Jason F Rhubottom

US Patent:

20120221252, Aug 30, 2012

Filed:

Feb 24, 2012

Appl. No.:

13/404437

Inventors:

Robert E. HEINZ - San Diego CA, US
Dennis NEWELL - Fallbrook CA, US
David OPALSKY - San Diego CA, US
Jason RHUBOTTOM - Oceanside CA, US

Assignee:

GEN-PROBE INCORPORATED - SAN DIEGO CA

International Classification:

G06F 19/10

US Classification:

702 19

Abstract:

Systems and method for detecting optical signals, and for discriminating optical signals emitted by an emission moiety that is excited by an associated excitation signal from background signals and other optical noise, employing digital techniques for determining the portion of a detected optical signal having a modulation frequency corresponding to a modulation of the associated excitation signal.

US Patent:

20120261469, Oct 18, 2012

Filed:

May 17, 2010

Appl. No.:

13/320749

Inventors:

Craig B. Clark - San Diego CA, US
John M. Gilker - San Diego CA, US
Norbert D. Hagen - Carlsbad CA, US
Tom R. Horn - San Diego CA, US
Byron J. Knight - San Diego CA, US
David Opalsky - San Diego CA, US
Jason F. Rhubottom - Oceanside CA, US
Waldemar Lukhaub - Vaihingen/Enz, DE
Olaf Hörger - Neuenburg, DE

International Classification:

G06Q 90/00
B01L 9/06

US Classification:

235385

Abstract:

A structure () for holding sample-containing receptacles includes a cover () with holes formed therein through which the receptacles can be accessed with a substance transfer mechanism, such as a robotic pipettor. When the transfer mechanism is inserted into and then withdrawn from a receptacle, a string of viscous material may be suspended from the mechanism. A viscous string removal element () adjacent each opening () engages the string of viscous material and dislodges the string from the mechanism when the mechanism moves in a prescribed path with respect to the removal element. A sample rack configured to hold receptacles and to be inserted into the structure below the cover includes a sample rack having receptacle-receiving pockets, each with a resilient element and a positioning feature for holding receptacles of varying sizes in a predetermined position within the receptacle receiving pocket, and a cover including features for preventing a receptacle from being pulled out of its receptacle-receiving pocket when the transfer mechanism is withdrawn from the receptacle.

US Patent:

20120128451, May 24, 2012

Filed:

May 17, 2010

Appl. No.:

13/320746

Inventors:

Norbert D. Hagen - Carlsbad CA, US
Byron J. Knight - San Diego CA, US
David Opalsky - San Diego CA, US
Jason F. Rhubottom - Oceanside CA, US
Olaf Hörger - Neuenburg, DE
Heiko Sayer - Neuenburg, DE
Harald Thahedl - Wimsheim, DE
Stefan Habrich - Bad Wildbad, DE

Assignee:

STRATEC BIOMEDICAL AG - Birkenfeld-Graefenhausen
GEN-PROBE INCORPORATED - San Diego CA

International Classification:

B65G 47/00

US Classification:

41422202, 41422213, 414806

Abstract:

Systems for effecting transfer of reaction receptacles between modules of an instrument for performing multi-step analytical procedures and for adjusting for variations in the positions of such modules includes a receptacle carrier supported on a track on which the carrier translates between different modules located adjacent to the track. The carrier includes a receptacle distribution head supported on a receptacle carrier carriage. The distribution head includes a receptacle moving mechanism adapted to move receptacles into and out of the distribution head and into and out of a module. The carriage is engaged with the track and adapted for translation along the track. Drive systems effect powered translation of the carriage, powered elevation and rotation of the distribution head, and powered movement of receptacles into and out of the distribution head. A transfer position locating system automatically determines a receptacle transfer position of the receptacle carrier with respect to each module.

US Patent:

20210324445, Oct 21, 2021

Filed:

Jan 11, 2021

Appl. No.:

17/146110

Inventors:

- San Diego CA, US
David Opalsky - San Diego CA, US
Jason F. Rhubottom - Oceanside CA, US
Norbert D. Hagen - Carlsbad CA, US
Jennifer L. Tidd - Vista CA, US

Assignee:

Gen-Probe Incorporated - San Diego CA

International Classification:

C12Q 1/6806
G01N 35/04
B01L 3/00
B01L 7/00
C12Q 1/686

Abstract:

A diagnostic system is configured to perform first and second, different nucleic acid amplification reactions. The system includes a bulk reagent container compartment configured to store first bulk reagent container containing a first bulk reagent for performing sample preparation processes with a first subset and a second subset of a plurality of samples and a second bulk reagent container containing a second bulk reagent for performing the first nucleic acid amplification reaction. The system includes a unit-dose reagent compartment storing a unit-dose reagent pack including unit-dose reagents for performing the second nucleic acid amplification reaction. The system is configured to perform the sample preparation process using the first bulk reagent on the first and second subsets of the samples, perform the first nucleic acid amplification reaction using the second bulk reagent on the first subset of the samples, and perform the second nucleic acid amplification reaction using the unit-dose reagents on the second subset of the samples.

