James N Michaels

US Patent:

6953692, Oct 11, 2005

Filed:

Dec 18, 2001

Appl. No.:

10/029779

Inventors:

Rudiger Heidemann - Emeryville CA, US
Mokhtar Mered - Orinda CA, US
James D. Michaels - Oakland CA, US
Konstantin Konstantinov - Walnut Creek CA, US

Assignee:

Bayer Pharmaceuticals Corporation - West Haven CT

International Classification:

C12N005/00

US Classification:

435383, 4353033, 4353051, 4353052, 435325, 435352, 435358, 4352891

Abstract:

A device and method for seed-train expansion of a source of mammalian cells and their use in production of proteins expressed by the cells comprising the use of a dedicated inoculation bioreactor for expanding the cells prior to the transfer to a production bioreactor is disclosed. The novel inoculation bioreactor is designed to facilitate an improved method of mammalian cell seed-train expansion, and is distinguished by the presence of an “inoculation well” which communicates with the interior of the bioreactor and which facilitates the growth of mammalian cells for commercial seed-train expansion. The method comprises adding the cryopreserved cells to media within the inoculation well of the inoculation bioreactor, enabling the cells to grow to a predetermined concentration within the inoculation well by monitoring and adjusting the condition of the media and environment, and thereafter incrementally increasing the volume of the media within the reactor so that optimal cell growth is maintained.

US Patent:

7560559, Jul 14, 2009

Filed:

Apr 12, 2004

Appl. No.:

10/553069

Inventors:

Jun-Hong Chou - Blue Bell PA, US
Michael B. Gentzler - Wayne PA, US
James N. Michaels - Perkasie PA, US
Cynthia Bazin - Saint-Hubert, CA
Sophie-Dorothee Clas - Montreal, CA
Chad Dalton - St-Lazare, CA
Michael Guojie Wu - Edison NJ, US

Assignee:

Merck & Co., Inc. - Rahway NJ
Merck Frosst Canada & Co. - Quebec

International Classification:

C07D 215/38
A61K 31/44

US Classification:

546171, 514311, 514313

Abstract:

The invention provides novel polymorphic form of montelukast sodium, as well as methods of using and pharmaceutical compositions containing saud novel form. Also provided are montelukast sodium: acetonitrile solvates, which are intermediates in the formation of crystalline montelukast sodium.

US Patent:

7845041, Dec 7, 2010

Filed:

Feb 21, 2007

Appl. No.:

11/677433

Inventors:

John J. Gatzemeyer - Hillsborough NJ, US
Eduardo J. Jimenez - Manalapan NJ, US
Robert Riebe - Minneapolis MN, US
James E. Michaels - Downers Grove IL, US
Eugene Eighmy - Birmingham AL, US
Evan Ward - Chicago IL, US

Assignee:

Colgate-Palmolive Company - New York NY

International Classification:

A46B 15/00

US Classification:

15105, 151671

Abstract:

A toothbrush includes a storage unit having an input, a memory for storing audio signals received via the input. The unit can have an output for transmitting or playing the stored audio signals. A variety of different constructions of storage unit and toothbrush configurations are described, each creating an environment that makes tooth brushing enjoyable.

US Patent:

8075315, Dec 13, 2011

Filed:

Dec 13, 2006

Appl. No.:

11/610248

Inventors:

John J. Gatzemeyer - Hillsborough NJ, US
Eduardo J. Jimenez - Manalapan NJ, US
Robert Riebe - Minneapolis MN, US
Evan Ward - Chicago IL, US
Paul Fair - Denver CO, US
James E. Michaels - Lombard IL, US
Kevin Connor - Jackson NJ, US

Assignee:

Colgate-Palmolive Company - New York NY

International Classification:

G09B 19/00
A63F 13/00
A46B 15/00

US Classification:

434238, 434118, 434236, 434308, 463 1, 15105

Abstract:

An oral care implement has an interactive display that displays images representing oral care regions of the mouth. The user can interact with the display by playing a game, which can relate to oral care. An oral care implement has a plurality of lighted segments that can be sequentially illuminated to indicate a recommended brushing sequence. The lighted segments can be shaped and/or labeled to indicate particular oral care regions of the mouth.

