James S Peck

US Patent:

6884434, Apr 26, 2005

Filed:

Mar 18, 1999

Appl. No.:

09/647290

Inventors:

Walter Muller - Neuwied, DE
James V. Peck - Richmond VA, US

Assignee:

LTS Lohmann Therapie-Systeme AG - Andernach
Aderis Pharmaceuticals, Inc. - Richmond VA

International Classification:

A61K009/14
A61F013/00
A61F013/02
A61L015/16

US Classification:

424487, 424486, 424485, 424484, 424448, 424449

Abstract:

A transdermal therapeutic system, comprising a backing layer inert to the components of the matrix, a self-adhesive matrix layer containing (−)-5,6,7,8-tetrahydro-6-[propyl-[2-(2-thienyl)ethyl]amino]-1-naphthalenol in an effective amount and a protective foil or sheet to be removed prior to use, is characterised by a matrix that is based on a non-aqueous, acrylate-based or silicone-based polymer adhesive system having a solubility of ≧5% (w/w) for (−)-5,6,7,8-tetrahydro-6-[propyl-[2-(2-thienyl)ethyl]-amino]-1-naphthalenol, and said matrix is substantially free of inorganic silicate particulates.

US Patent:

7413747, Aug 19, 2008

Filed:

Oct 31, 2007

Appl. No.:

11/931666

Inventors:

Walter Mueller - Neuwied, DE
James V. Peck - Richmond VA, US

Assignee:

LTS Lohmann Therapie-Systeme AG - Andernach
Schwarz Pharma Limited - Shannon

International Classification:

A61F 13/02
A61F 13/00
A61L 15/16
A61K 9/14

US Classification:

424448, 424449, 424443, 424484, 424485, 424486

Abstract:

A transdermal therapeutic system (TTS) comprises a silicone-based polymer adhesive system having distributed therein (−)-5,6,7,8-tetrahydro-6-[propyl-[2-(2-thienyl)ethyl]amino]-1-naphthalenol free base in an amount of about 5% to 40% by weight. The adhesive system comprises a silicone adhesive and an additive having increased solubility for the active substance, in an amount effective to increase dissolving capacity of the matrix for the active substance.

US Patent:

20050033065, Feb 10, 2005

Filed:

Sep 7, 2004

Appl. No.:

10/936620

Inventors:

Walter Mueller - Neuwied, DE
James Peck - Richmond VA, US

Assignee:

LTS Lohmann Therapie-Systeme AG - Andernach
Aderis Pharmaceuticals, Inc. - Richmond VA

International Classification:

C07D333/12

US Classification:

549074000

Abstract:

A substantially solvent-free matrix layer containing (−)-5,6,7,8-tetrahydro-6-[propyl-[2-(2-thienyl)ethyl]amino]-1-naphthalenol is produced by adding an active substance to an adhesive solution, coating the resultant active substance-containing adhesive solution onto a suitable sheet, and removing the solvents in a drying process to give said substantially solvent-free matrix layer.

US Patent:

20080138389, Jun 12, 2008

Filed:

Oct 31, 2007

Appl. No.:

11/931762

Inventors:

Walter Muller - Neuwied, DE
James V. Peck - Richmond VA, US

International Classification:

A61K 9/70
A61K 31/381
A61P 25/16

US Classification:

424448, 514438, 424449

Abstract:

A substantially solvent-free matrix layer containing (−)-5,6,7,8-tetrahydro--[propyl-[2-(2-thienyl)ethyl]amino]-1-naphthalenol is produced by adding an active substance to an adhesive solution, coating the resultant active substance-containing adhesive solution onto a suitable sheet, and removing the solvents in a drying process to give said substantially solvent-free matrix layer.

