Jared Miller Wagner

US Patent:

6337351, Jan 8, 2002

Filed:

Sep 8, 1999

Appl. No.:

09/391747

Inventors:

Gary Maurice Dull - Lewisville NC
Jared Miller Wagner - Stillwater OK
William Scott Caldwell - Winston-Salem NC
Craig Harrison Miller - Winston-Salem NC
Jeffrey Daniel Schmitt - Winston-Salem NC
Balwinder Singh Bhatti - Winston-Salem NC
Srishailkumar Basawannappa Hadimani - Winston-Salem NC

Assignee:

Targacept, Inc. - Winston-Salem NC

International Classification:

A01N 3302

US Classification:

514649, 514654, 564336, 564374, 564383

Abstract:

Pharmaceutical compositions aryl substituted amine compounds, and in particular, 3-aminophenyl amine compounds are provided. Representative compounds are (4E)-N-methyl-5-(3-acetamido-4-methylphenyl)-4-penten-2-amine, (4E)-N-methyl-5-(3-amino-4-methylphenyl)-4-penten-2-amine, (4E)-N-methyl-5-(3-(dimethylamino)phenyl)-4-penten-2-amine, (4E)-N-methyl-5-(4-methyl-3-nitrophenyl)-4-penten-2-amine, (4E)-N-methyl-5-(3-fluorophenyl)-4-penten-2-amine, (4E)-N-methyl-5-(3,4-dichlorophenyl)-4-penten-2-amine and (4E)-N-methyl-5-(3,4-methylenedioxyphenyl)-4-penten-2-amine.

US Patent:

6441006, Aug 27, 2002

Filed:

May 24, 1999

Appl. No.:

09/317321

Inventors:

Gary Maurice Dull - Lewisville NC
Jared Miller Wagner - Stillwater OK
Srishailkumar B. Hadimani - Winston-Salem NC
Michael B. Consilvio - Potomac MD

Assignee:

Targacept, Inc. - Winston-Salem NC

International Classification:

A61K 3144

US Classification:

514351, 546300

Abstract:

Patients susceptible to or suffering from conditions and disorders, such as central nervous system disorders, are treated by administering to a patient in need thereof aryloxyalkylamines, including pyridyloxylalkylamines and phenoxyalkylamines. Exemplary compounds include dimethyl(2-(3-pyridyloxy)ethylamine, dimethyl(4-(3-pyridyloxy)butyl)amine, 2-(3-pyridyloxy)ethylamine, 4-(3-pyridyloxy)butylamine, methyl(3-(5-methoxy-3-pyridyloxy)propyl)amine, ethyl(3-(3-pyridyloxy)propyl)amine, methyl(2-(3-pyridyloxy)ethyl)amine, methyl(3-(6-methyl(3-pyridyloxy))propyl)amine, (3-(3-methoxyphenoxy)propyl)methylamine, (3-(5-chloro(3-pyridyloxy))-1-methylpropyl)methylamine, dimethyl(3-(3-pyridyloxy)propyl)amine, 3-(3-pyridyloxy)propylamine, methyl(4-(3-pyridyloxy)butyl)amine, 3-(5-chloro-3-pyridyloxy)propylamine, methyl(3-(5-isopropoxy-3-pyridyloxy)propyl)amine, (3-(5-chloro(3-pyridyloxy))propyl)methylamine, methyl(3-(5-(phenylmethoxy)(3-pyridyloxy))propyl)amine, methyl(3-(2-methyl(3-pyridyloxy))propyl)amine, (methylethyl)(3-(3-pyridyloxy)propyl)amine, benzyl(3-(3-pyridyloxy)propyl)amine, cyclopropyl(3-(3-pyridyloxy)-propyl)amine, methyl(1-methyl-3-(3-pyridyloxy)propyl)amine, methyl(3-(3-nitrophenoxy)propyl)amine, 1-(3-chloropropoxy)-3-nitrobenzene, (3-(3-aminophenoxy)propyl)methylamine, dimethyl(3-(3-(methylamino)-propoxy)phenyl)amine, methyl(3-tricyclo[7. 3. 1. 05,13 ]tridec-2-yloxypropyl)amine, (3-benzo[3,4-d]1,3-dioxolan-5-yloxypropyl)methylamine, 3-(4-piperidinyloxy)pyridine and 3-((3S)-3-pyrrolidinyloxy)pyridine.

