Jason M Reed

US Patent:

8599383, Dec 3, 2013

Filed:

May 6, 2009

Appl. No.:

12/436702

Inventors:

Michael A. Teitell - Tarzana CA, US
James K. Gimzewski - Topanga CA, US
Jason C. Reed - Los Angeles CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

G01N 21/00
G01J 3/45

US Classification:

356451, 356341

Abstract:

The present invention provides optical systems and methods for determining a characteristic of a cell, such as cell type, cellular response to a biochemical event, biological state and the like. The methods typically involve using interferometry to observe membrane properties in a cell and then use this information to determine one or more characteristics of a cell. The methods of the invention are useful for applications such as drug screening as well as diagnostic techniques.

US Patent:

20140080171, Mar 20, 2014

Filed:

Nov 25, 2013

Appl. No.:

14/088992

Inventors:

Jason C. Reed - Los Angeles CA, US
Michael A. Teitell - Tarzana CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

G01N 33/50

US Classification:

435 29, 4352887

Abstract:

The present invention provides optical systems and methods for determining a characteristic of a cell, such as cell type, cellular response to a biochemical event, biological state and the like. The methods typically involve using interferometry to observe membrane properties in a cell and then use this information to determine one or more characteristics of a cell. The methods of the invention are useful for applications such as drug screening as well as diagnostic techniques.

US Patent:

20180156779, Jun 7, 2018

Filed:

Oct 5, 2017

Appl. No.:

15/726285

Inventors:

- Oakland CA, US
Jason C. Reed - Los Angeles CA, US
Michael A. Teitell - Tarzana CA, US

International Classification:

G01N 33/50
G01J 3/453
G02B 21/32
G02B 21/00
G02B 5/126

Abstract:

The present invention provides optical systems and methods for determining a characteristic of a cell, such as cell type, cellular response to a biochemical event, biological state and the like. The methods typically involve using interferometry to observe membrane properties in a cell and then use this information to determine one or more characteristics of a cell. The methods of the invention are useful for applications such as drug screening as well as diagnostic techniques.

US Patent:

20140178865, Jun 26, 2014

Filed:

Aug 2, 2012

Appl. No.:

14/235547

Inventors:

Jason C. Reed - Los Angeles CA, US
Michael A. Teitell - Tarzana CA, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA

International Classification:

G01N 33/574
G01N 33/50

US Classification:

435 61, 435 29, 435 723

Abstract:

A central question in cancer therapy is how individual cells within a population of tumor cells respond to drugs designed to arrest their growth. However, the absolute growth of cells, their change in physical mass, whether cancerous or physiologic, is difficult to measure directly with traditional techniques. Embodiments of the invention provide live cell interferometry (LCI) for rapid, realtime quantification of cell mass in cells exposed to a changing environment. Overall, LCI provides a conceptual advance for assessing cell populations to identify, monitor, and measure single cell responses, such as to therapeutic drugs.