Novel hydroxamic acid compounds are disclosed. These hydroxamates inhibit peptide deformylase (PDF), an enzyme present in prokaryotes and are therefore useful as antimicrobials and antibiotics. Methods of synthesis and of use of the compounds are also disclosed.
Pyrrolidine Bicyclic Compounds And Its Derivatives, Compositions And Methods Of Use
Jeffrey Jacobs - San Mateo CA, US Rakesh K. Jain - Fremont CA, US Jason G. Lewis - Hayward CA, US Dinesh V. Patel - Fremont CA, US Zhengyu Yuan - Fremont CA, US
N-[1-oxo-(optionally 2-aza)-2-alkyl-3-(carboxyl or thiol or hydroxyaminocarbonyl or N-hydroxyformamido)-propyl]-(aryl or heteroaryl)-azacycloalkanes or thiazacycloalkanes, salts or prodrugs thereof have interesting properties, e. g. , in the treatment or prevention of disorders amenable to treatment by PDF inhibitors, such as treatment of bacterial infections.
Jason Lewis - Hayward CA, US Dinesh V. Patel - Fremont CA, US Sampath K. Anandan - Fremont CA, US Mikhail F. Gordeev - Castro Valley CA, US
Assignee:
Vicuron Pharmaceuticals, Inc. - King of Prussia PA
International Classification:
C07H 15/26
US Classification:
536 165, 536 162
Abstract:
Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. As the compounds of the subject invention exhibit potent activities against bacteria, including gram positive organisms, they are useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.
Jason G. Lewis - Hayward CA, US Dinesh V. Patel - Fremont CA, US Sampath Kumar Anandan - Fremont CA, US Mikhail F. Gordeev - South San Francisco CA, US
Assignee:
Vicuron Pharmaceuticals, Inc. - King of Prussia PA
International Classification:
A61K 31/70 C07H 15/00
US Classification:
514 24, 536 162, 536 163
Abstract:
Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. As the compounds of the subject invention exhibit potent activities against bacteria, including gram positive organisms, they are useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.
Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. The compounds of the subject invention may exhibit potent activities against bacteria, including gram positive organisms, and may be useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.
Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. The compounds of the subject invention may exhibit potent activities against bacteria, including Gram positive organisms, and may be useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.
Pyrrolidine Bicyclic Compounds And Its Derivatives, Compositions And Methods Of Use
Jeffrey Jacobs - San Mateo CA, US Rakesh K Patel - Fremont CA, US Jason G Lewis - Hayward CA, US Dinesh V Patel - Fremont CA, US Zhengyu Yuan - Fremont CA, US
N-[1-oxo-(optionally 2-aza)-2-alkyl-3-(carboxyl or thiol or hydroxyaminocarbonyl or N-hydroxyformamido)-propyl]-(aryl or heteroaryl)-azacycloalkanes or thiazacycloalkanes, salts or prodrugs thereof have interesting properties, e. g. , in the treatment or prevention of disorders amenable to treatment by PDF inhibitors, such as treatment of bacterial infections.
Rakesh Kumar Jain - Fremont CA, US Mikhail Fedorovich Gordeev - Castro Valley CA, US Jason Gustaf Lewis - Castro Valley CA, US Charles Francavilla - Fremont CA, US
Described herein are N-hydroxyamide antibacterial compounds, methods for making the compounds, pharmaceutical compositions containing the compounds and methods of treating bacterial infections utilizing the compounds and pharmaceutical compositions compound of Formula (I): or a salt, solvate ti hydrate thereof, wherein A is (a) each indicates a point of attachment.
Dr. Lewis graduated from the SUNY Upstate Medical University in 2004. He works in Charlotte, NC and specializes in Gastroenterology. Dr. Lewis is affiliated with Carolinas Medical Center.
Kentucky Pain Associates 222 S 1 St STE 300, Louisville, KY 40202 (502)8553919 (phone), (502)8553918 (fax)
Commonwealth Pain Associates 1107 Crown Pointe Dr STE 107, Elizabethtown, KY 42701 (270)5063300 (phone), (270)5062843 (fax)
Commonwealth Pain Associates 120 Executive Park STE 120, Louisville, KY 40207 (502)8557200 (phone), (502)8557201 (fax)
Education:
Medical School University of Louisville School of Medicine Graduated: 2004
Languages:
English
Description:
Dr. Lewis graduated from the University of Louisville School of Medicine in 2004. He works in Louisville, KY and 2 other locations and specializes in Anesthesiology.