US Patent:

6627648, Sep 30, 2003

Filed:

Aug 13, 2001

Appl. No.:

09/928984

Inventors:

Gary Maurice Dull - Lewisville NC
Erin E. Reich - Nashville TN
Jared Miller Wagner - Stillwater OK
Balwinder Singh Bhatti - Winston-Salem NC
Michael B. Consilvio - Potomac MD

Assignee:

Targacept, Inc. - Winston-Salem NC

International Classification:

A61K 3144

US Classification:

514351, 514357, 546300, 546315, 546334

Abstract:

Patients susceptible to or suffering from conditions and disorders, such as central nervous system disorders, are treated by administering to a patient in need thereof aryloxyalkylamines and arylthioalkylamines, including pyridyloxyl-alkylamines, phenoxyalkylamines, pyridylthiolalkylamines and phenylthio-alkylamines. Exemplary compounds include (2-(5-bromo(3-pyridylthio))-ethyl)methylamine, (2-(5-bromo(3-pyridylthio))isopropyl)methylamine, (2-(5-bromo(3-pyridylthio))propyl)methylamine, (3-(5-bromo(3-pyridylthio))-propyl)methylamine, 3-((3S)-3-pyrrolidinyloxy)pyridine, 3-(4-piperidinyloxy)pyridine, 3-(1-methyl-4-piperidinyloxy)pyridine, (3-benzo[3,4-d]1,3-dioxolan-5-yloxypropyl)methylamine, and methyl(3-tricyclo[7. 3. 1. 05,13 ]tridec-2-yloxypropyl)amine.

US Patent:

6958399, Oct 25, 2005

Filed:

May 25, 2004

Appl. No.:

10/853602

Inventors:

William Scott Caldwell - Winston-Salem NC, US
Gary Maurice Dull - Lewisville NC, US
Balwinder Singh Bhatti - Winston-Salem NC, US
Srishailkumar B. Hadimani - Winston-Salem NC, US
Haeil Park - Kangwon-do, KR
Jared Miller Wagner - Durham NC, US
Peter Anthony Crooks - Lexington KY, US

Assignee:

Targacept, Inc. - Winston-Salem NC

International Classification:

C07D213/02
A61K031/44
A61P025/28

US Classification:

546290, 546297, 514351

Abstract:

Compounds incorporating aryl substituted olefinic amine are provided. Representative compounds are (4E)-N-methyl-5-(3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-pyrimidinyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-methoxy-3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(6-amino-5-methyl-3-pyridyl)-4-penten-2-amine, (2R)-(4E)-N-methyl-5-(3-pyridyl)-4-penten-2-amine, (2R)-(4E)-N-methyl-5-(5-isopropoxy-3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-bromo-3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-ethoxy-3-pyridyl)-4-penten-2-amine, (2S)-(4E)-N-methyl-5-(3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-isopropoxy-3-pyridyl)-4-penten-2-amine and (2S)-(4E)-N-methyl-5-(5-isopropoxy-3-pyridyl)-4-penten-2-amine.

US Patent:

6979695, Dec 27, 2005

Filed:

Oct 2, 2002

Appl. No.:

10/263083

Inventors:

William S. Caldwell - Winston Salem NC, US
Gary M. Dull - Lewisville NC, US
Balwinder S. Bhatti - Winston-Salem NC, US
Srishailkumar B. Hadimani - Oak Creek WI, US
Haeil Park - Kangwon-do, KR
Jared M. Wagner - Stillwater OK, US
Peter A. Crooks - Nicholasville KY, US
Patrick M. Lippiello - Lewisville NC, US
Merouane Bencherif - Winston-Salem NC, US

Assignee:

Targacept, Inc. - Winston-Salem NC

International Classification:

C07D213/38
C07D213/65
A61K031/44
A61K031/4427
A61P025/28

US Classification:

514344, 514345, 514357, 544300, 544297

Abstract:

The present invention generally relates to nicotinic compounds, in the form of aryl substituted olefinic compounds, as well as pro-drug, N-oxide, metabolite and pharmaceutically acceptable salt forms thereof. Methods of modulating neurotransmitter release via administration of the compounds, pro-drugs, N-oxides and/or pharmaceutically acceptable salts are also disclosed.

