Jan L Sechler from 5678 Deer Run Rd, Gardenville, PA 18901, age 58, Phone: (215)7947527

Acylhydrazones As Kinase Modulators
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US Patent:

7662824, Feb 16, 2010
Filed:

Mar 16, 2006
Appl. No.:

11/377077
Inventors:

Kristi Leonard - West Chester PA, US
Tianbao Lu - Churchville PA, US
Robert W. Tuman - Chalfont PA, US
Dana L. Johnson - Upper Black Eddy PA, US
Anna C. Maroney - Media PA, US
Jan L. Sechler - Doylestown PA, US
Richard W. Connors - Harleysville PA, US
Richard S. Alexander - Newark DE, US
Maxwell D. Cummings - Wayne PA, US
Robert A. Galemmo - Paoli PA, US
Thomas P. Markotan - Morgantown PA, US
Assignee:

Janssen Pharmaceutica NV - Beerse
International Classification:

A61K 31/496
A61K 31/404
C07D 405/14
C07D 405/12
C07D 407/14
US Classification:

51425409, 514414, 514418, 514422, 514323, 514469, 514416, 544373, 544144, 546201, 548454, 548483, 548518, 548525, 548490, 549462
Abstract:

The invention is directed to acylhydrazones compounds of Formula I:.

N-Substituted Tricyclic 1-Aminopyrazoles As Inhibitors For The Treatment Of Cell Proliferative Disorders
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US Patent:

7795440, Sep 14, 2010
Filed:

Jan 25, 2007
Appl. No.:

11/657912
Inventors:

Chih Yung Ho - Lansdale PA, US
Bengt Anders Brunmark - LaJolla CA, US
Stuart Emanuel - Doylestown PA, US
Dana L. Johnson - Upper Black Eddy PA, US
Donald W. Ludovici - Quakertown PA, US
Umar Maharoof - North Wales PA, US
Jay M. Mei - North Wales PA, US
Jan L. Sechler - Doylestown PA, US
Eric D. Strobel - Hatboro PA, US
Robert W. Tuman - Chalfont PA, US
Hwa Kwo Yen - Malvern PA, US
Assignee:

Janssen Pharmaceutica NV
International Classification:

A61K 31/416
A61K 31/4439
C07D 401/12
US Classification:

5462757, 5483595, 514338, 514405
Abstract:

The invention is directed to N-substituted tricyclic 3-AMINOPYRAZOLE derivatives, which are useful as inhibitors of platelet-derived growth factor receptor (PDGF-R) kinase, and methods for the preparation of said derivatives. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as tumors and other cell proliferative disorders.

Triazolopyridazines As Kinase Modulators
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US Patent:

8030305, Oct 4, 2011
Filed:

Dec 18, 2006
Appl. No.:

11/612020
Inventors:

Tianbao Lu - Churchville PA, US
Richard Alexander - Newark DE, US
Richard W. Connors - Harleysville PA, US
Maxwell D. Cummings - Wayne PA, US
Robert A. Galemmo - Paoli PA, US
Heather Rae Hufnagel - Glenmoore PA, US
Dana L. Johnson - Upper Black Eddy PA, US
Ehab Khalil - West Chester PA, US
Kristi A. Leonard - Flourtown PA, US
Thomas P. Markotan - Morgantown PA, US
Anna C. Maroney - Media PA, US
Jan L. Sechler - Doylestown PA, US
Jeremy M. Travins - Downingtown PA, US
Robert W. Tuman - Chalfont PA, US
Assignee:

Janssen Pharmaceutica N.V.
International Classification:

C07D 487/04
A61K 31/5025
A61P 35/00
US Classification:

514248, 544236
Abstract:

The invention is directed to triazolopyridazine compounds of Formula I:.

Triazolopyridazine Compounds
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US Patent:

8173654, May 8, 2012
Filed:

Aug 7, 2008
Appl. No.:

12/187524
Inventors:

Tianbao Lu - Churchville PA, US
Richard Alexander - Newark DE, US
Richard W. Connors - Harleysville PA, US
Maxwell D. Cummings - Wayne PA, US
Robert A. Galemmo - Paoli PA, US
Heather Rae Hufnagel - Glenmoore PA, US
Dana L. Johnson - Upper Black Eddy PA, US
Ehab Khalil - West Chester PA, US
Kristi A. Leonard - Flourtown PA, US
Thomas P. Markotan - Morgantown PA, US
Anna C. Maroney - Media PA, US
Jan L. Sechler - Doylestown PA, US
Jeremy M. Travins - Downingtown PA, US
Robert W. Tuman - Chalfont PA, US
Assignee:

Janssen Pharmaceutica N.V. - Beerse
International Classification:

A61K 31/4985
C07D 487/04
A61P 3/10
A61P 17/06
A61P 25/18
A61P 19/02
A61P 9/10
A61P 9/00
A61P 35/00
US Classification:

514248, 544236
Abstract:

The invention is directed to triazolopyridazine compounds of Formula I:.

N-Substituted Tricyclic 3-Aminopyrazoles As Inhibitors For The Treatment Of Cell Proliferative Disorders
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US Patent:

20040082639, Apr 29, 2004
Filed:

May 14, 2003
Appl. No.:

10/438152
Inventors:

Chih Ho - Lansdale PA, US
Bengt Brunmark - LaJolla CA, US
Stuart Emanuel - Doylestown PA, US
Robert Galemmo - Collegeville PA, US
Dana Johnson - Upper Black Eddy PA, US
Donald Ludovici - Quakertown PA, US
Umar Maharoof - North Wales PA, US
Jay Mei - North Wales PA, US
Jan Sechler - Doylestown PA, US
Eric Strobel - Hatboro PA, US
Robert Tuman - Chalfont PA, US
Hwa Yen - Malvern PA, US
International Classification:

A61K031/415
C07D231/56
C07D231/54
US Classification:

514/405000, 548/359100, 548/360100
Abstract:

The invention is directed to N-substituted tricyclic 3-AMINOPYRAZOLE derivatives, which are useful as inhibitors of platelet-derived growth factor receptor (PDGF-R) kinase, and methods for the preparation of said derivatives. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as tumors and other cell proliferative disorders.