Jason Edward Gestwicki from 594 Kelmore St, Moss Beach, CA 94038, age 50

Name / Title

Company / Classification

Phones & Addresses

Jason Gestwicki
Manager

Stanford University
College/University

269 Campus Dr, Palo Alto, CA 94305
PO Box 362, Brookdale, CA 95007

Us Patents

Binding Protein As Biosensors
view source
US Patent:

7064103, Jun 20, 2006
Filed:

Jan 4, 2002
Appl. No.:

10/039799
Inventors:

J. Bruce Pitner - Durham NC, US
Jason E. Gestwicki - Mountain View CA, US
Zachary A. Pfieffer - Madison WI, US
Helen V. Hsieh - Durham NC, US
Assignee:

Becton, Dickinson and Company - Franklin Lakes NJ
International Classification:

A61K 38/00
US Classification:

514 2, 435 14, 435 23, 435 25, 536 111
Abstract:

The invention is directed to compositions of mutated binding proteins containing thiol groups for coupling to sensor surfaces, analyte biosensor devices derived there from, and methods of their use as analyte biosensors both in vitro and in vivo.

Binding Protein As Biosensors
view source
US Patent:

7316909, Jan 8, 2008
Filed:

Jun 19, 2006
Appl. No.:

11/424892
Inventors:

J. Bruce Pitner - Durham NC, US
Jason E. Gestwicki - Mountain View CA, US
Zachary A. Pfieffer - Madison WI, US
Helen V. Hsieh - Durham NC, US
Assignee:

Becton, Dickinson and Company - Franklin Lakes NJ
International Classification:

G01N 33/53
US Classification:

435 71, 514 2
Abstract:

The invention is directed to compositions of mutated binding proteins containing thiol groups for coupling to sensor surfaces, analyte biosensor devices derived there from, and methods of their use as analyte biosensors both in vitro and in vivo.

Binding Proteins As Biosensors
view source
US Patent:

7326538, Feb 5, 2008
Filed:

Jun 19, 2006
Appl. No.:

11/424894
Inventors:

J. Bruce Pitner - Durham NC, US
Jason E. Gestwicki - Mountain View CA, US
Zachary A. Pfieffer - Madison WI, US
Helen V. Hsieh - Durham NC, US
Assignee:

Becton Dickinson and Company - Franklin Lakes NJ
International Classification:

G01N 33/53
US Classification:

435 71, 4352872
Abstract:

The invention is directed to compositions of mutated binding proteins containing thiol groups for coupling to sensor surfaces, analyte biosensor devices derived there from, and methods of their use as analyte biosensors both in vitro and in vivo.

Neurodegenerative Protein Aggregation Inhibition Methods And Compounds
view source
US Patent:

7485706, Feb 3, 2009
Filed:

Jul 28, 2004
Appl. No.:

10/901848
Inventors:

Isabella A. Graef - Woodside CA, US
Gerald R. Crabtree - Woodside CA, US
Jason E. Gestwicki - Mountain View CA, US
Assignee:

The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA
International Classification:

C07D 498/18
C07D 417/02
C07D 211/60
C12N 9/00
C12Q 1/00
A01N 37/18
US Classification:

534797, 540456, 546197
Abstract:

Methods and compositions are provided for reducing aggregation of neurodegenerative proteins associated with neurotoxicity or other proteins. The compounds comprise a first domain or targeting element for binding to the target proteins linked to a second domain or recruiting element that binds to an aggregation inhibiting protein, e. g. a prolyl isomerase. By associating the aggregating forming proteins or neuronal cells under conditions where aggregating proteins are produced with the compound and the aggregation inhibiting protein, aggregation is reduced. The subject agents can be used in assays, investigating the etiology of the neuronal diseases and for prophylaxis and therapy.

Neurodegenerative Protein Aggregation Inhibition Methods And Compounds
view source
US Patent:

7923230, Apr 12, 2011
Filed:

Mar 17, 2008
Appl. No.:

12/050017
Inventors:

Isabella A. Graef - Woodside CA, US
Gerald R. Crabtree - Woodside CA, US
Jason E. Gestwicki - Ann Arbor MI, US
Assignee:

The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA
International Classification:

C12N 9/00
C07D 498/18
C07D 417/02
C07D 211/60
US Classification:

435183, 534797, 540456, 546197
Abstract:

Methods and compositions are provided for reducing aggregation of neurodegenerative proteins associated with neurotoxicity or other proteins. The compounds comprise a first domain or targeting element for binding to the target proteins linked to a second domain or recruiting element that binds to an aggregation inhibiting protein, e. g. a prolyl isomerase. By associating the aggregating forming proteins or neuronal cells under conditions where aggregating proteins are produced with the compound and the aggregation inhibiting protein, aggregation is reduced. The subject agents can be used in assays, investigating the etiology of the neuronal diseases and for prophylaxis and therapy.

