Jay Norman Zemel

US Patent:

6551841, Apr 22, 2003

Filed:

Jan 27, 1999

Appl. No.:

09/237523

Inventors:

Peter Wilding - Paoli PA
Larry J. Kricka - Berwyn PA
Jay N. Zemel - Jenkintown PA

Assignee:

The Trustees of the University of Pennsylvania - Philadelphia PA

International Classification:

G01N 33543

US Classification:

436518, 422 55, 422 57, 422 58, 435 6, 435 72, 435 721, 4352871, 4352872, 4352879, 4352884, 4352885, 4352887, 435810, 436164, 436514, 436524, 436527, 436531, 436533, 436534, 436805, 436806, 436807, 436809

Abstract:

Disclosed are devices for detecting the presence of a preselected analyte in a fluid sample. The devices comprise a substrate microfabricated to define a sample inlet port, and a mesoscale flow system that includes a sample flow channel extending from the inlet port. The mesoscale flow system further includes an analyte detection region in fluid communication with the flow channel comprised of a binding moiety for specifically binding the analyte. The detection region is constructed with a mesoscale dimension sufficiently small to enhance binding of the binding moiety and the analyte. The binding moiety may be immobilized in the detection region. The mesoscale detection systems of the invention may be used in a wide range of applications, including the detection of cells or macromolecules, or for monitoring reactions or cell culture growth.

US Patent:

7005292, Feb 28, 2006

Filed:

Aug 22, 2003

Appl. No.:

10/646678

Inventors:

Peter Wilding - Paoli PA, US
Larry J. Kricka - Berwyn PA, US
Jay N. Zemel - Jenkintown PA, US

Assignee:

The Trustees of the University of Pennsylvania - Philadelphia PA

International Classification:

C12M 3/00

US Classification:

4352871, 422 55, 422 56, 422 57, 422 58, 435 6, 435 72, 435 721, 4352879, 4352884, 4352885, 4352887, 435810, 436164, 436514, 436518, 436524, 436525, 436526, 436527, 436531, 436533, 436534, 436805, 436806, 436807, 436809

Abstract:

Disclosed are devices for detecting the presence of a preselected analyte in a fluid sample. The devices comprise a substrate microfabricated to define a sample inlet port, and a mesoscale flow system that includes a sample flow channel extending from the inlet port. The mesoscale flow system further includes an analyte detection region in fluid communication with the flow channel comprised of a binding moiety for specifically binding the analyte. The detection region is constructed with a mesoscale dimension sufficiently small to enhance binding of the binding moiety and the analyte. The binding moiety may be immobilized in the detection region. The mesoscale detection systems of the invention may be used in a wide range of applications, including the detection of cells or macromolecules, or for monitoring reactions or cell culture growth.

US Patent:

7018830, Mar 28, 2006

Filed:

Jan 21, 2003

Appl. No.:

10/348438

Inventors:

Peter Wilding - Paoli PA, US
Larry J. Kricka - Berwyn PA, US
Jay N. Zemel - Jenkintown PA, US

Assignee:

The Trustees of the University of Pennsylvania - Philadelphia PA

International Classification:

C12M 3/00

US Classification:

4352871, 422 55, 422 56, 422 58, 435 6, 435 72, 435 721, 4352879, 4352884, 4352885, 4352887, 435810, 436164, 436514, 436518, 436524, 436527, 436531, 436533, 436534, 436805, 436806, 436807, 436809

Abstract:

Disclosed are devices for detecting the presence of a preselected analyte in a fluid sample. The devices comprise a substrate microfabricated to define a sample inlet port, and a mesoscale flow system that includes a sample flow channel extending from the inlet port. The mesoscale flow system further includes an analyte detection region in fluid communication with the flow channel comprised of a binding moiety for specifically binding the analyte. The detection region is constructed with a mesoscale dimension sufficiently small to enhance binding of the binding moiety and the analyte. The binding moiety may be immobilized in the detection region. The mesoscale detection systems of the invention may be used in a wide range of applications, including the detection of cells or macromolecules, or for monitoring reactions or cell culture growth.

