J. Day - Englewood CO, US
Michael P. Trova - Schenectady NY, US
Douglas B. Kitchen - Schenectady NY, US
Irwin Fridovich - Durham NC, US
Ines Batinic-Haberle - Durham NC, US

International Classification:

C07D 487/22
A01N 55/02

US Classification:

540145, 514185, 514410

Abstract:

The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.