Janice M Allen

US Patent:

55917194, Jan 7, 1997

Filed:

Dec 10, 1992

Appl. No.:

7/990296

Inventors:

Leo T. Furcht - Minneapolis MN
James B. McCarthy - Minneapolis MN
Sharon M. Wahl - Gaithersburg MD
Janice B. Allen - Wheaton MD

Assignee:

Regents of the University of Minnesota - Minneapolis MN
The United States of America as represented by the Secretary of Health
and Human Services - Washington DC

International Classification:

A61K 3800
C07K 706
C07K 710

US Classification:

514 13

Abstract:

A method for treating acute or chronic inflammatory or autoimmune disorders using polypeptides with fibronectin or related activity is provided. The method involves (administering an amount of) one or more polypeptides corresponding to isolated amino acid residue sequences of the 33 kD carboxy terminal heparin-binding region located on the A chain of fibronectin to effectively suppress inflammation and impairment of tissue function in a patient.

US Patent:

58406913, Nov 24, 1998

Filed:

Jun 7, 1995

Appl. No.:

8/480133

Inventors:

Leo T. Furcht - Minneapolis MN
James B. McCarthy - Minneapolis MN
Sharon M. Wahl - Gaithersburg MD
Janice B. Allen - Wendell NC
Kevin L. Billups - Savage MN
Jeffrey E. Everett - Arden Hills MN

International Classification:

A61K 3804
A61K 3808
A61K 3810
A61K 3816

US Classification:

814 12

Abstract:

Methods for treating ischemia using polypeptides with fibronectin related activity are provided. The methods involve administering an effective amount of one or more polypeptides which include an amino acid sequence corresponding substantially to isolated an amino acid sequence from the 33 kD carboxy terminal heparin-binding region located on the A chain of fibronectin or an RGD-containing amino acid sequence within the 11. 5 kD RGDS-mediated cell adhesion region located on all isoforms of fibronectin.