James E Doherty

Address:

58 Buffington Ave, Staten Island, NY 10312

Phone:

(347)9389448

VIN:

1N4AL2AP2BN403752

Make:

NISSAN

Model:

ALTIMA

Year:

2011

US Patent:

6809199, Oct 26, 2004

Filed:

Dec 17, 2001

Appl. No.:

10/023231

Inventors:

James B. Doherty - Montvale NJ
John E. Stelmach - Westfield NJ
Meng-Hsin Chen - Westfield NJ
Luping Liu - Lawrenceville NJ
Julianne A. Hunt - Scotch Plains NJ
Rowena D. Ruzck - Old Bridge NJ
Joung L. Goulet - Westfield NJ
David D. Wisnoski - Somerset NJ
Swaminathan Ravi Natarajan - Edison NJ
Kathleen M. Rupprecht - Cranford NJ
Jianming Bao - Scotch Plains NJ
Shouwu Miao - Edison NJ
Xingfang Hong - Westfield NJ
Peter J. Sinclair - Scotch Plains NJ
Florida Kallashi - Yonkers NY

Assignee:

Merck Co., Inc. - Rahway NJ

International Classification:

C07D23972

US Classification:

544256, 546122

Abstract:

Compounds described by the chemical formula (I) or a pharmaceutically acceptable salt thereof: are inhibitors of p38 useful in the treatment of inflammatory diseases such as arthritis.

US Patent:

7196082, Mar 27, 2007

Filed:

Oct 14, 2003

Appl. No.:

10/684990

Inventors:

James B. Doherty - Montvale NJ, US
Meng-Hsin Chen - Westfield NJ, US
Luping Liu - Plainsboro NJ, US
Swaminathan R. Natarajan - Scotch Plains NJ, US
Robert M. Tynebor - Woodbridge NJ, US

Assignee:

Merck & Co. Inc. - Rahway NJ

International Classification:

A61K 31/5375
A61K 31/44
A61K 31/416
C07D 231/56
C07D 413/06

US Classification:

5142352, 544106, 544111, 544132, 544140, 5462681, 5462757, 5483561, 5483611, 5483625, 5142312, 5142335, 514339, 514406

Abstract:

This invention relates to potent potassium channel blocker compounds of Formula I or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.

US Patent:

7196095, Mar 27, 2007

Filed:

Jun 21, 2002

Appl. No.:

10/477367

Inventors:

Tesfaye Biftu - Westfield NJ, US
Richard Beresis - Matawan NJ, US
Richard Berger - Cranford NJ, US
Steven L. Colletti - Princeton Junction NJ, US
James B. Doherty - Montvale NJ, US
Dennis D. Feng - Branchburg Township NJ, US
Dennis M. Schmatz - Cranford NJ, US
Xiaoxia Qian - New York NY, US
David A. Claremon - Maple Glen PA, US
Nigel J. Liverton - Harleysville PA, US
Charles J. McIntyre - Lansdale PA, US
Ernest W. Kovacs - Weehawken NJ, US

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C07D 403/04
C07D 403/14
C07D 417/04
C07D 417/14
A61K 31/506
A61P 19/02

US Classification:

514275, 514243, 5142591, 544331, 544184, 544281

Abstract:

Compounds of formula (I) and pharmaceutically acceptable salts thereof are useful in the treatment of cytokine mediated diseases such as arthritis and in the treatment and/or prevention of protozoal diseases such as coccidiosis.

US Patent:

7314873, Jan 1, 2008

Filed:

Jun 6, 2003

Appl. No.:

10/517754

Inventors:

James B. Doherty - Montvale NJ, US
Swaminathan R. Natarajan - Scotch Plains NJ, US
John E. Stelmach - Westfield NJ, US

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 31/5377
A61K 31/491
A61K 31/519
C07D 413/14
C07D 471/14
C07D 487/14
C07D 213/26
C07D 213/30

US Classification:

5142345, 5142641, 51425214, 544279, 544117, 546303, 546334

Abstract:

Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof: (I) are inhibitors of p38 and are useful in the treatment of inflammation such as in the treatment of rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic conditions; inflamed joints, eczema, psoriasis or other inflammatory skin conditions such as sunburn; inflammatory eye conditions including conjunctivitis; pyresis, pain and other conditions associated with inflammation.

US Patent:

7410992, Aug 12, 2008

Filed:

Aug 31, 2004

Appl. No.:

10/569921

Inventors:

Meng Hsin Chen - Westfield NJ, US
James B. Doherty - Montvale NJ, US
Luping Liu - Plainsboro NJ, US
Swaminathan Natarajan - Scotch Plains NJ, US
Robert M. Tynebor - Woodbridge NJ, US

Assignee:

Merck & Co. Inc. - Rahway NJ

International Classification:

A61K 31/416
C07D 231/54

US Classification:

514406, 5483581, 5483601, 5483611, 5483615, 514403

Abstract:

This invention relates to potent potassium channel blocker compounds of Formula (I) or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans, or a pharmaceutically acceptable salt, in vivo hydrolysable ester, enantiomer, diastereomer or mixture thereof: formula (II) represents Caryl or Cheterocyclyl, said aryl or heterocyclyl optionally substituted with 1-3 groups selected from R; Z represents (CH)PO(OR)(OR*).

US Patent:

7482345, Jan 27, 2009

Filed:

Nov 21, 2006

Appl. No.:

11/602782

Inventors:

Meng-Hsin Chen - Rahway NJ, US
James B. Doherty - Rahway NJ, US
Robert Tynebor - West Point PA, US

International Classification:

A61K 31/53
A61K 31/5025
A61K 31/4985
A61K 31/4375
C07D 401/06
C07D 401/12
C07D 401/10
C07D 401/14
C07D 421/06
C07D 421/10
C07D 421/12
C07D 421/14
C07D 487/04
C07D 471/04

US Classification:

514248, 544349, 544235, 544183, 544224, 546138, 546345, 546 14

Abstract:

Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof:.

US Patent:

7494983, Feb 24, 2009

Filed:

Aug 31, 2004

Appl. No.:

10/570231

Inventors:

Meng Hsin Chen - Westfield NJ, US
James B. Doherty - Montvale NJ, US
Luping Liu - Plainsboro NJ, US
Swaminathan Natarajan - Scotch Plains NJ, US
Robert M. Tynebor - Woodbridge NJ, US

Assignee:

Merck & Co. Inc. - Rahway NJ

International Classification:

A61K 31/675
A61K 31/4439
C07F 9/06

US Classification:

514 80, 514 89, 514338, 514406, 546 22, 546 24, 548113

Abstract:

This invention relates to potent potassium channel blocker compounds of structural Formula I or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.

US Patent:

7528163, May 5, 2009

Filed:

Nov 4, 2003

Appl. No.:

10/530840

Inventors:

James B. Doherty - Montvale NJ, US
Meng-Hsin Chen - Westfield NJ, US
Luping Liu - Plainsboro NJ, US
Swaminathan R. Natarajan - Scotch Plains NJ, US
Robert M. Tynebor - Woodbridge NJ, US

Assignee:

Merck & Co. Inc. - Rahway NJ

International Classification:

A61K 31/415
C07D 231/56

US Classification:

514406, 5483625

Abstract:

This invention relates to potent potassium channel blocker compounds of Formula I or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraocular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.