James L Kerwin

US Patent:

20120276145, Nov 1, 2012

Filed:

Mar 27, 2012

Appl. No.:

13/431592

Inventors:

Paul Webster - Pasadena CA, US
Siva Wu - South Pasadena CA, US
James Kerwin - Moss Beach CA, US

Assignee:

HOUSE RESEARCH INSTITUTE - Los Angeles CA

International Classification:

G01N 33/573
C40B 40/10
C40B 30/04
G01N 27/72
A61K 39/102
C07K 14/285
C12N 9/52
C12N 9/10
C12N 9/16
C12N 9/12
C12N 9/90
C12N 9/02
A61P 37/04
A61P 31/04
C12Q 1/04

US Classification:

4242561, 435 34, 506 18, 506 9, 435 23, 435 74, 530350, 435220, 435193, 435196, 435194, 435233, 435189

Abstract:

A method of identifying a biofilm that includes non-typeable (NTHi) including a step of screening a sample for the presence of one or more biofilm-specific proteins that are expressed by NTHi. In some cases, an NTHi biofilm-related disease in a subject is diagnosed. Also disclosed are protein microarrays for screening biofilm-specific proteins in a sample, formulations comprising one or more biofilm-specific proteins or fragments thereof, and methods for inducing an immune response in a patient against a biofilm-related infection.

US Patent:

20150293092, Oct 15, 2015

Filed:

Jun 24, 2015

Appl. No.:

14/749504

Inventors:

- Pasadena CA, US
Siva Wu - South Pasadena CA, US
James Kerwin - Moss Beach CA, US

Assignee:

OAK CREST INSTITUTE OF SCIENCE - Pasadena CA

International Classification:

G01N 33/569
A61K 39/102
C07K 14/285

Abstract:

A method of identifying a biofilm that includes non-typeable (NTHi) including a step of screening a sample for the presence of one or more biofilm-specific proteins that are expressed by NTHi. In some cases, an NTHi biofilm-related disease in a subject is diagnosed. Also disclosed are protein microarrays for screening biofilm-specific proteins in a sample, formulations comprising one or more biofilm-specific proteins or fragments thereof, and methods for inducing an immune response in a patient against a biofilm-related infection.