James M Prober from Kennett Square, PA, age 79

Resonant Light Scattering Microparticle Methods
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US Patent:

7122384, Oct 17, 2006
Filed:

Nov 5, 2003
Appl. No.:

10/702320
Inventors:

James M. Prober - Wilmington DE, US
Xiumin Cui - Swarthmore PA, US
Rudy J. Dam - Maple Valley WA, US
Edwin R. Hendrickson - Hockessin DE, US
Xueping Jiang - Wilmington DE, US
Michael P. Perry - Landenberg PA, US
Larry Eugene Steenhoek - Wilmington DE, US
Assignee:

E. I. du Pont de Nemours and Company - Wilmington DE
International Classification:

G01N 33/531
US Classification:

436524, 436518, 436525, 436527, 436528, 436164, 436523, 435 71, 356436, 356432, 356523
Abstract:

Microparticle-based analytical methods, systems and applications are provided. Specifically, the use of resonant resonant light scattering as an analytical method for determining either or both a particle's identity and the presence and optionally, the concentration of one or more particular target analytes is described. Applications of these microparticle-based methods in biological and chemical assays are also disclosed.

Nanoparticle Composite-Coated Glass Microspheres For Use In Bioassays
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US Patent:

7572643, Aug 11, 2009
Filed:

Nov 21, 2005
Appl. No.:

11/284155
Inventors:

Kevin Michael Croker - Hockessin DE, US
Michael B. Damore - Wilmington DE, US
Kostantinos Kourtakis - Media PA, US
Michael P. Perry - Landenberg PA, US
James M. Prober - Wilmington DE, US
Paul Douglas Stull - Wilmington DE, US
Assignee:

E. I. du Pont de Nemours and Company - Wilmington DE
International Classification:

G01N 33/551
G01N 33/552
G01N 33/553
US Classification:

436524, 435 5, 435 6, 435 72, 435 721, 435 732, 435 75, 436525, 436527
Abstract:

A microsphere for use in a bioassay comprising a glass core coated with a nanoparticle composite comprising a bioactive probe is provided. The nanoparticle composite coating enhances the density of bioprobe loading on the surface of the microspheres, resulting in enhanced dynamic range and sensitivity in bioassays. The particle may be used in detection systems where resonant light scattering properties of the particle are useful.

Microparticle-Based Methods And Systems And Applications Thereof
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US Patent:

20050255523, Nov 17, 2005
Filed:

Jul 25, 2005
Appl. No.:

11/188823
Inventors:

James Prober - Wilmington DE, US
Xiumin Cui - Swarthmore PA, US
Rudy Dam - Maple Valley WA, US
Edwin Hendrickson - Hockessin DE, US
Xueping Jiang - Wilmington DE, US
Michael Perry - Landenberg PA, US
Larry Steenhoek - Wilmington DE, US
International Classification:

C12Q001/68
G01N033/543
US Classification:

435006000, 436518000
Abstract:

Microparticle-based analytical methods, systems and applications are provided. Specifically, the use of resonant resonant light scattering as an analytical method for determining either or both a particle's identity and the presence and optionally, the concentration of one or more particular target analytes is described. Applications of these microparticle-based methods in biological and chemical assays are also disclosed.

Microparticle-Based Methods And Systems And Applications Thereof
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US Patent:

20050255524, Nov 17, 2005
Filed:

Jul 25, 2005
Appl. No.:

11/189063
Inventors:

James Prober - Wilmington DE, US
Xiumin Cui - Swarthmore PA, US
Rudy Dam - Maple Valley WA, US
Edwin Hendrickson - Hockessin DE, US
Xueping Jiang - Wilmington DE, US
Michael Perry - Landenberg PA, US
Larry Steenhoek - Wilmington DE, US
International Classification:

C12Q001/68
G01N033/543
US Classification:

435006000, 436518000
Abstract:

Microparticle-based analytical methods, systems and applications are provided. Specifically, the use of resonant resonant light scattering as an analytical method for determining either or both a particle's identity and the presence and optionally, the concentration of one or more particular target analytes is described. Applications of these microparticle-based methods in biological and chemical assays are also disclosed.