US Patent:

8201295, Jun 19, 2012

Filed:

Feb 16, 2007

Appl. No.:

11/676050

Inventors:

John J. Gatzemeyer - Hillsborough NJ, US
Eduardo J. Jimenez - Manalapan NJ, US
Robert Riebe - Minneapolis MN, US
Paul Fair - Denver CO, US
James E. Michaels - Downers Grove IL, US
Evan Ward - Chicago IL, US

Assignee:

Colgate-Palmolive Company - New York NY

International Classification:

A46B 13/02
A61C 17/22

US Classification:

15 221, 15105

Abstract:

An oral care implement includes a display and/or a plurality of other lighted regions, together with an element for inducing motion in a head region. The display and/or lights are used to provide instructions to the user regarding a periodically-performed oral care regimen. The motion-inducing element can be pulsed or otherwise selectively activated to signal different intervals in the regimen. Upon successful conclusion of the oral care regimen, the lights and/or display and the motion-inducing element are used to provide a game or other entertainment to the user.

US Patent:

55633145, Oct 8, 1996

Filed:

May 25, 1995

Appl. No.:

8/423626

Inventors:

Pradyot A. Agaskar - Hopewell NJ
Robert K. Grasselli - Chadds Ford PA
James N. Michaels - Neshanic Station NJ
P. Thomas Reischman - Lambertville NJ
David L. Stern - Lawrenceville NJ
John G. Tsikoyiannis - Princeton NJ

International Classification:

C07C 100
C07C 5327

US Classification:

585654

Abstract:

There is provided a process for the net catalytic oxidative dehydrogenation of alkanes to produce alkenes. The process involves simultaneous equilibrium dehydrogenation of alkanes to alkenes and combustion of the hydrogen formed to drive the equilibrium dehydrogenation reaction further to the product alkenes. In the present reaction, the alkane feed is dehydrogenated over an equilbrium dehydrogenation catalyst in a first reactor, and the effluent from the first reactor is then passed into a second reactor containing a reducible metal oxide which serves to selectively combust hydrogen in an oxidation/reduction (REDOX) reaction. This particular mode of operation is termed a separate reactor, REDOX mode.

US Patent:

51911388, Mar 2, 1993

Filed:

Nov 19, 1991

Appl. No.:

7/794560

Inventors:

Scott Han - Lawrenceville NJ
James N. Michaels - Neshanic Station NJ
Robert E. Palermo - Bloomfield NJ
David L. Stern - Yardley PA
Dennis E. Walsh - Richboro PA

Assignee:

Mobil Oil Corp. - Fairfax VA

International Classification:

C07C 100

US Classification:

585500

Abstract:

There is provided a process for converting methane to hydrocarbons having at least two carbon atoms (i. e. higher hydrocarbons). The process involves oxidizing methane with a metal sulfide oxidizing agent. After this conversion of methane, the reduced metal sulfide may be regenerated by oxidation of the reduced metal sulfide.

US Patent:

55279791, Jun 18, 1996

Filed:

Apr 17, 1995

Appl. No.:

8/423630

Inventors:

Pradyot A. Agaskar - Lawrenceville NJ
Robert K Grasselli - Chadds Ford PA
James N. Michaels - Neshanic Station NJ
P. Thomas Reischman - Lambertville NJ
David L. Stern - Lawrenceville NJ
John G. Tsikoyiannis - Princeton NJ

Assignee:

Mobil Oil Corporation - Fairfax VA

International Classification:

C07C 5333

US Classification:

585659

Abstract:

There is provided a process for the net catalytic oxidative dehydrogenation of alkanes to produce alkenes. The process involves simultaneous equilibrium dehydrogenation of alkanes to alkenes and combustion of the hydrogen formed to drive the equilibrium dehydrogenation reaction further to the product alkenes. In the present reaction, the alkane feed is dehydrogenated over an equilbrium dehydrogenation catalyst in a first reactor, and the effluent from the first reactor, along with oxygen, is then passed into a second reactor containing a metal oxide catalyst which serves to selectively catalyze the combustion of hydrogen. This particular mode of operation is termed a separate reactor, cofed oxygen mode. The equilibrium dehydrogenation catalyst may comprise platinum and the selective metal oxide combustion catalyst may contain bismuth, antimony, indium, molybdenum, or a mixture thereof.