Jean E Rivier

US Patent:

6515103, Feb 4, 2003

Filed:

May 11, 2000

Appl. No.:

09/142080

Inventors:

Fe C. Abogadie - London, GB
Lourdes J. Cruz - Salt Lake City UT
Baldomero M. Olivera - Salt Lake City UT
Craig Walker - Salt Lake City UT
Clark Colledge - Alpine UT
David R. Hillyard - Salt Lake City UT
Elsie Jimenez - Qyezan, PH
Richard T. Layer - Salt Lake City UT
Li-Ming Zhou - Salt Lake City UT
Gregory S. Shen - Salt Lake City UT
R. Tyler McCabe - Salt Lake City UT
Jean E. Rivier - La Jolla CA

Assignee:

University of Utah Research Foundation - Salt Lake City UT
Cognetix, Inc. - Salt Lake City UT
Salk Institute - LaJolla CA

International Classification:

A61K 3800

US Classification:

530326, 530300, 530327, 514 13, 514 14, 514 15, 514 21

Abstract:

The present invention is directed to conantokin peptides, conantokin peptide derivatives and conantokin peptide chimeras, referred to collectively as conantokins, having 10-30 amino acids, including preferably two or more -carboxyglutamic acid residues. The conantokins are useful for the treatment of neurologic and psychiatric disorders, such as anticonvulsant agents, neuroprotective agents or analgesic agents.

US Patent:

6838274, Jan 4, 2005

Filed:

Jul 31, 2001

Appl. No.:

09/919473

Inventors:

Teresa M. Reyes - Encinitas CA, US
Paul E. Sawchenko - Carlsbad CA, US
Jean E. Rivier - La Jolla CA, US
Kathy A. Lewis - San Diego CA, US
John B. Hogenesch - Encinitas CA, US
Joan M. Vaughan - San Diego CA, US
Marilyn H. Perrin - La Jolla CA, US

Assignee:

Research Development Foundation - Carson City NV

International Classification:

C12N 121
C12N 510
C12N 1512
C12N 1563

US Classification:

4352523, 435 691, 43525411, 435325, 4353201, 43525233, 536 231, 536 235, 536 241

Abstract:

A human urocortin-related peptide with significant sequence homology to the CRF neuropeptide family was identified. A mouse cDNA was isolated from whole brain poly (A+) RNA that encodes a predicted 38 amino acid peptide protein designated herein as urocortin II. Both human URP and mouse Ucn II are structurally related to the other known mammalian family members, CRF and urocortin (Ucn). These peptides are involved in the regulation of the hypothalamic-pituituary-adrenal axis under basal and stress conditions, suggesting a similar role for URP and Ucn II. Synthesized Ucn-II and URP peptide binds with higher affinity to CRF-R2 than to CRF-R1 Ucn II and human URP appear to be involved in the regulation of body temperature and appetite and may play a role in other stress related phenomenon. These findings identify Ucn II and human URP as a new members of the CRF family of neuropeptides, which are expressed centrally and bind to CRF-R2.

US Patent:

6953838, Oct 11, 2005

Filed:

Feb 3, 2004

Appl. No.:

10/771224

Inventors:

Jean E. Rivier - La Jolla CA, US
Koichi S. Kunitake - San Diego CA, US
Kathy A. Lewis - San Diego CA, US
Marilyn H. Perrin - La Jolla CA, US
Jozsef Gulyas - Julian CA, US

Assignee:

Research Development Foundation - Carson City NV

International Classification:

A61K039/00
C07K014/47

US Classification:

530350, 530408, 4241851

Abstract:

A search of the public human genome database identified a human EST, GenBank accession number AW293249, which has high homology to known pufferfish urocortin sequences. The full length sequence was amplified from human genomic DNA and sequenced. Sequence homology comparisons of the novel sequence with human urocortin I and urocortin II revealed that the sequence encoded a novel human urocortin, which was designated urocortin III (UcnIII). While urocortin III does not have high affinity for either CRF-R1 or CRF-R2, the affinity for CRF-R2 is greater than the affinity for CRF-R1. Urocortin III is capable stimulating cyclic AMP production in cells expressing CRF-R2α or β. Thus, the affinity is high enough that urocortin III could act as a native agonist of CRF-R2. However, it is also likely that urocortin III is a stronger agonist of a yet to be identified receptor.