US Patent:

7771985, Aug 10, 2010

Filed:

Apr 4, 2007

Appl. No.:

11/696365

Inventors:

Peter Wilding - Paoli PA, US
Larry J. Kricka - Berwyn PA, US
Jay N. Zemel - Jenkintown PA, US

Assignee:

Trustees of the University of Pennsylvania - Philadelphia PA

International Classification:

C12M 3/00

US Classification:

4352871, 422 55, 422 57, 422 58, 422 8205, 4352872, 4352884, 4352885, 4352887, 436518, 436514, 436524, 436527, 436805

Abstract:

Disclosed are devices for detecting the presence of a preselected analyte in a fluid sample. The devices comprise a substrate microfabricated to define a sample inlet port, and a mesoscale flow system that includes a sample flow channel extending from the inlet port. The mesoscale flow system further includes an analyte detection region in fluid communication with the flow channel comprised of a binding moiety for specifically binding the analyte. The detection region is constructed with a mesoscale dimension sufficiently small to enhance binding of the binding moiety and the analyte. The binding moiety may be immobilized in the detection region. The mesoscale detection systems of the invention may be used in a wide range of applications, including the detection of cells or macromolecules, or for monitoring reactions or cell culture growth.

US Patent:

8413502, Apr 9, 2013

Filed:

Apr 27, 2009

Appl. No.:

12/920178

Inventors:

Jay N. Zemel - Jenkintown PA, US

Assignee:

Trustees of the University of Pennsylvania - Philadelphia PA

International Classification:

G01F 15/02

US Classification:

73198

Abstract:

Devices, systems and methods for measuring infant feeding performance. The device includes a body portion, a pressure sensor and an integrated circuit. The body portion includes a first end for receiving a fluid, a second end mateable with a feeding nipple, and a conduit in fluid communication with the first and second ends. The pressure sensor is disposed in the body portion, is in contact with the fluid in the conduit, and generates a signal representing a pressure of the fluid passing through the conduit during a feeding session. The integrated circuit is disposed in the body portion and is electrically connected to the pressure sensor. The integrated circuit receives the pressure signal and determines a feeding factor over the feeding session indicative of the infant feeding performance.

US Patent:

8473219, Jun 25, 2013

Filed:

Apr 14, 2008

Appl. No.:

12/595755

Inventors:

Joel Kaplan - Philadelphia PA, US
Jay N. Zemel - Jenkintown PA, US

Assignee:

The Trustees of the University of Pennsylvania - Philadelphia PA

International Classification:

G01N 33/48

US Classification:

702 19

Abstract:

A computational method for generating a feeding score for an individual infant based upon a comparison of feeding factor measurements obtained from the individual infant, values associated with the feeding factor measurements, and feeding parameter metrics from a population of infants having a similar gestational age as the individual infant.

US Patent:

20060223166, Oct 5, 2006

Filed:

Dec 15, 2005

Appl. No.:

11/304119

Inventors:

Peter Wilding - Paoli PA, US
Larry Kricka - Berwyn PA, US
Jay Zemel - Jenkintown PA, US

International Classification:

C12Q 1/68
G01N 33/53
C12M 1/34

US Classification:

435287100, 435006000, 435007100

Abstract:

Disclosed are devices for detecting the presence of a preselected analyte in a fluid sample. The devices comprise a substrate microfabricated to define a sample inlet port, and a mesoscale flow system that includes a sample flow channel extending from the inlet port. The mesoscale flow system further includes an analyte detection region in fluid communication with the flow channel comprised of a binding moiety for specifically binding the analyte. The detection region is constructed with a mesoscale dimension sufficiently small to enhance binding of the binding moiety and the analyte. The binding moiety may be immobilized in the detection region. The mesoscale detection systems of the invention may be used in a wide range of applications, including the detection of cells or macromolecules, or for monitoring reactions or cell culture growth.

US Patent:

20110251510, Oct 13, 2011

Filed:

Mar 29, 2011

Appl. No.:

13/074294

Inventors:

Jay N. Zemel - Jenkintown PA, US

Assignee:

The Trustees Of The University of Pennsylvania - Philadelphia PA

International Classification:

A61B 5/08

US Classification:

600537, 600529

Abstract:

Devices, systems and methods for measuring infant feeding performance. The device includes a body portion, a respiration sensing device for receiving respiration and an integrated circuit disposed in the body portion and electrically connected to the respiration sensing device. The body portion has a first end for receiving a fluid, a second end for passing fluid to a feeding nipple, and a conduit in fluid communication with the first end and the second end. The respiration sensing device is mechanically coupled to the body portion and is mateable with the feeding nipple. The respiration sensing device generates a signal representing a variation in temperature or airflow of the respiration during a feeding session. The integrated circuit receives the temperature or airflow signal determines a respiration pattern over the feeding session indicative of the infant feeding performance.