- Rahway NJ, US Jared Lunceford - Washington UT, US Andrey Loboda - Boston MA, US Terrill K. McClanahan - Sunnyvale CA, US Heather Hirsch - Brookline MA, US
The present disclosure describes baseline and on treatment blood-based gene signature biomarkers that are predictive of tumor sensitivity to therapy with a PD-1 antagonist. The on-treatment biomarkers comprise a PD-L1 gene signature or an interferon gamma gene signature and the baseline gene signature biomarker comprises genes associated with the oxidative phosphorylation pathway. The disclosure also provides methods and kits for testing tumor samples for these biomarkers, as well as methods for treating subjects with a PD-1 antagonist based on the test results.
Gene Signature Biomarkers Of Tumor Response To Pd-1 Antagonists
- Rahway NJ, US Andrey Loboda - Canton MA, US Jared Lunceford - Washington UT, US Terrill K. McClanahan - Sunnyvale CA, US Erin Murphy - Redwood City CA, US Robert H. Pierce - San Francisco CA, US
Assignee:
Merck Sharp & Dohme Corp. - Rahway NJ
International Classification:
C12Q 1/68 C07K 16/28 G06F 19/20
Abstract:
The present disclosure describes gene signature biomarkers that are useful for identifying cancer patients who are most likely to benefit from treatment with a PD-1 antagonist. The disclosure also provides methods and kits for testing tumor samples for the biomarkers, as well as methods for treating subjects with a PD-1 antagonist based on the test results.
Pd-L1 Gene Signature Biomarkers Of Tumor Response To Pd-1 Antagonists
- Rahway NJ, US Andrey Loboda - Canton MA, US Jared Lunceford - Washington UT, US Terrill K. McClanahan - Sunnyvale CA, US Erin Murphy - Redwood City CA, US Robert H. Pierce - San Francisco CA, US
Assignee:
Merck Sharp & Dohme Corp. - Rahway NJ
International Classification:
C12Q 1/68 C07K 16/28
Abstract:
The present disclosure describes PD-L1 gene signature biomarkers that are useful for identifying cancer patients who are most likely to benefit from treatment with a PD-1 antagonist. The disclosure also provides methods and kits for testing tumor samples for the biomarkers, as well as methods for treating subjects with a PD-1 antagonist based on the test results.
Ifn-Gamma Gene Signature Biomarkers Of Tumor Response To Pd-1 Antagonists
- Rahway NJ, US Andrey Loboda - Canton MA, US Jared Lunceford - Washington UT, US Terrill K. McClanahan - Sunnyvale CA, US Erin Murphy - Redwood City CA, US Robert H. Pierce - San Francisco CA, US
Assignee:
Merck Sharp & Dohme Corp. - Rahway NJ
International Classification:
C12Q 1/68 C07K 16/28 G06F 19/20
Abstract:
The present disclosure describes IFN-γ gene signature biomarkers that are useful for identifying cancer patients who are most likely to benefit from treatment with a PD-1 antagonist. The disclosure also provides methods and kits for testing tumor samples for the biomarkers, as well as methods for treating subjects with a PD-1 antagonist based on the test results.
Myriad Genetics 2007 - 2007
Associate Director of Biostatistics
Merck 2007 - 2007
Distinguished Scientist
Education:
North Carolina State University 1996 - 2001
Doctorates, Doctor of Philosophy, Statistics
Brigham Young University 1994 - 1996
Master of Science, Masters, Molecular Biology
Brigham Young University 1991 - 1994
Bachelors, Bachelor of Science, Molecular Biology
Skills:
Clinical Development Pharmaceutical Industry Oncology Biostatistics Therapeutic Areas Translational Medicine Fda Validation Genomics Biomarker Discovery Statistics