Analytical System With Photonic Crystal Sensor
view source
US Patent:

8497992, Jul 30, 2013
Filed:

Nov 11, 2009
Appl. No.:

12/616457
Inventors:

Jingyong Ye - Ann Arbor MI, US
Jason E. Gestwicki - Ann Arbor MI, US
Theodore B. Norris - Dexter MI, US
Assignee:

The Regents of The University of Michigan - Ann Arbor MI
International Classification:

G01N 21/55
US Classification:

356448, 356445
Abstract:

A system for determining whether interaction occurs between a trial substance and a target substance. The system includes a photonic crystal sensor having a photonic crystal structure and a defect member disposed adjacent the photonic crystal structure. The defect member defines an operative surface able to receive the target substance and the trial substance. The system further includes a light source that inputs a light signal to the photonic crystal structure and the defect member. The light signal is internally reflected, and a resultant output signal is outputted. The output signal relates to whether the trial substance interacts with the target substance at the operative surface. Furthermore, the system includes an identity detector that identifies the trial substance that interacts with the target substance.

Methods And Reagents For Regulation Of Cellular Responses In Biological Systems
view source
US Patent:

20030125262, Jul 3, 2003
Filed:

Mar 21, 2001
Appl. No.:

09/815296
Inventors:

Laura Kiessling - Madison WI, US
Laura Strong - Madison WI, US
Jason Gestwicki - Madison WI, US
Assignee:

WISCONSIN ALUMNI RESEARCH FOUNDATION - MADISON 53707-7365
International Classification:

A61K031/70
A61K038/00
US Classification:

514/023000, 514/002000
Abstract:

This invention provides multivalent ligands which carry or display at least one recognition element (RE), and preferably a plurality of recognition elements, for binding directly or indirectly to cells or other biological particles or more generally by binding to any biological molecule. The multivalent ligands provided can most generally function for binding or targeting to any biological particle or molecule and particularly to targeting of cells or cell types or viruses, for cell aggregation and generally for macromolecular assembly of biological macromolecules. The multivalent ligands of this invention are generally applicable for creating scaffolds (assemblies) of chemical or biological species, including without limitation, antigens, epitopes, ligand binding groups, ligands for cell receptors (cell surface receptors, transmembrane receptors and cytoplasmic receptors), and various macromolecules (nucleic acids, carbohydrates, saccharides, proteins, peptides, etc.). In these scaffolds, the number, spacing, relative positioning and relative orientation of recognition elements can be controlled. Multivalent ligands of this invention can carry or display at least one signal recognition element (SRE), and preferably a plurality of signal recognition elements, and modulate biological responses in biological systems. The invention also relates to methods for aggregating biological particles and macromolecules and for modulating biological response employing the multivalent ligands provided.

Methods And Reagents For Regulation Of Cellular Responses In Biological Systems
view source
US Patent:

20040248801, Dec 9, 2004
Filed:

Mar 22, 2004
Appl. No.:

10/806056
Inventors:

Laura Kiessling - Madison WI, US
Byron Griffith - Madison WI, US
Jason Gestwicki - Mountain View CA, US
Laura Strong - Stoughton WI, US
International Classification:

A61K038/17
C12N015/85
US Classification:

514/012000, 435/455000
Abstract:

This invention provides multivalent ligands which carry or display at least one recognition element (RE), and preferably a plurality of recognition elements, for binding directly or indirectly to cells or other biological particles or more generally by binding to any biological molecule. The multivalent ligands provided can most generally function for binding or targeting to any biological particle or molecule and particularly to targeting of cells or cell types or viruses, for cell aggregation and generally for macromolecular assembly of biological macromolecules. The multivalent ligands of this invention are generally applicable for creating scaffolds (assemblies) of chemical or biological species, including without limitation, antigens, epitopes, ligand binding groups, ligands for cell receptors (cell surface receptors, transmembrane receptors and cytoplasmic receptors), and various macromolecules (nucleic acids, carbohydrates, saccharides, proteins, peptides, etc.). In these scaffolds, the number, spacing, relative positioning and relative orientation of recognition elements can be controlled. Multivalent ligands of this invention can carry or display at least one signal recognition element (SRE), and preferably a plurality of signal recognition elements, and modulate biological responses in biological systems. Multivalent ligands of this invention can carry or display at least one binding recognition element (BRE), and preferably a plurality of binding recognition elements, optionally in combination with one or more SRE, and modulate biological responses in biological systems. The invention also relates to methods for aggregating biological particles and macromolecules and for modulating biological response employing the multivalent ligands provided.