Jane H Connor

US Patent:

20180215818, Aug 2, 2018

Filed:

Nov 22, 2017

Appl. No.:

15/820943

Inventors:

- Gaithersburg MD, US
- Helsinki, FI
Karl Lemstrom - Helsinki, FI
Ching Ching Leow - Gaithersburg MD, US
Ronald Herbst - Gaithersburg MD, US
Jane Connor - Gaithersburg MD, US

International Classification:

C07K 16/22
A61K 39/395

Abstract:

The disclosure is directed to methods and uses of antibodies or antigen-binding fragments thereof against Angiopoietin-2 (Ang-2). Specifically, the disclosure is direct to the use of anti-Ang2 antibodies or antigen-binding fragments thereof for treating ischemia. The methods disclosed are useful for reducing microvascular permeability, increasing microvascular perfusion, reducing inflammation in a tissue, and treating or ameliorating diseases associated with ischemia and/or reperfusion injury. The disclosed methods are also useful for protecting solid organ transplant tissue and treating or preventing chronic tissue transplant rejection.

US Patent:

20160222099, Aug 4, 2016

Filed:

Jan 29, 2016

Appl. No.:

15/010253

Inventors:

- Gaithersburg MD, US
- Helsinki, FI
KARL LEMSTROM - HELSINKI, FI
CHING CHING LEOW - GAITHERSBURG MD, US
RONALD HERBST - GAITHERSBURG MD, US
JANE CONNOR - GAITHERSBURG MD, US

International Classification:

C07K 16/22

Abstract:

The disclosure is directed to methods and uses of antibodies or antigen-binding fragments thereof against Angiopoietin-2 (Ang-2). Specifically, the disclosure is direct to the use of anti-Ang2 antibodies or antigen-binding fragments thereof for treating ischemia. The methods disclosed are useful for reducing microvascular permeability, increasing microvascular perfusion, reducing inflammation in a tissue, and treating or ameliorating diseases associated with ischemia and/or reperfusion injury. The disclosed methods are also useful for protecting solid organ transplant tissue and treating or preventing chronic tissue transplant rejection.

US Patent:

20150044227, Feb 12, 2015

Filed:

Mar 7, 2013

Appl. No.:

14/383377

Inventors:

Kari ALITALO - Helsinki, FI
Simo SYRJALA - Helsinki, FI
Karl M. LEMSTROM - Helsinki, FI
- Gaithersburg MD, US
Ronald Herbst - Gaithersburg MD, US
Jane Connor - Gaithersburg MD, US

International Classification:

A61K 39/395

US Classification:

4241581

Abstract:

The disclosure is directed to methods and uses of antibodies or antigen-binding fragments thereof against Angiopoietin-2 (Ang-2). Specifically, the disclosure is direct to the use of anti-Ang2 antibodies or antigen-binding fragments thereof for treating ischemia. The methods disclosed are useful for reducing microvascular permeability, increasing microvascular perfusion, reducing inflammation in a tissue, and treating or ameliorating diseases associated with ischemia and/or reperfusion injury. The disclosed methods are also useful for protecting solid organ transplant tissue and treating or preventing chronic tissue transplant rejection.