James Phelan Sherbine

US Patent:

6392049, May 21, 2002

Filed:

May 18, 2001

Appl. No.:

09/861023

Inventors:

Larry K. Truesdale - San Diego CA
James P. Sherbine - Voorhees NJ
Benoit J. Vanasse - Collegeville PA

Assignee:

Aventis Pharmaceuticals Inc. - Bridgewater NJ

International Classification:

C07D21373

US Classification:

546296, 546297

Abstract:

The present invention is directed to a process for preparing 2,4-dihydroypyridine comprising heating a compound of the formula A wherein R is H, alkyl or aralkyl and phosphoric acid where the ratio of phosphoric acid to water is not less than about 27 to 1 weight %. The invention is also directed to a process for preparing 2,4-dihydroy-3-nitropyridine comprising reacting 2,4-dihydroypyridine with nitric acid. The processes of the present invention prepare intermediates which are useful in preparing compounds which are useful for treating cardiovascular disease marked by hypertension or myocardial ischeria, ameliorating ischemic injury or myocardial infarct size, or treating hyperlipidemia or hypercholesterolemia.

US Patent:

6753409, Jun 22, 2004

Filed:

Aug 15, 2000

Appl. No.:

09/639634

Inventors:

Zofia J. Chrzan - Sellersville PA
James J. Mencel - Lansdale PA
Vincent Windisch - Green Lane PA
Rick G. Woodward - Harleysville PA
Diane C. Salazar - late of Wayne PA
Narasimha M. Vemuri - Phoenixville PA
Anthony J. Gardetto - Oley PA
Matthew R. Powers - Barto PA
Gregory G. Kubiak - Wilmington DE
Robert C. Liu - Walnut Creek CA
Benoit J. Vanasse - Collegeville PA
James P. Sherbine - Voorhees NJ
Walter Rodriguez - Douglasville PA
Adam W. Sledeski - Collegeville PA

Assignee:

Aventis Pharmaceuticals Inc. - Bridgewater NJ

International Classification:

C07K 508

US Classification:

530331, 530333, 514 19

Abstract:

The invention is directed to a non-hygroscopic stable crystalline form of the antithrombotic compound N-[N-[N-(4-piperdin-4-yl)butanoyl)-N-ethylglycyl]-(L)-aspartyl]-(L)--cyclohexyl-alanine amide, to processes for preparing said stable crystalline form, to a pharmaceutical composition thereof, and intermediates thereof, and the invention is directed also to processes for preparing a compound of the formula wherein: A, B, Z, E , E , G, R, m, n, and p are as defined herein.

US Patent:

7208596, Apr 24, 2007

Filed:

Nov 10, 2004

Appl. No.:

10/985236

Inventors:

James P. Sherbine - Voorhees NJ, US
Shawn K. Pack - Plainsboro NJ, US
Jaan A. Pesti - Yardley PA, US
Robert E. Yule - Green Oaks IL, US
Kenneth C. McNulty - West Chester PA, US

Assignee:

Bristol-Myers Squibb Pharma Company - Princeton NJ

International Classification:

C07D 487/04
A61K 31/53
A61P 25/22
A61P 25/24
A61P 3/04
A61P 9/12

US Classification:

544180, 544217, 544220

Abstract:

The present invention provides novel processes and intermediates for preparing corticotropin releasing factor (CRF) receptor antagonists having the structure below which are useful in treating CRF-related disorders such as anxiety and depression.

US Patent:

7442792, Oct 28, 2008

Filed:

Mar 13, 2007

Appl. No.:

11/717440

Inventors:

James P. Sherbine - Voorhees NJ, US
Shawn K. Pack - Plainsboro NJ, US
Jaan A. Pesti - Yardley PA, US
Robert E. Yule - Green Oaks IL, US
Kenneth C. McNulty - West Chester PA, US

Assignee:

Bristol-Myers Squibb Pharma Company - Princeton NJ

International Classification:

C07D 487/04
A61K 31/53
A61P 3/04
A61P 9/12
A61P 25/22

US Classification:

544180, 544217, 544220

Abstract:

The present invention provides novel processes and intermediates for preparing corticotropin releasing factor (CRF) receptor antagonists having the structure below which are useful in treating CRF-related disorders such as anxiety and depression.

US Patent:

61843822, Feb 6, 2001

Filed:

Jan 12, 2000

Appl. No.:

9/481979

Inventors:

Diane C. Salazar - late of Wayne PA
Walter Rodriguez - Douglasville PA
James P. Sherbine - Voorhees NJ
Rick G. Woodward - Harleysville PA
Adam W. Sledeski - Collegeville PA
Matthew R. Powers - Barto PA
Michael K. O'Brien - Berwyn PA

Assignee:

Aventis Pharmaceuticals Products Inc. - Collegeville PA

International Classification:

C07D40912

US Classification:

5462814

Abstract:

The invention is directed to improved methods for preparing N6-substituted adenosine derivatives, to intermediates useful therefor and to methods of preparing these intermediates.

US Patent:

63070545, Oct 23, 2001

Filed:

Jul 1, 1998

Appl. No.:

9/108622

Inventors:

Larry K. Truesdale - San Diego CA
James P. Sherbine - Voorhees NJ
Benoit J. Vanasse - Collegeville PA

Assignee:

Aventis Pharmaceuticals Products Inc. - Bridgewater NJ

International Classification:

C07D21369
C07D21373
C07D21378

US Classification:

546296

Abstract:

The present invention is directed to a process for preparing 2,4-dihydroxy-pyridine comprising heating a compound of the formula A ##STR1## wherein R is H, alkyl or aralkyl and phosphoric acid where the ratio of phosphoric acid to water is not less than about 27 to 1 weight %. The invention is also directed to a process for preparing 2,4-dihydroxy-3-nitropyridine comprising reacting 2,4-dihydroxypyridine with nitric acid. The processes of the present invention prepare intermediates which are useful in preparing compounds which are useful for treating cardiovascular disease marked by hypertension or myocardial ischemia, ameliorating ischenic injury or myocardial infarct size, or treating hyperlipidemia or hypercholesterolemia.

US Patent:

61535885, Nov 28, 2000

Filed:

Feb 18, 1999

Appl. No.:

9/251030

Inventors:

Zofia J. Chrzan - Sellersville PA
James J. Mencel - Lansdale PA
Vincent Windisch - Green Lane PA
Rick G. Woodward - Harleysville PA
Diane C. Salazar - late of Wayne PA
Narasimha M. Vemuri - Phoenixville PA
Anthony J. Gardetto - Oley PA
Matthew R. Powers - Barto PA
Gregory G. Kubiak - Wilmington DE
Robert C. Liu - Walnut Creek CA
Benoit J. Vanasse - Collegeville PA
James P. Sherbine - Voorhees NJ
Walter Rodriguez - Douglasville PA
Adam W. Sledeski - Collegeville PA

Assignee:

Aventis Pharmaceuticals Products Inc. - Collegeville PA

International Classification:

A61K 3806
C07K 500

US Classification:

514 18

Abstract:

The invention is directed to a non-hygroscopic stable crystalline form of the antithrombotic compound N-[N-[N-(4-piperdin-4-yl)butanoyl)-N-ethylglycyl]-(L)-aspartyl]-(L)-. beta. -cyclohexyl-alanine amide, to processes for preparing said stable crystalline form, to a pharmaceutical composition thereof, and intermediates thereof, and the invention is directed also to processes for preparing a compound of the formula ##STR1## wherein: A, B, Z, E. sup. 1, E. sup. 2, G, R, m, n, and p are as defined herein.