James Michael Early

US Patent:

62651579, Jul 24, 2001

Filed:

Oct 3, 1997

Appl. No.:

8/943731

Inventors:

Darwin J. Prockop - Philadelphia PA
Loretta D. Spotila - Haddonfield NJ
Constantinos D. Deltas - Nicosia, CY
Larisa Sereda - Philadelphia PA
Andrea Westerhausen Larson - Forrest Hills PA
Michael Pack - Philadelphia PA
Alain Colige - Philadelphia PA
James Early - Upper Darby PA
Jarmo Korkko - Philadelphia PA
Leena Ala-Kokko - Oulu, FI
Susanna Annunen - Oulu, FI
Tero Pihlajamaa - Oulu, FI
Mirko Vuoristo - Oulu, FI
Petteri Paassilta - Oulu, FI

Assignee:

Allegheny University of the Health Sciences - Philadelphia PA
Thomas Jefferson University - Philadelphia PA
University of Oulu - Oulu

International Classification:

C12Q 168
C12P 1934
C07H 2104

US Classification:

435 6

Abstract:

Compositions and methods useful for determining whether a subject has an alteration in a gene encoding a protein chain of Type I or Type IX collagen are described. Novel intronic sequences of five human genes, COL1A1, COL1A2, COL9A1, COL9A2, and COL9A3 are described. Methods of determining the existence in a subject of a pathological condition associated with an altered gene encoding a Type I or Type IX collagen protein chain are provided, wherein such pathological conditions include diseases and disorders which are known to be associated with an altered gene encoding a Type I or Type IX collagen protein chain. Primers, probes, and methods of detecting a genetic predisposition of a subject for a pathological condition associated with an altered gene encoding a Type I or Type IX collagen protein chain are provided. Diseases and disorders for which the methods and compositions of the invention are useful for diagnostic or prognostic purposes include, but are not limited to osteoporosis, osteoarthritis, chondrodysplasia, multiple epiphyseal dysplasia, osteogenesis imperfecta, shortness of stature, scoliosis, low bone density, and degenerative joint disease.

US Patent:

41935284, Mar 18, 1980

Filed:

Apr 11, 1978

Appl. No.:

5/895400

Inventors:

James R. Early - Rosemont PA
Donald C. Lobach - Marlton NJ

Assignee:

Campbell Soup Company - Camden NJ

International Classification:

B23K 108

US Classification:

228 37

Abstract:

A solder delivery apparatus is provided for delivering molten solder to an applicator for soldering the side seams of can bodies moving in a predetermined path. The apparatus comprises an insulated housing having a unitary body portion, a specially designed crucible located in one part of the unitary body portion, a solder gate in fluid communication with the crucible positioned above the floor of the crucible, yet also providing unimpeded gravity delivery of the molten solder therefrom, heating units partially located within the unitary body portion of the housing to uniformly heat the solder gate and to maintain the molten solder therein at a substantially constant temperature throughout, and an applicator, removably mounted to the unitary body of the housing in fluid communication with the solder gate having heaters therein which maintain the molten solder at a substantially constant temperature.