James M Leary

US Patent:

6361545, Mar 26, 2002

Filed:

Sep 22, 1998

Appl. No.:

09/158405

Inventors:

John A. Macoviak - La Jolla CA
James J. Leary - Sunnyvale CA
Wilfred J. Samson - Saratoga CA

Assignee:

Cardeon Corporation - Cupertino CA

International Classification:

A61M 2900

US Classification:

606200, 606151, 606194

Abstract:

A perfusion filter catheter is used to capture potential emboli within the aorta during heart surgery and cardiopulmonary bypass. An expandable embolic filter assembly having fine filter mesh for capturing macroemboli and microemboli is mounted on a catheter shaft having a perfusion lumen with perfusion ports located upstream of the filter. The embolic filter assembly can be actively or passively deployed within the ascending aortic. An optional outer tube covers the embolic filter assembly to prevent premature deployment. Radiopaque markers, sonoreflective markers and/or an aortic transillumination system are provided to monitor the position of the catheter and the deployment state of the embolic filter assembly. The embolic filter assembly is configured to maximize the effective filter surface area when deployed. Embolic filter assembly configurations described include an elongated cone, a frustum of a cone, a trumpet-shape, a modified trumpet-shape, and helically, circumferentially and longitudinally convoluted shapes, as well as configurations having standoff members for centering the filter and holding the filter mesh away from the aortic walls when deployed.

US Patent:

6508777, Jan 21, 2003

Filed:

May 6, 1999

Appl. No.:

09/306555

Inventors:

John Macoviak - La Jolla CA
Wilfred J. Samson - Saratoga CA
Steve Baker - Sunnyvale CA
James J. Leary - Sunnyvale CA

Assignee:

Cardeon Corporation - Cupertino CA

International Classification:

A61M 3700

US Classification:

604 401, 604 611, 604 616, 604 8, 604 9, 604 19, 604 9601, 60410101

Abstract:

A circulatory support system and method for circulatory support are described for performing cardiopulmonary bypass using differential perfusion and/or isolated segmental perfusion of the circulatory system. The circulatory support system includes one or more venous cannulae for draining blood from the venous side of the patients circulatory system, one or more arterial cannulae for perfusing the arterial side of the patients circulatory system, and one or more blood circulation pumps connected between the venous cannulae and the arterial cannulae. The arterial cannulae and the venous cannulae of the circulatory support system may take one of several possible configurations. The circulatory support system is configured to segment a patients circulatory system into one or more isolated circulatory loops. The circulatory loops may be isolated from one another and/or from the remainder of the patients circulatory system on the venous side, as well as on the arterial side, for isolated closed loop circulatory support of separate organ systems. The circulatory support system is suitable for use in minimally-invasive cardiac surgery, using thoracoscopic, port-access or minithoracotomy techniques, or for standard open-chest cardiac surgery.

US Patent:

6669674, Dec 30, 2003

Filed:

May 8, 2000

Appl. No.:

09/566859

Inventors:

John A. Macoviak - La Jolla CA
Wilfred J. Samson - Saratoga CA
Lynn M. Thompson - Palo Alto CA
James J. Leary - Sunnyvale CA

Assignee:

Cardeon Corporation - Cupertino CA

International Classification:

A61M 2500

US Classification:

604264, 604104

Abstract:

The present invention discloses a multi-access cannula for use in a variety of surgical procedures, particularly for use in the course of performing conventional open-chest and peripheral access cardiopulmonary bypass (CPB). The multi-access cannula is capable of being inserted through a single puncture site with a percutaneous tip. At the appropriate depth of insertion, a closure seal may be engaged at the point of entry to secure the positioning of the cannula and prevent leakage of blood from the incision. Once the cannula is at the appropriate position the cannula provides a multiplicity of procedural options for the surgeon. For example, when approaching through the ascending aorta, the multi-access cannula enables the simultaneous passage of various fluids and multiple catheters or instruments in opposing directions within the lumen of the aortic arch through a single insertion site.

US Patent:

6695864, Feb 24, 2004

Filed:

Jul 3, 2001

Appl. No.:

09/898302

Inventors:

John A. Macoviak - La Jolla CA
Wilfred J. Samson - Saratoga CA
James J. Leary - Sunnyvale CA
Brady D. Esch - San Jose CA

Assignee:

Cardeon Corporation - Cupertino CA

International Classification:

A61M 2900

US Classification:

606200, 606194

Abstract:

An aortic shunt apparatus and methods for cerebral embolic protection are described for isolating the aortic arch vessels from the aortic lumen, for selectively perfusing the arch vessels with a fluid and for redirecting blood flow within the aortic lumen and any potential embolic materials carried in the blood through a shunt past the isolated arch vessels. The perfusion shunt apparatus may be mounted on a catheter or cannula for percutaneous introduction or for direct insertion into the aorta. The perfusion shunt apparatus has application for protecting a patient from embolic stroke and hypoperfusion during cardiopulmonary bypass or cardiac surgery and also for selectively perfusing the cerebrovascular circulation with oxygenated blood or with neuroprotective fluids in the presence of risk factors, such as head trauma or cardiac insufficiency. The perfusion shunt apparatus will also find application for selective perfusion of other organ systems within the body.

