Qiong J. Wang - Reston VA, US Kenichi Hanada - Bethesda MD, US James C. Yang - Silver Spring MD, US
Assignee:
The United States of America as represented by the Department of Health and Human Services - Washington DC
International Classification:
A61K 38/17
US Classification:
4241921, 530386
Abstract:
The invention provides an isolated or purified T cell receptor (TCR) having antigenic specificity for a cancer antigen, e. g. , a renal cell carcinoma antigen, wherein the TCR recognizes the cancer antigen in a major histocompatibility complex (MHC)-independent manner. Also provided are related polypeptides, proteins, nucleic acids, recombinant expression vectors, isolated host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions. The invention further provides a method of detecting the presence of cancer in a host and a method of treating or preventing cancer in a host using the inventive TCRs or related materials.
T Cell Receptors And Related Materials And Methods Of Use
Qiong J. Wang - Reston VA, US Kenichi Hanada - Bethesda MD, US James C. Yang - Silver Spring MD, US
Assignee:
The United States of America, as represented by the Secretary, Department of Health and Human Services - Washington DC
International Classification:
C07H 21/04
US Classification:
536 235, 4353201, 435325
Abstract:
The invention provides an isolated or purified T cell receptor (TCR) having antigenic specificity for a cancer antigen, e. g. , a renal cell carcinoma antigen, wherein the TCR recognizes the cancer antigen in a major histocompatibility complex (MHC)-independent manner. Also provided are related polypeptides, proteins, nucleic acids, recombinant expression vectors, isolated host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions. The invention further provides a method of detecting the presence of cancer in a host and a method of treating or preventing cancer in a host using the inventive TCRs or related materials.
Immunogenic Epitopes For Fibroblast Growth Factors 5 (Fgf-5)
Ken-Ichi Hanada - Rockville MD, US James Yang - Silver Spring MD, US
International Classification:
A61K 38/08 C07K 7/06
US Classification:
514017000, 530328000
Abstract:
The present disclosure relates to peptides for use in immunotherapy of FGF-5 expressing tumors. In one example, the peptide is an HLA-A3 epitope (such as NTYASPRFK). In another example, the peptide is an HLA-A2 epitope (such as MLSVLEIFAV). Methods are provided for using such peptides (and corresponding nucleic acid molecules), and variants, fragments or fusions thereof, to stimulate an immune response in a subject. The peptides (and corresponding nucleic acid molecules) disclosed herein can be formulated into pharmaceutical composition for administration to a subject.
T Cell Receptors And Related Materials And Methods Of Use
The United States of America, as represented by the Secretary, Department of Health and Human Services - Bethesda MD, US Kenichi Hanada - Bethesda MD, US James C. Yang - Silver Spring MD, US
Assignee:
The U.S.A , as represented by the Secretary, Department of Health and Human Services - Bethesda MD
The invention provides an isolated or purified T cell receptor (TCR) having antigenic specificity for a cancer antigen, e.g., a renal cell carcinoma antigen, wherein the TCR recognizes the cancer antigen in a major histocompatibility complex (MHC)-independent manner. Also provided are related polypeptides, proteins, nucleic acids, recombinant expression vectors, isolated host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions. The invention further provides a method of detecting the presence of cancer in a host and a method of treating or preventing cancer in a host using the inventive TCRs or related materials.
- Bethesda MD, US Chihao Zhao - Bethesda MD, US Anna Pasetto - Stockholm, SE James C. Yang - Bethesda MD, US
Assignee:
The United States of America,as represented by the Secretary,Department of Health and Human Services - Bethesda MD
International Classification:
C07K 14/725 G01N 33/574 A61K 35/17
Abstract:
Disclosed is an isolated or purified T cell receptor (TCR), wherein the TCR has antigenic specificity for a mutated EGFR amino acid sequence with a E746-A750 deletion. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.
The invention provides a chimeric antigen receptor (CAR) having antigenic specificity for CD70, the CAR comprising: an antigen binding—transmembrane domain comprising a CD27 amino acid sequence lacking all or a portion of the CD27 intracellular T cell signaling domain; a 4-1BB intracellular T cell signaling domain; a CD3ζ intracellular T cell signaling domain; and optionally, a CD28 intracellular T cell signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal are also disclosed.
