Magnus Pfahl - Solana Beach CA, US Catherine Tachdjian - San Diego CA, US Hussien Al-Shamma - Encinitas CA, US Andrea Fanjul - San Diego CA, US David Pleynet - San Diego CA, US Lyle Spruce - Chula Vista CA, US Torsten Wiemann - Cardiff By The Sea CA, US Jason Ibarra - Imperial Beach CA, US
International Classification:
C07F007/02 C 07D 4 3/02
US Classification:
546/014000, 546/268400, 546/272400, 546/272700
Abstract:
The invention relates to certain heterocyclic compounds useful for the treatment of cancer and other diseases, having the Formula (I): wherein: (a) m is an integer 0 or 1; (b) Ris an alkyl, a substituted alkyl, a cycloalkyl, a substituted cycloalkyl, a heterocyclic, a substituted heterocyclic, a heteroaryl, a substituted heteroaryl, an aryl or a substituted aryl residue; (c) Aris an aryl, a substituted aryl, a heteroaryl or a substituted heteroaryl residue; (d) Aris an aryl, a substituted aryl, a heteroaryl or a substituted heteroaryl residue; (e) Ris hydrogen, hydroxy, alkyl or substituted alkyl; (f) - - - - - represents a bond present or absent; and (g) W, X, Y and Z are independently or together C(O)—, C(S), S, O, or NH; or a pharmaceutically acceptable salt thereof.
N-Biaryl And N-Arylheteroaryl Piperazine Derivatives As Modulators Of The 5Ht2C Receptor Useful For The Treatment Of Disorders Related Thereto
Brian M. Smith - San Diego CA, US Vincent J. Santora - Carlsbad CA, US Rena Hayashi - San Diego CA, US Jason B. Ibarra - Las Vegas NV, US Jeffrey A. Schultz - San Diego CA, US Scott A. Estrada - La Jolla CA, US
The present invention relates to certain biarylz and arylheteroaryl piperazine derivatives of Formula (Ia) that are modulators of the 5HTreceptor. Accordingly, compounds of the present invention are useful for the treatment of 5HTreceptor associated diseases or disorders, such as, obesity, Alzheimer Disease, erectile dysfunction and related disorders.
N-Biaryl And N-Arylheteroaryl 2-Substituted Piperazine Derivatives As Modulators Of The 5Ht2C Receptor Useful For The Treatment Of Disorders Related Thereto
Brian M Smith - San Diego CA, US Vincent J. Santora - Carlsbad CA, US Rena Hayashi - San Diego CA, US Jason B. Ibarra - Las Vegas NV, US Jeffrey A. Schultz - San Diego CA, US Scott A. Estrada - La Jolla CA, US
The present invention relates to certain N-biaryl and N-arylheteroaryl 2-substituted piperazine derivatives of Formula (Ia) that are modulators of the 5HT2C receptor. Accordingly, compounds of the present invention are useful for the treatment of 5HT2C receptor associated diseases or disorders, such as, obesity, Alzheimer Disease, erectile dysfunction and related disorders.
Pyrazolyl Substituted Carbonic Acid Derivatives As Modulators Of The Prostacyclin (Pgi2) Receptor Useful For The Treatment Of Disorders Related Thereto
Thuy-Anh Tran - San Diego CA, US Jason B. Ibarra - Las Vegas NV, US Young-Jun Shin - San Diego CA, US Brett Ullman - San Diego CA, US Ning Zou - San Diego CA, US Xi Zeng - San Diego CA, US
Pyrazole derivatives of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the PGI2 receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of: pulmonary arterial hypertension (PAH) and related disorders; platelet aggregation; coronary artery disease; myocardial infarction; transient ischemic attack; angina; stroke; ischemia-reperfusion injury; restenosis; atrial fibrillation; blood clot formation in an angioplasty or coronary bypass surgery individual or in an individual suffering from atrial fibrillation; atherosclerosis; atherothrombosis; asthma or a symptom thereof; a diabetic-related disorder such as diabetic peripheral neuropathy, diabetic nephropathy or diabetic retinopathy; glaucoma or other disease of the eye with abnormal intraocular pressure; hypertension; inflammation; psoriasis; psoriatic arthritis; rheumatoid arthritis; Crohn's disease; transplant rejection; multiple sclerosis; systemic lupus erythematosus (SLE); ulcerative colitis; ischemia-reperfusion injury; restenosis; atherosclerosis; acne; type 1 diabetes; type 2 diabetes; sepsis; and chronic obstructive pulmonary disorder (COPD).