US Patent:

20210155978, May 27, 2021

Filed:

Jul 10, 2018

Appl. No.:

16/629818

Inventors:

- San Diego CA, US
Anne-Laure SHAPIRO - La Jolla CA, US
Ankur H. SHAH - San Diego CA, US
James T. TUGGLE - Oceanside CA, US
David OPALSKY - San Diego CA, US
Alberto A. LIO - San Diego CA, US
Timothy J. SCHEER - San Diego CA, US
Jason F. RHUBOTTOM - San Diego CA, US
David Aaron BUSE - San Diego CA, US

Assignee:

Gen-Probe Incorporated - San Diego CA

International Classification:

C12Q 1/6844

Abstract:

Systems and methods for performing a plurality of nucleic acid amplification assays in an automated analyzer. A first nucleic acid amplification assay of the plurality is performed in accordance with a first set of assay parameters which consist of system-defined parameters. And a second nucleic acid amplification assay of the plurality is performed in accordance with a second set of assay parameters which includes one or more user-defined parameters.

US Patent:

20210071242, Mar 11, 2021

Filed:

Jan 29, 2019

Appl. No.:

16/965896

Inventors:

- San Diego CA, US
Anne-Laure SHAPIRO - La Jolla CA, US
Jason F. RHUBOTTOM - San Diego CA, US
Alberto A. LIO - San Diego CA, US
Timothy J. SCHEER - San Diego CA, US
James T. TUGGLE - Oceanside CA, US
Ankur H. SHAH - San Diego CA, US
David OPALSKY - San Diego CA, US

Assignee:

Gen-Probe Incorporated - San Diego CA

International Classification:

C12Q 1/6844
G01N 35/00

Abstract:

A system, method and computer readable medium enabling a user to specify user-defined assay parameters of an assay protocol for processing a sample and causing a computer-controlled analyzer to perform an assay in accordance with the assay protocol.

US Patent:

20210017579, Jan 21, 2021

Filed:

Sep 29, 2020

Appl. No.:

17/036730

Inventors:

- San Diego CA, US
David Howard Combs - San Diego CA, US
Byron J. Knight - San Diego CA, US
Norbert D. Hagen - Carlsbad CA, US
David Opalsky - San Diego CA, US
Jason F. Rhubottom - Oceanside CA, US
Keith Moravick - Los Gatos CA, US
Tyler Moore - Los Gatos CA, US
Anita Prasad - Los Gatos CA, US
Bruce Richardson - Los Gatos CA, US

Assignee:

Gen-Probe Incorporated - San Diego CA

International Classification:

C12Q 1/6806
G01N 35/04
B01L 3/00
B01L 7/00
C12Q 1/686

Abstract:

A system for performing a nucleic acid amplification assay comprises a thermally-conductive receptacle holder with one or more receptacle wells, each conforming to an outer surface of a lower portion of a vial. A through-hole extends from an inner surface of each well to an outer surface of the holder. A thermal element is positioned proximal to the holder for altering a temperature of the holder. A signal detection module is configured to generate an excitation signal directed through the through-hole of the well and detect an optical emission from a fluid contained in the vial supported by the well. At least one well supports a capped vial containing a reagent for a nucleic acid amplification assay and including an opaque cap sealing an open end of the vial. The lower portion of the vial is contained within a well, and the cap is situated above a top surface of the holder.

US Patent:

20190284612, Sep 19, 2019

Filed:

Mar 25, 2019

Appl. No.:

16/363671

Inventors:

- San Diego CA, US
David Opalsky - San Diego CA, US
Jason F. Rhubottom - Oceanside CA, US
Norbert D. Hagen - Carlsbad CA, US
Jennifer L. Tidd - Vista CA, US

Assignee:

Gen-Probe Incorporated - San Diego CA

International Classification:

C12Q 1/6806
C12Q 1/686
B01L 7/00
B01L 3/00
G01N 35/04

Abstract:

An automated method for analyzing a plurality of samples within a housing of a self-contained system. The system is loaded with a plurality of samples, after which a first assay is performed on a first sample subset and a second assay performed on a second sample subset. The two assays include exposing the samples to a target capture reagent having a solid support for directly or indirectly immobilizing a target nucleic acid that may be present in one or more of the samples. The two assays may be performed with the same or different target capture reagents and target nucleic acids, but the receptacles for performing the exposing step have substantially identical geometries. Following the exposing step, an amplification reaction for amplifying a region of the target nucleic acid is performed with each sample. The amplification reactions of the two assays are performed in receptacles having different geometries.