2012 to 2000 Executive PastorFull Gospel Baptist Church Fellowship Los Angeles, CA 2012 to 2012 State Youth DirectorInterim PastorSt. Thomas, B.C, CA Jan 2011 to Apr 2011Redeemer MBC Los Angeles, CA 2006 to 2011
Education:
Cypress College Cypress, CA 2013 to 2000 educationFaith Evangelical College & Seminary Tacoma, WA 2010 to 2012
2013 to 2000 Floor ManagerDRIL-Quip Houston, TX 2012 to 2013 Machinist OperatorALLIED BARTON West Covina, CA 2008 to 2012 Security GuardUNITED PARCEL SERVICE Riverside, CA 2007 to 2008 Representative
Education:
Riverside Community College Moreno Valley, CA 2007 to 2009 Psychology, software EngineeringVista Del Lago High School Moreno Valley, CA 2003 to 2007 HIGH SCHOOL DIPLOMA
Skills:
Skilled at learning new concepts quickly, working well under pressure, and communicating ideas clearly and effectively. I aspire to hold a position where I can interact with customers and team members on a daily basis. I am a hard worker, organized, energetic and a team player. Four years of experience in the field of Customer service. Eight months experience driving a forklift, lifting, and handling material. Training in crane operating; this can be used to lift heavy parts into machines.
Jun 2014 to 2000 Vocational Education Center AdministratorErik Thoren Exceptional Care Khei, HI Apr 2013 to Oct 2013 Landscape Laborer/MaintenanceBrookstone Redondo Beach, CA Sep 2010 to Jan 2011 Seasonal Asst. Store ManagerFred Meyer Jeweler Torrance, CA Nov 2006 to Apr 2010 Sales Associate
Skills:
- Sales<br/> - Customer Service (live and over the phone)<br/> - Proficient in Microsoft Office (Word, Excel, PowerPoint, Outlook)<br/> - Experience in Microsoft Windows administration<br/> - Excellent organizational skills<br/> - Experience in handling busy inbound calls from multiple lines<br/> - Strong written and verbal communication <br/> - Inventory control <br/> - Shipping/receiving<br/> - Market analysis and evaluation
Fleet Feet Encino Sports Encino, CA Jun 2011 to Aug 2013 Store Manager /Buyer /Inventory ManagerBig 5 Sporting Goods Encino, CA Aug 2010 to Jun 2011 Assistant ManagerBig 5 Sporting Goods Reseda, CA Oct 2009 to Aug 2010 Manager TraineeFrontrunners Brentwood, CA Jul 2008 to Oct 2009 Retail Sales RepresentativeVA Runner Woodbridge, VA Jan 2008 to Jun 2008 ManagerMetro Run & Walk Falls Church, VA Apr 2003 to Dec 2007 Retail Sales Representative
Education:
Virginia Intermont College Bristol, VA Jan 2005 to May 2006 BachelorDodge City Community College Dodge City, KS Aug 2000 to Dec 2001 AssociatedPotomac Senior High School Dumfries, VA 2000 High School Diploma
Oct 2011 to 2000 Mental Health WorkerSilver Lake Medical Center Los Angeles, CA Mar 2011 to Oct 2011 Administrative Staffing CoordinatorSilver Lake Medical Center Los Angeles, CA Sep 2010 to Oct 2011 Certified Nursing AssistantLos Angeles International Airport Los Angeles, CA Apr 2008 to Apr 2009 Bus DriverAAHS Gift Store Los Angeles, CA May 2007 to Oct 2007 Customer Service Representative/CashierLos Angeles International Airport Los Angeles, CA Jul 2004 to Jan 2007 Baggage Security Officer/Porter
Aug 2001 to 2000 Appointment SchedulerMary Hospital Torrance, CA Aug 2010 to Aug 2011 PBX Switchboard OperatorPasadena Unified School District Pasadena, CA Oct 2001 to Oct 2001 Behavioral Aide
Education:
Blair High School Pasadena, CA 1999 DiplomaUniversity of Phoenix Gardena, CA Psychology
The imagery on our state seal and flag has long been viewed by indigenous people and others as racist, symbolizing white supremacy and ethnic cleansing perpetrated against the indigenous peoples of this region, said amendment sponsor Sen. Jason Lewis (D-Winchester). I was proud to sponsor and hel
Date: Jun 03, 2024
Category: Your local news
Source: Google
AG tightens regulatory reins over AI industry | North Of Boston | eagletribune.com
Another proposal, filed by Sen. Jason Lewis, D-Winchester, and Rep. Sean Garballey, D-Arlington, calls for setting up a state commission to look at how AI is being used by the state government. The measure, if approved, could lead to new regulations for the industry.
