Jane W Richards

US Patent:

6670323, Dec 30, 2003

Filed:

Nov 10, 2000

Appl. No.:

09/709914

Inventors:

Douglas L. Looker - Lafayette CO
Izydor Z. Apostol - Boulder CO
Eric A. Brucker - Evergreen CO
Michael P. Doyle - Boulder CO
David L. Foster - Lafayette CO
Christopher B. Glascock - Louisville CO
James C. Hartman - Boulder CO
Geoffrey F. Lee - Boulder CO
Douglas D. Lemon - Louisville CO
Edwin G. Moore - Boulder CO
Jane P. Richards - Longmont CO
Michael R. Schick - Louisville CO
Stephen P. Trimble - Boulder CO
David Pereira - Apex NC
Ton-That Hai - Mundelein IL
Kenneth E. Burhop - Longmont CO

Assignee:

Baxter International, Inc. - Deerfield IL
Baxter Healthcare S.A. - Kanton Zurich

International Classification:

C07K 14805

US Classification:

514 6, 535385

Abstract:

The invention relates to novel hemoglobin compositions, particularly novel recombinant mutant hemoglobin compositions, which eliminate or substantially reduce 1) the creation of heart lesions, 2) gastrointestinal discomfort, 3) pressor effects, and 4) endotoxin hypersensitivity associated with the administration of extracellular hemoglobin compositions in various therapeutic applications. Applications described include treatments for anemia, head injury, hemorrhage or hypovolemia, ischemia, cachexia, sickle cell crisis and stroke; enhancing cancer treatments; stimulating hematopoiesis; improving repair of physically damaged tissues; alleviating cardiogenic shock; and shock resuscitation.

US Patent:

7211560, May 1, 2007

Filed:

Dec 29, 2003

Appl. No.:

10/747580

Inventors:

Douglas L. Looker - Fort Lupton CO, US
Izydor Z. Apostol - Boulder CO, US
Eric A. Brucker - Evergreen CO, US
Michael P. Doyle - Boulder CO, US
David L. Foster - Lafayette CO, US
Christopher B. Glascock - Louisville CO, US
James C. Hartman - Boulder CO, US
Geoffrey F. Lee - Boulder CO, US
Douglas D. Lemon - Louisville CO, US
Edwin G. Moore - Boulder CO, US
Jane P. Richards - Longmont CO, US
Michael R. Schick - Louisville CO, US
Stephen P. Trimble - Boulder CO, US
David Pereira - Apex NC, US
Ton-That Hai - Mundelein IL, US
Kenneth E. Burhop - Longmont CO, US

Assignee:

Baxter International, Inc. - Deerfield IL
Baxter Healthcare S.A. - Zurich

International Classification:

A61K 35/14

US Classification:

514 6, 530385

Abstract:

The invention relates to novel hemoglobin compositions, particularly novel recombinant mutant hemoglobin compositions, which eliminate or substantially reduce 1) the creation of heart lesions, 2) gastrointestinal discomfort, 3) pressor effects, and 4) endotoxin hypersensitivity associated with the administration of extracellular hemoglobin compositions in various therapeutic applications. Applications described include treatments for anemia, head injury, hemorrhage or hypovolemia, ischemia, cachexia, sickle cell crisis and stroke; enhancing cancer treatments; stimulating hematopoiesis; improving repair of physically damaged tissues; alleviating cardiogenic shock; and shock resuscitation.