Microparticle-Based Methods And Systems And Applications Thereof
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US Patent:

20050282218, Dec 22, 2005
Filed:

Jul 25, 2005
Appl. No.:

11/188560
Inventors:

James Prober - Wilmington DE, US
Xiumin Cui - Swarthmore PA, US
Rudy Dam - Maple Valley WA, US
Edwin Hendrickson - Hockessin DE, US
Xueping Jiang - Wilmington DE, US
Michael Perry - Landenberg PA, US
Larry Steenhoek - Wilmington DE, US
International Classification:

C12Q001/68
G01N033/543
US Classification:

435006000, 436518000
Abstract:

Microparticle-based analytical methods, systems and applications are provided. Specifically, the use of resonant resonant light scattering as an analytical method for determining either or both a particle's identity and the presence and optionally, the concentration of one or more particular target analytes is described. Applications of these microparticle-based methods in biological and chemical assays are also disclosed.

Microparticle-Based Methods And Systems And Applications Thereof
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US Patent:

20050282219, Dec 22, 2005
Filed:

Jul 25, 2005
Appl. No.:

11/189062
Inventors:

James Prober - Wilmington DE, US
Xiumin Cui - Swarthmore PA, US
Rudy Dam - Maple Valley WA, US
Edwin Hendrickson - Hockessin DE, US
Xueping Jiang - Wilmington DE, US
Michael Perry - Landenberg PA, US
Larry Steenhoek - Wilmington DE, US
International Classification:

C12Q001/68
G01N033/543
US Classification:

435006000, 436518000
Abstract:

Microparticle-based analytical methods, systems and applications are provided. Specifically, the use of resonant resonant light scattering as an analytical method for determining either or both a particle's identity and the presence and optionally, the concentration of one or more particular target analytes is described. Applications of these microparticle-based methods in biological and chemical assays are also disclosed.

Microparticle-Based Methods And Systems And Applications Thereof
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US Patent:

20050282220, Dec 22, 2005
Filed:

Jul 25, 2005
Appl. No.:

11/189080
Inventors:

James Prober - Wilmington DE, US
Xiumin Cui - Swarthmore PA, US
Rudy Dam - Maple Valley WA, US
Edwin Hendrickson - Hockessin DE, US
Xueping Jiang - Wilmington DE, US
Michael Perry - Landenberg PA, US
Larry Steenhoek - Wilmington DE, US
International Classification:

C12Q001/68
G01N033/53
G01N033/537
G01N033/543
US Classification:

435006000, 435007920
Abstract:

Microparticle-based analytical methods, systems and applications are provided. Specifically, the use of resonant resonant light scattering as an analytical method for determining either or both a particle's identity and the presence and optionally, the concentration of one or more particular target analytes is described. Applications of these microparticle-based methods in biological and chemical assays are also disclosed.

Sol-Gel Coated Glass Microspheres For Use In Bioassay
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US Patent:

20070117089, May 24, 2007
Filed:

Nov 21, 2005
Appl. No.:

11/283664
Inventors:

Kevin Croker - Hockessin DE, US
Michael Damore - Wilmington DE, US
Kostantinos Kourtakis - Media PA, US
Michael Perry - Landenberg PA, US
James Prober - Wilmington DE, US
Paul Stull - Wilmington DE, US
International Classification:

C12Q 1/70
G01N 33/53
C12M 3/00
US Classification:

435005000, 435007100, 435287200, 977902000
Abstract:

A microsphere for use in a bioassay comprising a glass core coated with a sol-gel comprising a bioactive probe is provided. The sol-gel coating enhances the density of bioprobe loading on the surface of the microspheres, resulting in enhanced dynamic range and sensitivity in bioassays. The particle may be used in detection systems where resonant light scattering properties of the particle are useful.