ality, affordable early education and childcare is essential for the healthy development of young children, as well as for the economic well-being of working families and employers in the commonwealth, said Sen. Jason Lewis (D-Winchester), lead sponsor and Senate Chair of the Committee on Education. WiThe bill already includes a new competitive grant program to incentivize employers to invest in additional early education and care slots for their employees, responded Sen. Jason Lewis who opposed the amendment. Furthermore, a federal tax credit has been available to employers since 2001 and
Date: Mar 16, 2024
Category: Your local news
Source: Google
Thieves steal girl's dad's ashes from doorstep in Ephrata
8-year-old Mia Lewis of Ephrata recently lost her father, 38-year-old Jason Lewis of Yakima, after his body was found somewhere near Snoqualmie Pass in mid-October after making the trek to western Washington for work in September. Mia's family is not divulging the details about his death for various
Date: Dec 05, 2023
Category: Health
Source: Google
Previously unreleased videos show Alec Baldwin firing prop gun with blanks and directing 'Rust' crew on safety
isnt clear how much of the footage prosecutors reviewed or whether they reviewed any of the five videos. NBC News asked Kari Morrissey one of two lead special prosecutors on the case with Jason Lewis which footage her team reviewed and whether any of it was involved in charging decisions. She d
Date: Nov 15, 2023
Category: Entertainment
Source: Google
POLITICO Playbook: Nine days out, and Penceworld has an outbreak
Senate landscape on FOX NEWS SUNDAY: This is a tight race, we know this, but the trend lines are good in these states. Youre seeing McSally gain momentum. You also didnt mention candidates like John James and Jason Lewis, who [have] competitive races against Democratic incumbents.
Date: Oct 25, 2020
Category: Headlines
Source: Google
Latest on COVID-19 in MN: Hospitalizations jump; 8 more deaths
Candidate Jason Lewis self-quarantines for 2nd time in week: Republican U.S. Senate candidate Jason Lewis left the campaign trail for the second time in less than a week Wednesday after learning that he had been in contact with a person who tested positive for the coronavirus.
Date: Oct 08, 2020
Category: More news
Source: Google
Republican Senate majority targets Tina Smith in Minnesota election
Now, shes on the ballot for a full six-year term of her own: Come November, Smith will face Republican Jason Lewis (known for once complaining that it was no longer socially acceptable to call women sluts).
Date: Sep 14, 2020
Category: Headlines
Source: Google
Googleplus
Jason Lewis
Work:
Bose - Demonstration Specialist Ourisman Toyota - Salesperson (6) Advance Auto Parts - Salesperson (4-11) J.Crew - Sales Support (2-7) Washington Redskins - Sales (11-1) Washington Bike Center - Customer Service (2-7) Target Corporation - Cashier (11-1)
Education:
George Mason University - Global Affairs, James W. Robinson Secondary School, University of Tennessee - Music Education, Indiana University Bloomington - Arabic
Tagline:
Passion
Bragging Rights:
Lost 70 Pounds
Jason Lewis
Lived:
Artesia, California Wichita, Kansas Coffeyville, Kansas Ft. Knox, Kentucky
Work:
Wolters Kluwer - TSR (2010) Sheplers - SEO (2007-2010) Norris Enterprises - SEO (2004-2007)
Education:
Cowley County Community College - Business Leadership
Relationship:
Married
Jason Lewis
Lived:
Los Angeles, CA Vacaville, CA
Work:
KJLH Radio Station - Radio Personality (2008) The Redeemer Church of L.A. - Executive Pastor (2002)
Education:
Faith Evangleical College & Seminary - Christian Leadership, University of Southern California - Center for Religion & Civic Culture
About:
At the age of 27, Jason Troy Lewis has been recognized as a prolific orator, radio personality and an influential leader who serves God with excellence and integrity. Â He serves as an Associate Pastor...
Tagline:
Preacher, Leader, Motivational Speaker, Radio Personality & Etiquette Expert
Jason Lewis
Lived:
New York, NY Brooklyn, NY Los Angeles, CA San Salvador, El Salvador
Education:
Mount Sinai School of Medicine - M.D., New York University - Individualized Study- Chemistry & Ethics
Owner of Run 2 Your Potential, LLC Personal Strength and Conditioning Coach USA Track and Field Certified Coach PCA Level 1 and 2 Certified Coach Multiple National Champion Multiple All-American (HIg...
Bragging Rights:
Www.Run2YourPotential.com
Jason Lewis
Education:
University of Phoenix - Web Design & Development, Penn State University - IST, Millersville University - Computer Science
About:
Geek and digital consumptionist. Â Interested in cross platform integration and social media. Â I'm currently trying to learn as much as I can about web development and web design. Â I have a nasty h...
Tagline:
Derp
Bragging Rights:
Remembers measuring baud rate and using "k" when talking about internet speed. Had a website with tags that said Hello World.