Novel hydroxamic acid compounds are disclosed. These hydroxamates inhibit peptide deformylase (PDF), an enzyme present in prokaryotes and are therefore useful as antimicrobials and antibiotics. Methods of synthesis and of use of the compounds are also disclosed.
Pyrrolidine Bicyclic Compounds And Its Derivatives, Compositions And Methods Of Use
Jeffrey Jacobs - San Mateo CA, US Rakesh K. Jain - Fremont CA, US Jason G. Lewis - Hayward CA, US Dinesh V. Patel - Fremont CA, US Zhengyu Yuan - Fremont CA, US
N-[1-oxo-(optionally 2-aza)-2-alkyl-3-(carboxyl or thiol or hydroxyaminocarbonyl or N-hydroxyformamido)-propyl]-(aryl or heteroaryl)-azacycloalkanes or thiazacycloalkanes, salts or prodrugs thereof have interesting properties, e. g. , in the treatment or prevention of disorders amenable to treatment by PDF inhibitors, such as treatment of bacterial infections.
Jason Lewis - Hayward CA, US Dinesh V. Patel - Fremont CA, US Sampath K. Anandan - Fremont CA, US Mikhail F. Gordeev - Castro Valley CA, US
Assignee:
Vicuron Pharmaceuticals, Inc. - King of Prussia PA
International Classification:
C07H 15/26
US Classification:
536 165, 536 162
Abstract:
Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. As the compounds of the subject invention exhibit potent activities against bacteria, including gram positive organisms, they are useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.
Jason G. Lewis - Hayward CA, US Dinesh V. Patel - Fremont CA, US Sampath Kumar Anandan - Fremont CA, US Mikhail F. Gordeev - South San Francisco CA, US
Assignee:
Vicuron Pharmaceuticals, Inc. - King of Prussia PA
International Classification:
A61K 31/70 C07H 15/00
US Classification:
514 24, 536 162, 536 163
Abstract:
Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. As the compounds of the subject invention exhibit potent activities against bacteria, including gram positive organisms, they are useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.
Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. The compounds of the subject invention may exhibit potent activities against bacteria, including gram positive organisms, and may be useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.
Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. The compounds of the subject invention may exhibit potent activities against bacteria, including Gram positive organisms, and may be useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.
Pyrrolidine Bicyclic Compounds And Its Derivatives, Compositions And Methods Of Use
Jeffrey Jacobs - San Mateo CA, US Rakesh K Patel - Fremont CA, US Jason G Lewis - Hayward CA, US Dinesh V Patel - Fremont CA, US Zhengyu Yuan - Fremont CA, US
N-[1-oxo-(optionally 2-aza)-2-alkyl-3-(carboxyl or thiol or hydroxyaminocarbonyl or N-hydroxyformamido)-propyl]-(aryl or heteroaryl)-azacycloalkanes or thiazacycloalkanes, salts or prodrugs thereof have interesting properties, e. g. , in the treatment or prevention of disorders amenable to treatment by PDF inhibitors, such as treatment of bacterial infections.
Rakesh Kumar Jain - Fremont CA, US Mikhail Fedorovich Gordeev - Castro Valley CA, US Jason Gustaf Lewis - Castro Valley CA, US Charles Francavilla - Fremont CA, US
Described herein are N-hydroxyamide antibacterial compounds, methods for making the compounds, pharmaceutical compositions containing the compounds and methods of treating bacterial infections utilizing the compounds and pharmaceutical compositions compound of Formula (I): or a salt, solvate ti hydrate thereof, wherein A is (a) each indicates a point of attachment.
Dr. Lewis graduated from the SUNY Upstate Medical University in 2004. He works in Charlotte, NC and specializes in Gastroenterology. Dr. Lewis is affiliated with Carolinas Medical Center.
Kentucky Pain Associates 222 S 1 St STE 300, Louisville, KY 40202 (502)8553919 (phone), (502)8553918 (fax)
Commonwealth Pain Associates 1107 Crown Pointe Dr STE 107, Elizabethtown, KY 42701 (270)5063300 (phone), (270)5062843 (fax)
Commonwealth Pain Associates 120 Executive Park STE 120, Louisville, KY 40207 (502)8557200 (phone), (502)8557201 (fax)
Education:
Medical School University of Louisville School of Medicine Graduated: 2004
Languages:
English
Description:
Dr. Lewis graduated from the University of Louisville School of Medicine in 2004. He works in Louisville, KY and 2 other locations and specializes in Anesthesiology.