US Patent:

20020161394, Oct 31, 2002

Filed:

Mar 26, 2002

Appl. No.:

10/108245

Inventors:

John Macoviak - La Jolla CA, US
James Leary - Sunnyvale CA, US
Wilfred Samson - Saratoga CA, US

International Classification:

A61M029/00

US Classification:

606/200000

Abstract:

A aortic filter catheter is used to capture potential emboli within the aorta during heart surgery and cardiopulmonary bypass. An expandable embolic filter assembly having fine filter mesh for capturing macroemboli and microemboli is mounted on a catheter shaft having a perfusion lumen with perfusion ports located upstream of the filter. The embolic filter assembly can be actively or passively deployed within the ascending aortic. The embolic filter assembly includes an aortic occlusion device, which may be a toroidal balloon, an expandable balloon or a selectively deployable external catheter flow control valve. The combined device allows percutaneous transluminal administration of cardiopulmonary bypass and cardioplegic arrest with protection from undesirable embolic events.

US Patent:

20030138350, Jul 24, 2003

Filed:

Nov 27, 2002

Appl. No.:

10/306274

Inventors:

John MacOviak - La Jolla CA, US
Wilfred Samson - Saratoga CA, US
Steve Baker - Sunnyvale CA, US
James Leary - Sunnyvale CA, US

International Classification:

A61M001/14
A61M037/00
A61M001/34

US Classification:

422/045000, 604/004010, 604/006130, 604/006160

Abstract:

A circulatory support system and method for circulatory support are described for performing cardiopulmonary bypass using differential perfusion and/or isolated segmental perfusion of the circulatory system. The circulatory support system includes one or more venous cannulae for draining blood from the venous side of the patient's circulatory system, one or more arterial cannulae for perfusing the arterial side of the patient's circulatory system, and one or more blood circulation pumps connected between the venous cannulae and the arterial cannulae. The arterial cannulae and the venous cannulae of the circulatory support system may take one of several possible configurations. The circulatory support system is configured to segment a patient's circulatory system into one or more isolated circulatory loops. The circulatory loops may be isolated from one another and/or from the remainder of the patient's circulatory system on the venous side, as well as on the arterial side, for isolated closed loop circulatory support of separate organ systems. The circulatory support system is suitable for use in minimally-invasive cardiac surgery, using thoracoscopic, port-access or minithoracotomy techniques, or for standard open-chest cardiac surgery.

US Patent:

6139517, Oct 31, 2000

Filed:

Dec 14, 1998

Appl. No.:

9/212580

Inventors:

John A. Macoviak - La Jolla CA
Wilfred J. Samson - Saratoga CA
James J. Leary - Sunnyvale CA
Brady D. Esch - San Jose CA

Assignee:

Cardeon Corporation - Cupertino CA

International Classification:

A61M 500
A61M 2900

US Classification:

604 8

Abstract:

A perfusion shunt apparatus and methods are described for isolating and selectively perfusing a segment of a patient's cardiovascular system and for directing circulatory flow around the isolated segment. An aortic perfusion shunt apparatus is configured for deployment within a patient's aortic arch and methods are described for isolating the aortic arch vessels from the aortic lumen, for selectively perfusing the arch vessels with a fluid and for directing blood flow within the aortic lumen through a shunt past the isolated arch vessels. The perfusion shunt apparatus may be mounted on a catheter or cannula for percutaneous introduction or for direct insertion into a circulatory vessel, such as the aorta. The perfusion shunt apparatus has application for protecting a patient from embolic stroke or hypoperfusion during cardiopulmonary bypass or cardiac surgery and also for selectively perfusing the cerebrovascular circulation with oxygenated blood or with neuroprotective fluids in the presence of risk factors, such as head trauma or cardiac insufficiency. The perfusion shunt apparatus will also find application for selective perfusion of other organ systems within the body.

US Patent:

62545639, Jul 3, 2001

Filed:

Mar 20, 2000

Appl. No.:

9/532660

Inventors:

John A. Macoviak - La Jolla CA
Wilfred J. Samson - Saratoga CA
James J. Leary - Sunnyvale CA
Brady D. Esch - San Jose CA

Assignee:

Cardeon Corporation - Cupertino CA

International Classification:

A61M 500
A61M 2900

US Classification:

604 8

Abstract:

A perfusion shunt apparatus and methods are described for isolating and selectively perfusing a segment of a patient's cardiovascular system and for directly circulatory flow around the isolated segment. An aortic perfusion shunt apparatus is configured for deployment within a patient's aortic arch and methods are described for isolating the aortic arch vessels from the aortic lumen, for selectively perfusing the arch vessels with a fluid and for directly blood flow within the aortic lumen through a shunt past the isolated arch vessels. The perfusion shunt apparatus may be mounted on a catheter or cannula for percutaneous introduction or for direct insertion into a circulatory vessel, such as the aorta. The perfusion shunt apparatus has application for protecting a patient from embolic stroke or hypoperfusion during cardiopulmonary bypass or cardiac surgery and also for selectively perfusing the cerebrovascular circulation with oxygenated blood or with neuroprotective fluids in the presence of risk factors, such as head trauma or cardiac insufficiency. The perfusion shunt apparatus will also find application for selective perfusion of other organ systems within the body.