US Patent:

7045538, May 16, 2006

Filed:

Oct 22, 2004

Appl. No.:

10/971543

Inventors:

William S. Caldwell - Winston Salem NC, US
Gary M. Dull - Lewisville NC, US
Balwinder S. Bhatti - Winston-Salem NC, US
Srishailkumar B. Hadimani - Oak Creek WI, US
Haeil Park - Kangwon-do, KR
Jared M. Wagner - Stillwater OK, US
Peter A. Crooks - Nicholasville KY, US
Patrick M. Lippiello - Lewisville NC, US
Merouane Bencherif - Winston-Salem NC, US

Assignee:

Targacept, Inc. - Winston-Salem NC

International Classification:

C07D 213/38
A61K 31/44
A61P 29/02

US Classification:

514351, 546290, 546297

Abstract:

The present invention generally relates to nicotinic compounds, in the form of aryl substituted olefinic compounds, as well as pro-drug, N-oxide, metabolite and pharmaceutically acceptable salt forms thereof. Methods of modulating neurotransmitter release via administration of the compounds, pro-drugs, N-oxides and/or pharmaceutically acceptable salts are also disclosed.

US Patent:

7060826, Jun 13, 2006

Filed:

Jul 14, 2005

Appl. No.:

11/181055

Inventors:

William Scott Caldwell - Winston-Salem NC, US
Gary Maurice Dull - Lewisville NC, US
Balwinder Singh Bhatti - Winston-Salem NC, US
Srishailkumar B. Hadimani - Winston-Salem NC, US
Haeil Park - Kangwon-do, KR
Jared Miller Wagner - Durham NC, US
Peter Anthony Crooks - Lexington KY, US

Assignee:

Targaeept, Inc. - Winston-Salem NC

International Classification:

C07D 239/24
A61K 31/506
A61P 25/28

US Classification:

544301, 514256

Abstract:

Compounds incorporating aryl substituted olefinic amine are provided. Representative compounds are (4E)-N-methyl-5-(3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-pyrimidinyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-methoxy-3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(6-amino-5-methyl-3-pyridyl)-4-penten-2-amine, (2R)-(4E)-N-methyl-5-(3-pyridyl)-4-penten-2-amine, (2R)-(4E)-N-methyl-5-(5-isopropoxy-3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-bromo-3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-ethoxy-3-pyridyl)-4-penten-2-amine, (2S)-(4E)-N-methyl-5-(3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-isopropoxy-3-pyridyl)-4-penten-2-amine and (2S)-(4E)-N-methyl-5-(5-isopropoxy-3-pyridyl)-4-penten-2-amine.

US Patent:

7307092, Dec 11, 2007

Filed:

Apr 20, 2006

Appl. No.:

11/379443

Inventors:

William Scott Caldwell - Winston-Salem NC, US
Gary Maurice Dull - Lewisville NC, US
Balwinder Singh Bhatti - Winston-Salem NC, US
Srishailkumar B. Hadimani - Winston-Salem NC, US
Haeil Park - Kangwon-do, KR
Jared Miller Wagner - Durham NC, US
Peter Anthony Crooks - Lexington KY, US

Assignee:

Targacept, Inc. - Winston-Salem NC

International Classification:

A61K 31/44
A61P 25/28
A61P 25/18
A61P 25/16
A61P 25/14
C07D 213/02

US Classification:

514345, 514351, 546290, 546297, 546300

Abstract:

Compounds incorporating aryl substituted olefinic amine are provided. Representative compounds are (4E)-N-methyl-5-(3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-pyrimidinyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-methoxy-3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(6-amino-5-methyl-3-pyridyl)-4-penten-2-amine, (2R)-(4E)-N-methyl-5-(3-pyridyl)-4-penten-2-amine, (2R)-(4E)-N-methyl-5-(5-isopropoxy-3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-bromo-3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-ethoxy-3-pyridyl)-4-penten-2-amine, (2S)-(4E)-N-methyl-5-(3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-isopropoxy-3-pyridyl)-4-penten-2-amine and (2S)-(4E)-N-methyl-5-(5-isopropoxy-3-pyridyl)-4-penten-2-amine.