James M Mcgreevy

US Patent:

6905884, Jun 14, 2005

Filed:

Jun 15, 2004

Appl. No.:

10/866988

Inventors:

Charles B. Grissom - Salt Lake City UT, US
Frederick G. West - Salt Lake City UT, US
James McGreevy - Salt Lake City UT, US
Joel S. Bentz - Salt Lake City UT, US
Michelle J. Cannon - Price UT, US

Assignee:

University of Utah Research Foundation - Salt Lake City UT

International Classification:

G01N033/567
A61K031/70

US Classification:

436503, 514 52, 536 2644

Abstract:

The present invention relates to fluorescent cobalamins and uses of these compounds. More particularly, this invention relates to fluorescent cobalamins that comprise a fluorescent, phosphorescent, luminescent or light-producing compound covalently linked to cobalamin. These fluorescent cobalamins can be used to as diagnostic and prognostic markers (a) to distinguish cancer cells and tissues from healthy cells and tissues, including identifying lymph nodes containing cancer cells, and (b) to determine if an individual will respond positively to chemotherapy using cobalamin-therapeutic bioconjugates.

US Patent:

8140141, Mar 20, 2012

Filed:

May 17, 2006

Appl. No.:

11/436878

Inventors:

James McGreevy - Salt Lake City UT, US
Charles B. Grissom - Salt Lake City UT, US
Ronald M. Jones - Salt Lake City UT, US

Assignee:

University of Utah Research Foundation - Salt Lake City UT

International Classification:

A61B 5/00

US Classification:

600317, 600300, 600310, 607 88

Abstract:

An apparatus is provided that includes a light-emitting component, a light-detecting component, a lock-in amplifier, a frequency generator that is operatively linked to the lock-in amplifier and the light-emitting component, a speaker capable of emitting an audio signal wherein the output audio signal varies depending on the detected fluorescence in the sample, and a visible output of relative fluorescent intensity where the visible output varies depending on the detected fluorescence in the sample. The apparatus may also include a laser that is operatively coupled to the lock-in amplifier through a control switch, and focusing lens or an additional type of filter such as an interference filter, a short-pass filter, a notch filter, a long-pass filter or an infrared filter. The apparatus may be used to identify and/or to remove fluorescent or non-fluorescent material from a sample. Associated methods are also disclosed.

US Patent:

20020192683, Dec 19, 2002

Filed:

Mar 15, 2002

Appl. No.:

10/097646

Inventors:

Charles Grissom - Salt Lake City UT, US
Frederick West - Salt Lake City UT, US
James McGreevy - Salt Lake City UT, US
Joel Bentz - Salt Lake City UT, US
Michelle Cannon - Price UT, US

International Classification:

C12Q001/68
C07H023/00

US Classification:

435/006000, 536/026440

Abstract:

The present invention relates to fluorescent cobalamins and uses of these compounds. More particularly, this invention relates to fluorescent cobalamins that comprise a fluorescent, phosphorescent, luminescent or light-producing compound covalently linked to cobalamin. These fluorescent cobalamins can be used to as diagnostic and prognostic markers (a) to distinguish cancer cells and tissues from healthy cells and tissues, including identifying lymph nodes containing cancer cells, and (b) to determine if an individual will respond positively to chemotherapy using cobalamin-therapeutic bioconjugates.

US Patent:

20040082863, Apr 29, 2004

Filed:

Sep 15, 2003

Appl. No.:

10/472077

Inventors:

James McGreevy - Salt Lake City UT, US
Charles Grissom - Salt Lake City UT, US
Michelle Cannon - Salt Lake City UT, US

International Classification:

A61B006/00

US Classification:

600/476000

Abstract:

An apparatus that includes a surgical telescopic device having a distal end and a proximal end; a camera coupled to the proximal end of the surgical telescopic device; and a holographic notch filter interposed between the camera and the proximal end of the surgical telescopic device. The camera preferably is a charge-coupled-device camera (“CCD camera”). The apparatus may also include a focusing lens or an alternative type of filter such as a long-pass filter or an infrared filter. The surgical telescopic device may be used by illuminating the material with non-white light and detecting the emitted fluorescence, phosphorescence or luminescence.

US Patent:

20120041305, Feb 16, 2012

Filed:

Apr 21, 2010

Appl. No.:

13/265456

Inventors:

Charles B. Grissom - Salt Lake City UT, US
James M. McGreevy - Holladay UT, US
Robert Hans Ingemar Andtbacka - Salt Lake City UT, US

Assignee:

THE UNIVERSITY OF UTAH RESEARCH FOUNDATION - Salt Lake City UT

International Classification:

A61B 6/00

US Classification:

600431

Abstract:

The present invention relates generally to the field of fluorescent dyes as a system useful for surgery imaging. More particularly, the present invention relates to systems, methods and kits for exciting fluorescent, phosphorescent or luminescent molecules with light from a light source and detecting the relative fluorescent, phosphorescent, or luminescent light intensity emitted from the fluorescent, phosphorescent, or luminescent molecule. Such systems may be applied as mapping agents for various surgical techniques, such as for cancer surgeries and biopsies.

US Patent:

20120179030, Jul 12, 2012

Filed:

Mar 20, 2012

Appl. No.:

13/425255

Inventors:

James McGreevy - Salt Lake City UT, US
Charles B. Grissom - Salt Lake City UT, US
Ronald M. Jones - Salt Lake City UT, US

Assignee:

UNIVERSITY OF UTAH RESEARCH FOUNDATION - Salt Lake City UT

International Classification:

A61B 5/05
B26B 7/00
A61B 1/00
H05B 7/18
G01J 1/42
G01J 1/04

US Classification:

600427, 250216, 25022711, 600104, 219383, 302721

Abstract:

An apparatus is provided that includes a light-emitting component, a light-detecting component, a lock-in amplifier, a frequency generator that is operatively linked to the lock-in amplifier and the light-emitting component, a speaker capable of emitting an audio signal wherein the output audio signal varies depending on the detected fluorescence in the sample, and a visible output of relative fluorescent intensity where the visible output varies depending on the detected fluorescence in the sample. The apparatus may also include a laser that is operatively coupled to the lock-in amplifier through a control switch, and focusing lens or an additional type of filter such as an interference filter, a short-pass filter, a notch filter, a long-pass filter or an infrared filter. The apparatus may be used to identify and/or to remove fluorescent or non-fluorescent material from a sample. Associated methods are also disclosed.