- Bethesda MD, US Qiong J. Wang - Potomac MD, US James C. Yang - Bethesda MD, US Zhiya Yu - Potomac MD, US
Assignee:
The United States of America,as represented by the Secretary,Department of Health and Human Services - Bethesda MD
International Classification:
C07K 16/26 C07K 14/725 A61P 35/04 A61P 35/00
Abstract:
Disclosed is a synthetic T cell receptor (TCR) having antigenic specificity for an HLA-A2-restricted epitope of thyroglobulin (TG), TG. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, and populations of cells are also provided. Antibodies, or an antigen binding portion thereof, and pharmaceutical compositions relating to the TCRs of the invention are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.
- Bethesda MD, US Qiong J. Wang - Potomac MD, US James C. Yang - Bethesda MD, US Zhiya Yu - Potomac MD, US
Assignee:
The United States of America, as represented by the Secretary, Department of Health and Human - Bethesda MD
International Classification:
C07K 16/26 C07K 14/725 A61P 35/00 A61P 35/04
Abstract:
Disclosed is a synthetic T cell receptor (TCR) having antigenic specificity for an HLA-A2-restricted epitope of thyroglobulin (TG), TG. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, and populations of cells are also provided. Antibodies, or an antigen binding portion thereof, and pharmaceutical compositions relating to the TCRs of the disclosure are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.
Feb 2011 to 2000 Corporate Sales Director (A member of Korea Management Committee)Berlitz Corporation
Feb 2011 to Aug 2011 Sales Director TrainingSunrider International
Sep 2007 to Feb 2011 Sales Manager Strategic Meeting &TrainingCopyQ24 of Modenoffice
Oct 2009 to Jan 2011 Senior Sales & Operation ManagerSunrider Korea
Jun 2007 to Jun 2008 Sales ManagerFranklin Covey Licensee
Aug 2005 to Apr 2007 R&D DirectorAU Harrison Assessment, Korea
Oct 2006 to Jan 2007 Expert levelIBO
2007 to 2007 Leader MeetingsFedExkinko's Korea
Jan 2003 to Mar 2005 Sales ManagerFranklinCovey Japan
Jun 2003 to Feb 2004UPS APAC Region Singapore Aug 2002 to May 2003 UPS Air Dangerous Goods Acceptance AuditorUPS-Korea Express
Aug 2001 to Dec 2002 Area Sales Manager & Korea BD TrainerUPS APAC Region Singapore May 2002 to Aug 2002 UPS BD TrainerFedEx Korea
Nov 1994 to Oct 2000 District Sales ManagerYBM Si-sa
Oct 1991 to Jul 1994 Secretary to CEODep't of English Language and Literature in Inha Univ
Aug 1985 to Feb 1986 Class ChiefDep't of English Language and Literature in Inha Univ
Aug 2011 to Present Leadership & Sales Trainings
Education:
Helsinki School of Economics and Business Administration /Finland Sep 2008 to Mar 2010 Global ManagementInha University / Korea Mar 1985 to Feb 1992 BA in English Language and Literature
Jun 2013 to Jul 2013 Assistant Resort ManagerIndia Grill Rockville, MD Jun 2012 to Aug 2012 Server/HostChinese Christian Church of Greater Washington, DC Jun 2011 to 2012 Intern
Education:
New York University in Florence Firenze, Toscana Mar 2014 ItalianThomas S. Wootton High School Rockville, MD May 2012 Humanities & Arts ProgramNew York University New York, NY Bachelor of Arts in Philosophy
Feb 2011 to 2000 Corporate Sales Director (A member of Korea Management Committee)Berlitz Corporation
Feb 2011 to Feb 2011 Sales Director TrainingSunrider International
Sep 2007 to Feb 2011 Sales Manager Strategic Meeting &TrainingCopyQ24 of Modenoffice
Oct 2009 to Jan 2011 Senior Sales & Operation ManagerSunrider Korea
Jul 2007 to Jun 2008 Sales ManagerCreative & Rational Decision Singapore May 2006 to May 2007 R&D DirectorFranklin Covey Licensee
Aug 2005 to Apr 2007 R&D DirectorAU Harrison Assessment, Korea
Oct 2006 to Jan 2007 Expert levelIBO
2007 to 2007 Leader MeetingsFranklinCovey Licensee
Sep 2006 to Oct 2006AU Harrison Assessment, Korea
Aug 2006 to Sep 2006Kyungkkido Police
Jul 2005 to Aug 2006FranklinCovey Licensee
May 2006 to May 2006FranklinCovey Licensee
Dec 2005 to May 2006FranklinCovey Licensee
Sep 2005 to Dec 2005Richardson Co
Feb 2004 to Sep 2005APAC Region Singapore May 2002 to Jul 2005FedExkinko's Korea
Jan 2003 to Mar 2005 Sales ManagerFranklinCovey Japan