Jun 2008 to 2000 Executive Producer / DirectorLionsgate Entertainment Santa Monica, CA 2012 to 2012 Executive Assistant to Senior Executive Vice PresidentUniversal Pictures Universal City, CA Jan 2011 to May 2011 Executive Assistant to Creative Development Executive (NBC Page Rotational Assignment)NBC Universal - Digital Studio Universal City, CA Sep 2010 to Jan 2011 Executive Assistant to Executive Producer and to Director of Marketing (NBC Page Rotational Assignment)Fox Searchlight Pictures Los Angeles, CA 2011 to 2011 Executive Assistant to Chief Financial OfficerNBC Universal - Page Program Universal City, CA 2010 to 2011 NBC Page
Education:
Lynda.com San Francisco, CA 2014 to 2015 Search Engine Optimization (SEO)University of Hartford West Hartford, CT 2008 Bachelor of Science in Audio Engineering Technology
Skills:
Microsoft Office Suite (Word, Excel, PowerPoint, and Outlook), Google Analytics, Search Engine Optimization (SEO), LinkedIn, Twitter, Facebook, Google+, Instagram, Data Analytics, Apple Operating Systems: Lion, Mountain Lion and iOS, Filemaker Pro.
Aug 2011 to 2000 Hard Surface/Vehicle Modeler/Texture ArtistNutrition53
Apr 2009 to 2000 Graphic Design and MarketingFreelance Berkeley, CA Sep 2010 to Jul 2011 Hair Simulation Artist and Dynamics ArtistFreelance Los Angeles, CA Aug 2010 to Dec 2010 Character Modeler and Texture Artist "Greedic"Expo Design Center Dublin, CA Apr 2006 to Feb 2009 Designer/Environmental ModelerFreelance Emeryville, CA Oct 2007 to Oct 2007 Environmental Modeler and Texture Artist
Education:
Ex'pression College For Digital Arts Emeryville, CA Jan 2004 to Jan 2007 BAS Computer Animation and Visual Effects in Modeling and Texture Art
Skills:
3D Modeling, Texture Art, Shader Writing, Custom Paint Textures, Graphic Design, Video Editing
2006 to 2000 Redeemer Missionary Baptist ChurchWalgreens
2005 to 2000 Store Team Lead/Store Operations/Operations & Community ManagementBank of America Los Angeles, CA 2003 to 2005 Universal Teller/Personal BankerGreater Bethel Missionary Baptist Church Richmond, CA 2001 to 2002 Administrative Assistant
Education:
Faith Evangelical College and Seminary Tacoma, WA 2010 to 2014 BA in Theories and styles of leadership
Skills:
Microsoft Word (Document Preparation), Excel (Spreadsheet Preparation), PowerPoint (Slide Show Presentation Preparation), Microsoft Publisher, QuickBooks (Bookkeeping/Employee Payroll Processing.
2010 to 2000 Executive Assistant to the PresidentWalgreens Bellflower, CA 2005 to 2011 Store Team Lead/Store Operations/Operations & Community ManagementRedeemer Missionary Baptist Church Los Angeles, CA 2006 to 2010 Youth PastorGreater Bethel Missionary Baptist Church Richmond, CA 2001 to 2002 Administrative Assistant
Education:
Faith Evangelical College and Seminary Tacoma, WA 2010 BA in Theories and styles of leadership
The imagery on our state seal and flag has long been viewed by indigenous people and others as racist, symbolizing white supremacy and ethnic cleansing perpetrated against the indigenous peoples of this region, said amendment sponsor Sen. Jason Lewis (D-Winchester). I was proud to sponsor and hel
Date: Jun 03, 2024
Category: Your local news
Source: Google
AG tightens regulatory reins over AI industry | North Of Boston | eagletribune.com
Another proposal, filed by Sen. Jason Lewis, D-Winchester, and Rep. Sean Garballey, D-Arlington, calls for setting up a state commission to look at how AI is being used by the state government. The measure, if approved, could lead to new regulations for the industry.