US Patent:

52740030, Dec 28, 1993

Filed:

Feb 18, 1992

Appl. No.:

7/837229

Inventors:

James V. Peck - Richmond VA
Gevork Minaskanian - Richmond VA

Assignee:

Whitby Research, Inc. - Richmond VA

International Classification:

A61K 31135
C07C21714
C07C21724

US Classification:

514651

Abstract:

Optically active or racemic compounds are provided having the formula ##STR1## where R. sub. 2, R. sub. 3 and R. sub. 4 are each selected from the group consisting of H and OH with the provision that at least one of R. sub. 2, R. sub. 3 and R. sub. 4 is H, that R. sub. 2 and R. sub. 4 are not both OH; X is oxygen; and R. sub. 1 is selected from the group consisting of ##STR2## wherein Z is oxygen, nitrogen or sulfur, wherein Y is selected from the group consisting of hydroxy, nitro, cyano, azido, amino, acylamino, carboxyamido, trifluoromethyl, sulfate, sulfonamido, halogen, hydrocarbyl and heteroatom-substituted hydrocarbyl radicals, wherein said heteroatoms are selected from the group consisting of halogen, nitrogen, oxygen, sulfur and phosphorus and said hydrocarbyl radicals comprise from 1 to 12 carbon atoms, and a is an integer of from zero to 3. These compounds are capable of binding selectivity of one or more dopamine D. sub. 2 receptors, for instance, in humans.

US Patent:

52833437, Feb 1, 1994

Filed:

Jun 18, 1991

Appl. No.:

7/718342

Inventors:

Margarita L. Dubocovich - Evanston IL
Vithal J. Rajadhyaksha - Mission Viejo CA
James V. Peck - Richmond VA
Atef A. Helmy - Anaheim CA

Assignee:

Whitby Research, Inc. - Richmond VA

International Classification:

C07D20916

US Classification:

548496

Abstract:

This invention relates to novel melatonin derivatives, such as 2-aryl substituted N-acetyltryptamines, having pharmacological activity, e. g. , melatonin antagonist activity, and methods for the synthesis thereof.

US Patent:

57031045, Dec 30, 1997

Filed:

Jul 3, 1996

Appl. No.:

8/674843

Inventors:

James V. Peck - Richmond VA
Gevork Minaskanian - Richmond VA
Mark C. Sleevi - Midlothian VA

Assignee:

Durham Pharmaceuticals LLC - Durham NC

International Classification:

A61K 3141
A61K 3140
C07D27704
C07D26304

US Classification:

514369

Abstract:

Compounds, topical compositions and methods useful for preventing the penetration of toxic chemicals through the skin of a mammal are disclosed. The compounds of the invention provide an enhanced barrier for the skin of a mammal to further inhibit or decrease the passage of bioactive agents through the skin of a mammal either from the outside environment into the systems of said mammal or from the mammal into the outside environment.

US Patent:

54300568, Jul 4, 1995

Filed:

Feb 23, 1994

Appl. No.:

8/200338

Inventors:

James V. Peck - Richmond VA
Gevork Minaskanian - Richmond VA

Assignee:

Discovery Therapeutics, Inc. - Richmond VA

International Classification:

A61K 3134
C07D30781
C07D30783

US Classification:

514470

Abstract:

Optically active or racemic compounds are provided having the formula ##STR1## where R. sub. 1 is ##STR2## where Y is hydrogen, halogen or C. sub. 1 to C. sub. 6 linear or branched alkyl; R. sub. 6 is C. sub. 1 to C. sub. 4 linear or branched alkyl; X is oxygen or sulfur; a is an integer from zero to 3; and n is an integer from 1 to 4. The compounds are capable of binding selectively to dopamine D. sub. 2 receptors and are useful in treatment of disorders of the central nervous, cardiovascular and endocrine systems, such as intraocular pressure, schizophrenia and Parkinsonism, and for inducing anorexia and weight loss in humans and other mammals.

Address:

8204 Gaylord Rd, Richmond, VA 23229

VIN:

JTMBK32V776014028

Make:

TOYOTA

Model:

RAV4

Year:

2007