Jason M Reed

US Patent:

8566038, Oct 22, 2013

Filed:

Oct 17, 2006

Appl. No.:

11/582938

Inventors:

James K. Gimzewski - Topanga CA, US
Bhubaneswar Mishra - New York NY, US
Jason C. Reed - Richmond VA, US

Assignee:

The Regents of the University of California - Oakland CA
New York University - New York NY

International Classification:

G01Q 10/00
G01N 33/48

US Classification:

702 19, 977881

Abstract:

The present invention provides methods of detecting a nucleic acid analyte in a sample. The present invention further provides a method for assigning a profile of a feature to a nucleic acid. The present invention further provides a computer program product for use in a subject method. The present invention further provides a system for detecting a nucleic acid in a sample; and a system for assigning a profile of a feature to a nucleic acid. The present invention further provides a method for immobilizing a nucleic acid onto an insoluble support; and further provides insoluble support having nucleic acid(s) immobilized thereon. The present invention further provides a method of diagnosing a disorder or condition in an individual, where the method involves use of a subject method for detecting a nucleic acid analyte.

US Patent:

8599383, Dec 3, 2013

Filed:

May 6, 2009

Appl. No.:

12/436702

Inventors:

Michael A. Teitell - Tarzana CA, US
James K. Gimzewski - Topanga CA, US
Jason C. Reed - Los Angeles CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

G01N 21/00
G01J 3/45

US Classification:

356451, 356341

Abstract:

The present invention provides optical systems and methods for determining a characteristic of a cell, such as cell type, cellular response to a biochemical event, biological state and the like. The methods typically involve using interferometry to observe membrane properties in a cell and then use this information to determine one or more characteristics of a cell. The methods of the invention are useful for applications such as drug screening as well as diagnostic techniques.

US Patent:

20110013820, Jan 20, 2011

Filed:

Jun 16, 2010

Appl. No.:

12/817004

Inventors:

Jason C. Reed - Santa Monica CA, US
Bhubaneswar Mishra - Great Neck NY, US
Andrew Sundstrom - Brooklyn NY, US

International Classification:

G06K 9/46
G06K 9/00

US Classification:

382133, 382190, 382286

Abstract:

The present disclosure provides methods of measuring a property of a macromolecule. The methods generally involve applying an empirically learned correction term to a test metric to generate a high-accuracy measurement. The present disclosure further provides a computer program product and a computer system for carrying out a subject method.

US Patent:

20140080171, Mar 20, 2014

Filed:

Nov 25, 2013

Appl. No.:

14/088992

Inventors:

Jason C. Reed - Los Angeles CA, US
Michael A. Teitell - Tarzana CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

G01N 33/50

US Classification:

435 29, 4352887

Abstract:

The present invention provides optical systems and methods for determining a characteristic of a cell, such as cell type, cellular response to a biochemical event, biological state and the like. The methods typically involve using interferometry to observe membrane properties in a cell and then use this information to determine one or more characteristics of a cell. The methods of the invention are useful for applications such as drug screening as well as diagnostic techniques.

US Patent:

20180156779, Jun 7, 2018

Filed:

Oct 5, 2017

Appl. No.:

15/726285

Inventors:

- Oakland CA, US
Jason C. Reed - Los Angeles CA, US
Michael A. Teitell - Tarzana CA, US

International Classification:

G01N 33/50
G01J 3/453
G02B 21/32
G02B 21/00
G02B 5/126

Abstract:

The present invention provides optical systems and methods for determining a characteristic of a cell, such as cell type, cellular response to a biochemical event, biological state and the like. The methods typically involve using interferometry to observe membrane properties in a cell and then use this information to determine one or more characteristics of a cell. The methods of the invention are useful for applications such as drug screening as well as diagnostic techniques.

US Patent:

20140178865, Jun 26, 2014

Filed:

Aug 2, 2012

Appl. No.:

14/235547

Inventors:

Jason C. Reed - Los Angeles CA, US
Michael A. Teitell - Tarzana CA, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA

International Classification:

G01N 33/574
G01N 33/50

US Classification:

435 61, 435 29, 435 723

Abstract:

A central question in cancer therapy is how individual cells within a population of tumor cells respond to drugs designed to arrest their growth. However, the absolute growth of cells, their change in physical mass, whether cancerous or physiologic, is difficult to measure directly with traditional techniques. Embodiments of the invention provide live cell interferometry (LCI) for rapid, realtime quantification of cell mass in cells exposed to a changing environment. Overall, LCI provides a conceptual advance for assessing cell populations to identify, monitor, and measure single cell responses, such as to therapeutic drugs.