ality, affordable early education and childcare is essential for the healthy development of young children, as well as for the economic well-being of working families and employers in the commonwealth, said Sen. Jason Lewis (D-Winchester), lead sponsor and Senate Chair of the Committee on Education. WiThe bill already includes a new competitive grant program to incentivize employers to invest in additional early education and care slots for their employees, responded Sen. Jason Lewis who opposed the amendment. Furthermore, a federal tax credit has been available to employers since 2001 and
Date: Mar 16, 2024
Category: Your local news
Source: Google
Thieves steal girl's dad's ashes from doorstep in Ephrata
8-year-old Mia Lewis of Ephrata recently lost her father, 38-year-old Jason Lewis of Yakima, after his body was found somewhere near Snoqualmie Pass in mid-October after making the trek to western Washington for work in September. Mia's family is not divulging the details about his death for various
Date: Dec 05, 2023
Category: Health
Source: Google
Previously unreleased videos show Alec Baldwin firing prop gun with blanks and directing 'Rust' crew on safety
isnt clear how much of the footage prosecutors reviewed or whether they reviewed any of the five videos. NBC News asked Kari Morrissey one of two lead special prosecutors on the case with Jason Lewis which footage her team reviewed and whether any of it was involved in charging decisions. She d
Date: Nov 15, 2023
Category: Entertainment
Source: Google
POLITICO Playbook: Nine days out, and Penceworld has an outbreak
Senate landscape on FOX NEWS SUNDAY: This is a tight race, we know this, but the trend lines are good in these states. Youre seeing McSally gain momentum. You also didnt mention candidates like John James and Jason Lewis, who [have] competitive races against Democratic incumbents.
Date: Oct 25, 2020
Category: Headlines
Source: Google
Latest on COVID-19 in MN: Hospitalizations jump; 8 more deaths
Candidate Jason Lewis self-quarantines for 2nd time in week: Republican U.S. Senate candidate Jason Lewis left the campaign trail for the second time in less than a week Wednesday after learning that he had been in contact with a person who tested positive for the coronavirus.
Date: Oct 08, 2020
Category: More news
Source: Google
Republican Senate majority targets Tina Smith in Minnesota election
Now, shes on the ballot for a full six-year term of her own: Come November, Smith will face Republican Jason Lewis (known for once complaining that it was no longer socially acceptable to call women sluts).
Date: Sep 14, 2020
Category: Headlines
Source: Google
Googleplus
Jason Lewis
Work:
Bose - Demonstration Specialist Ourisman Toyota - Salesperson (6) Advance Auto Parts - Salesperson (4-11) J.Crew - Sales Support (2-7) Washington Redskins - Sales (11-1) Washington Bike Center - Customer Service (2-7) Target Corporation - Cashier (11-1)
Education:
George Mason University - Global Affairs, James W. Robinson Secondary School, University of Tennessee - Music Education, Indiana University Bloomington - Arabic
Tagline:
Passion
Bragging Rights:
Lost 70 Pounds
Jason Lewis
Education:
University of Phoenix - Web Design & Development, Penn State University - IST, Millersville University - Computer Science
About:
Geek and digital consumptionist. Â Interested in cross platform integration and social media. Â I'm currently trying to learn as much as I can about web development and web design. Â I have a nasty h...
Tagline:
Derp
Bragging Rights:
Remembers measuring baud rate and using "k" when talking about internet speed. Had a website with tags that said Hello World.
Jason Lewis
Work:
Temple Baptist Church - Youth Director (2008)
Education:
Louisiana Baptist University - Biblical Studies, Maranatha Baptist Bible college - Biblical Studies
Dr. Jason Lewis has committed himself to excellence in dentistry as a student, practitioner, and industry leader. He earned his dental degree from the University of Oklahoma, after earning his bachelo...
Tagline:
Dentist St. Johns FL - Bartram Dental Center
Bragging Rights:
Dr. Lewis stays active in the community by educating children at local elementary schools during dental health month. He also participates in the Halloween Candy Buyback program, giving trick-or-treaters a dollar per pound for extra candy. This candy is then mailed to our troops overseas.
Jason Lewis
Work:
Rich Couples Network - Founder and Trainer (2011)
Education:
North Georgia College and State University - Psychology
Bragging Rights:
Author of the book "Rich Couples Getting Back to Financial Basics"
Simple! I'm open minded,like's to hang out and have a good time, lime, meet people that kind of thing. I'm straight forward and will put no water in my mouth to say anything Don't like...
Jason Lewis
Work:
Rainin llc - Technician (2004)
Education:
Shyline high, Montara
Jason Lewis
Education:
Orbost Secondary College
Relationship:
In_a_relationship
About:
I'm a developer hailing from the land of the south. Australia! I've been doing web design and development since 2006. Mind you I was born in 1991. Anyhow. I've progressed a LOT since then ...
Tagline:
By day I fight fires, by night I fight blocks of code.
Bragging Rights:
Served at A Field Battery... even if for only a short period of time.