Jun 2003 to Feb 2004KMAC Korea
May 2003 to Jun 2003UPS APAC Region Singapore Aug 2002 to May 2003 UPS Air Dangerous Goods Acceptance AuditorUPS-Korea Express
Aug 2001 to Dec 2002 Area Sales Manager & Korea BD TrainerUPS APAC Region Singapore May 2002 to Aug 2002 UPS BD TrainerPri-Ex Inc
Dec 1997 to May 2002FedEx Korea
Nov 1994 to Oct 2000 District Sales ManagerKyungkkido Police
Aug 1985 to 1997YBM Si-sa
Oct 1991 to Jul 1994 Secretary to CEOKorea Army Service
Jan 1987 to Apr 1989Dep't of English Language and Literature in Inha Univ
Aug 1985 to Feb 1986 Class ChiefDep't of English Language and Literature in Inha Univ
Aug 2011 to Present Leadership & Sales TrainingsFranklinCovey USA
Jan 2007 to Present
Education:
Helsinki School of Economics and Business Administration /Finland Sep 2008 to Mar 2010 MBA in Global ManagementInha University / Korea Mar 1985 to Feb 1992 BA in English Language and Literature
Medicine Doctors
Dr. James C Yang, Bethesda MD - MD (Doctor of Medicine)
Medical School University of California At San Diego Graduated: 1978 Medical School U Calif Hosps Graduated: 1978 Medical School Natl Canc Inst Graduated: 1978
Dr. James C Yang, Washington DC - MD (Doctor of Medicine)
Public Health & General Preventive Medicine, Internal Medicine
Work:
Virginia Center For Health & Wellness 39070 John Mosby Hwy, Aldie, VA 20105 (703)3272434 (phone), (703)3272729 (fax)
George Washington Medical Faculty AssociatesMetro IPC Capitol Hill 220 L St NE FL 1, Washington, DC 20002 (202)5447580 (phone), (202)8277867 (fax)
Education:
Medical School Emory University School of Medicine Graduated: 2008
Conditions:
Abnormal Vaginal Bleeding Acute Bronchitis Acute Sinusitis Acute Upper Respiratory Tract Infections Candidiasis of Vulva and Vagina
Languages:
English
Description:
Dr. Yang graduated from the Emory University School of Medicine in 2008. He works in Aldie, VA and 1 other location and specializes in Public Health & General Preventive Medicine and Internal Medicine.
James T Yang MD 16300 Sand Cyn Ave STE 807, Irvine, CA 92618 (949)7537999 (phone), (949)7531649 (fax)
Education:
Medical School Natl Taiwan Univ Coll of Med, Taipei, Taiwan (385 02 Prior 1/71) Graduated: 1972
Conditions:
Abnormal Vaginal Bleeding Breast Disorders Candidiasis of Vulva and Vagina Complicating Pregnancy or Childbirth Conditions of Pregnancy and Delivery
Languages:
Chinese English Vietnamese
Description:
Dr. Yang graduated from the Natl Taiwan Univ Coll of Med, Taipei, Taiwan (385 02 Prior 1/71) in 1972. He works in Irvine, CA and specializes in Obstetrics & Gynecology. Dr. Yang is affiliated with Fountain Valley Regional Hospital & Medical Center and Hoag Memorial Hospital Presbyterian.
Columbus Elementary School Appleton WI 1988-1994, Roosevelt Middle School Appleton WI 1994-1994, Sun Prairie Junior High School Sun Prairie WI 1994-1996
one example now of several examples where people can now use immune cells recognizing cancer to reject, and in some cases it's been well shown for 10 years now, that they can cure certain types of cancer with this approach," says Dr. James Yang, a senior investigator at the National Cancer Institute.
Stetina Brunda Garred & Brucker I am a patent attorney for Stetina Brunda Garred & Brucker. I advise clients of all sizes in protecting their intellectual property and avoiding infringement... I am a patent attorney for Stetina Brunda Garred & Brucker. I advise clients of all sizes in protecting their intellectual property and avoiding infringement of patent rights of others.
Virginia Commonwealth University - BFA Communication Arts & Design
About:
I am a Korean illustrator who grew up in Oklahoma, found my way to New York City, married a Hong Kong girl who is an acclaimed choreographer/dancer and ended up in Brooklyn. It is a very typical story...
Tagline:
Brooklyn Based Illustrator
Bragging Rights:
As a 10 year old running back for my grade school football team I once ran 50 yards while my pants were falling down. This is still the most impressive thing I have done to this day.
James Yang
Lived:
Fairfax, VA
Education:
George Mason University - Information Technology, Chantilly High School