Modulators Of The Prostacyclin (Pgi2) Receptor Useful For The Treatment Of Disorders Related Thereto
Thuy-Anh Tran - San Diego CA, US Rena Hayashi - Hacienda Heights CA, US Jason B. Ibarra - Las Vegas NV, US Brett Ullman - San Diego CA, US Ning Zou - San Diego CA, US
Cyclohexane derivatives of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the PGI2 receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of: pulmonary arterial hypertension (PAH) and related disorders; platelet aggregation; coronary artery disease; myocardial infarction; transient ischemic attack; angina; stroke; ischemia-reperfusion injury; restenosis; atrial fibrillation; blood clot formation in an angioplasty or coronary bypass surgery individual or in an individual suffering from atrial fibrillation; atherosclerosis; atherothrombosis; asthma or a symptom thereof; a diabetic-related disorder such as diabetic peripheral neuropathy, diabetic nephropathy or diabetic retinopathy; glaucoma or other disease of the eye with abnormal intraocular pressure; hypertension; inflammation; psoriasis; psoriatic arthritis; rheumatoid arthritis; Crohn's disease; transplant rejection; multiple sclerosis; systemic lupus erythematosus (SLE); ulcerative colitis; ischemia-reperfusion injury; restenosis; atherosclerosis; acne; type 1 diabetes; type 2 diabetes; sepsis; and chronic obstructive pulmonary disorder (COPD).
Modulators Of The Prostacyclin (Pgi2) Receptor Useful For The Treatment Of Disorders Related Thereto
Thuy-Anh Tran - San Diego CA, US Rena Hayashi - Hacienda Heights CA, US Jason B. Ibarra - Las Vegas NV, US Brett Ullman - San Diego CA, US Ning Zou - San Diego CA, US
Cyclohexane derivatives of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the PGI2 receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of: pulmonary arterial hypertension (PAH) and related disorders; platelet aggregation; coronary artery disease; myocardial infarction; transient ischemic attack; angina; stroke; ischemia-reperfusion injury; restenosis; atrial fibrillation; blood clot formation in an angioplasty or coronary bypass surgery individual or in an individual suffering from atrial fibrillation; atherosclerosis; atherothrombosis; asthma or a symptom thereof; a diabetic-related disorder such as diabetic peripheral neuropathy, diabetic nephropathy or diabetic retinopathy; glaucoma or other disease of the eye with abnormal intraocular pressure; hypertension; inflammation; psoriasis; psoriatic arthritis; rheumatoid arthritis; Crohn's disease; transplant rejection; multiple sclerosis; systemic lupus erythematosus (SLE); ulcerative colitis; ischemia-reperfusion injury; restenosis; atherosclerosis; acne; type 1 diabetes; type 2 diabetes; sepsis; and chronic obstructive pulmonary disorder (COPD).
Jason Ibarra (1994-1998), Jennifer Allen (1998-2002), Joe Dodge (2002-2006), John Butler (2000-2004), Jose Mendoza (2004-2008), Heidi Hewitt (1998-2002)
Hi, I'm Jason. I love being creative and playing sports. I like to have fun and take long walks on the beach. Fitness is my new obsession. I'd love to get to know you.
Tagline:
I just need someone to talk to...
Bragging Rights:
A wise man once told me, "You have to want something more than you want to breathe."
Jason Ibarra
Education:
Savannah College of Art and Design - Sequential Art
About:
Hello I am a 26 year old visual artist and musician!