Jane A Connor

US Patent:

20030013702, Jan 16, 2003

Filed:

Sep 24, 2001

Appl. No.:

09/961969

Inventors:

Pamela Manning - Labadie MO, US
Jane Connor - University City MO, US
Karen Seibert - St. Louis MO, US
Bandaru Reddy - Suffern NY, US

International Classification:

A61K031/66
A61K031/55
A61K031/198
A61K031/415

US Classification:

514/217110, 514/406000, 514/471000, 514/565000, 514/114000, 514/551000, 514/626000

Abstract:

Agents and methods for chemoprevention and treatment of neoplasia are described, the agents including a selective inhibitor of inducible nitric oxide synthase and a combination of a selective inhibitor of inducible nitric oxide synthase and an inhibitor of cylcooxygenase-2 in a pharmaceutical composition. The agents and methods are used for chemoprevention and treatment of neoplasia including colorectal cancer and other cancers affecting epithelial cells throughout the body. The agents can also be used to treat the fibrosis that occurs with radiation therapy, as well as adenomatous polyps, including those with familial adenomatous polyposis (FAP).

US Patent:

20030109522, Jun 12, 2003

Filed:

Sep 24, 2001

Appl. No.:

09/961816

Inventors:

Pamela Manning - Labadie MO, US
Jane Connor - University City MO, US

International Classification:

A61K031/54
A61K031/537
A61K031/495
A61K031/445
A61K031/40
A61K031/198
A61K031/221
A61K031/16

US Classification:

514/227500, 514/237500, 514/255010, 514/330000, 514/423000, 514/550000, 514/564000, 514/626000

Abstract:

Therapeutic methods for the prevention and treatment of ophthalmologic conditions are described, the methods including administering to a subject in need thereof a selective inhibitor of inducible nitric oxide synthase.

US Patent:

20030119826, Jun 26, 2003

Filed:

Sep 24, 2001

Appl. No.:

09/961521

Inventors:

Pamela Manning - Labadie MO, US
Jane Connor - University City MO, US

Assignee:

Pharmacia Corporation

International Classification:

A61K031/54
A61K031/537
A61K031/495
A61K031/198
A61K031/221
A61K031/16

US Classification:

514/227500, 514/255010, 514/237500, 514/551000, 514/423000, 514/565000, 514/330000, 514/626000

Abstract:

Therapeutic methods for the prevention and treatment of neurodegenerative conditions are described, the methods including administering to a subject in need thereof a neuroprotective effective amount of a selective inhibitor of inducible nitric oxide synthase.

US Patent:

20050113409, May 26, 2005

Filed:

Sep 2, 2004

Appl. No.:

10/932385

Inventors:

Jane Connor - University City MO, US
Pamela Manning - Chesterfield MO, US

Assignee:

Pharmacia Corporation - Chesterfield MO

International Classification:

A61K031/47
A61K031/382
A61K031/353
A61K031/277
A61K031/18

US Classification:

514311000, 514432000, 514456000, 514602000, 514520000

Abstract:

A method is described for the prevention or treatment of pain, inflammation, and inflammation-related disorders in a subject in need of such prevention or treatment, the method comprising administering to the subject a cyclooxygenase-2 selective inhibitor in combination with a nitric oxide-donating agent. Also described are therapeutic and pharmaceutical compositions and kits that are useful in the present invention.