James L Kerwin

US Patent:

6518279, Feb 11, 2003

Filed:

Mar 4, 1999

Appl. No.:

09/262441

Inventors:

William A. Carroll - Evanston IL
Yiyuan Chen - Waukegan IL
Irene Drizin - Wadsworth IL
James F. Kerwin - Grayslake IL
Jimmie L. Moore - Gurnee IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61K 314353

US Classification:

514290, 546 79

Abstract:

Compounds of formula I are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.

US Patent:

20030073850, Apr 17, 2003

Filed:

Feb 17, 2000

Appl. No.:

09/506750

Inventors:

Robert Altenbach - Chicago IL, US
Michael Meyer - Lake Villa IL, US
James Kerwin - Grayslake IL, US
Albert Khilevich - Buffalo Grove IL, US
Teodozyj Kolasa - Lake Villa IL, US
Jeffrey Rohde - Evanston IL, US
William Carroll - Evanston IL, US
Xenia Searle - Grayslake IL, US
Fan Yang - Highwood IL, US

International Classification:

C07D233/54
C07D233/84

US Classification:

548/320100, 548/326500

Abstract:

Compounds of formula I are useful in treating diseases prevented by or ameliorated with agonists. Also disclosed are agonist compositions and a method of activating adrenoceptors in a mammal.

US Patent:

53469070, Sep 13, 1994

Filed:

Feb 16, 1993

Appl. No.:

8/017565

Inventors:

James F. Kerwin - Mundelein IL
Mark W. Holladay - Libertyville IL
Michael J. Bennett - Morton Grove IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61K 3147
C07D21522
C07D20918

US Classification:

514312

Abstract:

Analogs of CCK-tetrapeptides, which analogs have the formula ##STR1## wherein A, B, D, R. sup. 1, R. sup. 2, R. sup. 3, and R. sup. 4 are specifically defined, having activity as CCK antagonists, useful in the treatment or prevention of disorders of the gastrointestinal, central nervous, appetite regulating or pain regulating systems.

US Patent:

60462078, Apr 4, 2000

Filed:

Nov 26, 1997

Appl. No.:

8/980130

Inventors:

Michael D. Meyer - Lake Villa IL
Robert J. Altenbach - Chicago IL
Fatima Z. Basha - Lake Forest IL
William A. Carroll - Evanston IL
Irene Drizin - Wadsworth IL
James F. Kerwin - Grayslake IL
Michael D. Wendt - North Chicago IL
Anthony R. Haight - Wadsworth IL
Weijiang Zhang - Grayslake IL

International Classification:

A61K 31505
C07D23900
C07D47100
C07D48700

US Classification:

514259

Abstract:

The present invention relates to a compound of the formula and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are. alpha. -1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are. alpha. -1 antagonist compositions and a method for antagonizing. alpha. -1 adrenoreceptors and treating BPH.

US Patent:

49719785, Nov 20, 1990

Filed:

Aug 22, 1988

Appl. No.:

7/234525

Inventors:

Alex M. Nadzan - Libertyville IL
James F. Kerwin - Mundelein IL
Chun W. Lin - Wood Dale IL

International Classification:

C07D21522
A61K 3147

US Classification:

514312

Abstract:

A compound of the formula: ##STR1## wherein R. sub. 1 and R. sub. 2 are substituents; R. sub. 6 is hydrogen, loweralkyl, cycloalkyl, loweralkenyl, arylalkyl, (substituted aryl)alkyl, or (heterocyclic)alkyl; B is a bond, an alkylene group, an alkenylene group, an alkadienylene group or a heteroatom containing linking group; D is a substituted acyl group or tetrazolyl; Z is CO, C(S) or S(O). sub. 2 ; Ar is a heterocyclic group; and n is 1 to 3. Also disclosed are a composition and a method for antagonizing CCK, a composition and method for treating or preventing gastrointestinal, central nervous, appetite regulating and pain regulating systems, a composition and method for treating or preventing hyperinsulinemia, methods of making the compounds and intermediates useful in making the compounds.

US Patent:

58918825, Apr 6, 1999

Filed:

Nov 21, 1997

Appl. No.:

8/975979

Inventors:

Michael D. Meyer - Lake Villa IL
Robert J. Altenbach - Chicago IL
Fatima Z. Basha - Lake Forest IL
William A. Carroll - Evanston IL
Irene Drizin - Wadsworth IL
James F. Kerwin - Grayslake IL
Michael D. Wendt - North Chicago IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61K 31505
C07D23900
C07D47100
C07D48700

US Classification:

514267

Abstract:

The present invention relates to a compound of the formula ##STR1## and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are. alpha. -1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are. alpha. -1 antagonist compositions and a method for antagonizing. alpha. -1 adrenoreceptors and tr.

US Patent:

54789460, Dec 26, 1995

Filed:

Nov 30, 1993

Appl. No.:

8/159409

Inventors:

Ferid Murad - Lake Forest IL
James F. Kerwin - Grayslake IL
Lee D. Gorsky - Highland Park IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

C07D26302

US Classification:

548215

Abstract:

Compounds of the formula: ##STR1## useful as regulators of nitric oxide synthase that indirectly modulate cyclic guanosine monophosphate (cGMP), pharmaceutical compositions thereof, for treating disorders of vascular smooth muscles, macrophages, neurons, platelets, bronchial smooth muscles, optic muscles and gastrointestinal smooth muscles, sickle cell anemia and diabetes.

US Patent:

58612947, Jan 19, 1999

Filed:

Jun 7, 1995

Appl. No.:

8/479614

Inventors:

Marlon Daniel Cowart - Round Lake Beach IL
Donald N. Halbert - Libertyville IL
James F. Kerwin - Grayslake IL
Teresa McNally - Gurnee IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

C12N 1500
C12N 1585
C12N 1563
C12N 912

US Classification:

435194

Abstract:

The present invention provides an adenosine kinase protein having an identified structural formula. The identified protein or similar adenosine kinase proteins having residues as claimed and recited herein may be isolated and purified from natural sources or produced by recombinant DNA technology.