Jason L Watkins

US Patent:

20160282357, Sep 29, 2016

Filed:

Mar 31, 2016

Appl. No.:

15/086935

Inventors:

- Greenville SC, US
Frank Anderson Norris - Anderson SC, US
Jason Derrick Watkins - Greenville SC, US

International Classification:

G01N 33/58
G01N 21/64
C12Q 1/68

Abstract:

Small molecule fluorescent probes for established drug targets such as nucleic acids including DNA and RNA has been developed and disclosed herein. These nucleic acid probes bind to multiple DNA and RNA structures, and to sites crucial for nucleic acid function, such as DNA and RNA major grooves. Displacement of the probes by other binders such as small molecule compounds and/or proteins illicits a fluorescence change in the probe that once detected and analyzed provide binding information of these other binders of interest. Similarly, changes in fluorescence upon binding of the probes to nucleic acid have been applied to screen nucleic acid of different sequence and conformation. The nucleic acid probes and method of uses disclosed herein are advantageously suitable for high-through put screening of libraries of small molecule compounds, proteins, and nucleic acids.

US Patent:

20140330001, Nov 6, 2014

Filed:

Apr 11, 2014

Appl. No.:

14/251023

Inventors:

- Greenville SC, US
Frank Anderson Norris - Anderson SC, US
Jason Derrick Watkins - Greenville SC, US

Assignee:

Nubad, LLC - Greenville SC

International Classification:

C12Q 1/68

US Classification:

536 132, 536 137, 536 136

Abstract:

Small molecule fluorescent probes for established drug targets such as nucleic acids including DNA and RNA has been developed and disclosed herein. These nucleic acid probes bind to multiple DNA and RNA structures, and to sites crucial for nucleic acid function, such as DNA and RNA major grooves. Displacement of the probes by other binders such as small molecule compounds and/or proteins illicits a fluorescence change in the probe that once detected and analyzed provide binding information of these other binders of interest. Similarly, changes in fluorescence upon binding of the probes to nucleic acid have been applied to screen nucleic acid of different sequence and conformation. The nucleic acid probes and method of uses disclosed herein are advantageously suitable for high-through put screening of libraries of small molecule compounds, proteins, and nucleic acids.

Address:

3210 Louisiana St APT 1330, Houston, TX 77006

VIN:

4S3BL616677211081

Make:

SUBARU

Model:

LEGACY

Year:

2007