US Patent:

7459427, Dec 2, 2008

Filed:

Aug 29, 2005

Appl. No.:

11/214371

Inventors:

Kathy A. Lewis - San Diego CA, US
Marilyn H. Perrin - La Jolla CA, US
Koichi S. Kunitake - San Diego CA, US
Jean E. Rivier - La Jolla CA, US
Jozsef Gulyas - Julian CA, US

Assignee:

Research Development Foundation - Carson City NV

International Classification:

C07K 14/00

US Classification:

514 2, 530350

Abstract:

A search of the public human genome database identified a human EST, GenBank accession number AW293249, which has high homology to known pufferfish urocortin sequences. The full length sequence was amplified from human genomic DNA and sequenced. Sequence homology comparisons of the novel sequence with human urocortin I and urocortin II revealed that the sequence encoded a novel human urocortin, which was designated urocortin III (UcnIII). While urocortin III does not have high affinity for either CRF-R1 or CRF-R2, the affinity for CRF-R2 is greater than the affinity for CRF-R1. Urocortin III is capable stimulating cyclic AMP production in cells expressing CRF-R2α or β. Thus, the affinity is high enough that urocortin III could act as a native agonist of CRF-R2. However, it is also likely that urocortin III is a stronger agonist of a yet to be identified receptor.

US Patent:

7869958, Jan 11, 2011

Filed:

Aug 9, 2005

Appl. No.:

11/199821

Inventors:

Grace Christy Rani Royappa - La Jolla CA, US
Marilyn H. Perrin - La Jolla CA, US
Jean E. Rivier - La Jolla CA, US
Roland Riek - La Jolla CA, US

Assignee:

Research Development Foundation - Carson City NV

International Classification:

G06G 7/58

US Classification:

702 19, 703 11

Abstract:

The present invention relates to a method for identifying modulators of B1 G-protein coupled receptors. The present invention also relates to a method for identifying an antagonist or agonist of the corticotropin-releasing factor receptor 2 (CRFR2). The present invention also relates to a method for improving antagonists or agonists of CRFR2. The present invention also relates to the three-dimensional structure of CRFR2 as representative of the B1 GPCR subfamily and its use as a basis for rational drug design of antagonist or agonists of B1 GPCRs.

US Patent:

8084413, Dec 27, 2011

Filed:

Nov 6, 2008

Appl. No.:

12/266430

Inventors:

Kathy A. Lewis - San Diego CA, US
Marilyn H. Perrin - La Jolla CA, US
Koichi S. Kunitake - San Diego CA, US
Jean E. Rivier - La Jolla CA, US
Jozsef Gulyas - Julian CA, US

Assignee:

Research Development Foundation - Carson City NV

International Classification:

C07K 14/00

US Classification:

514 1, 530300, 530350

Abstract:

A search of the public human genome database identified a human EST, GenBank accession number AW293249, which has high homology to known pufferfish urocortin sequences. The full length sequence was amplified from human genomic DNA and sequenced. Sequence homology comparisons of the novel sequence with human urocortin I and urocortin II revealed that the sequence encoded a novel human urocortin, which was designated urocortin III (UcnIII). While urocortin III does not have high affinity for either CRF-R1 or CRF-R2, the affinity for CRF-R2 is greater than the affinity for CRF-R1. Urocortin III is capable stimulating cyclic AMP production in cells expressing CRF-R2α or β. Thus, the affinity is high enough that urocortin III could act as a native agonist of CRF-R2. However, it is also likely that urocortin III is a stronger agonist of a yet to be identified receptor.

US Patent:

8445425, May 21, 2013

Filed:

Dec 16, 2011

Appl. No.:

13/328821

Inventors:

Kathy A. Lewis - San Diego CA, US
Marilyn H. Perrin - La Jolla CA, US
Koichi S. Kunitake - San Diego CA, US
Jean E. Rivier - La Jolla CA, US
Jozsef Gulyas - Julian CA, US

Assignee:

Research Development Foundation - Carson City NV

International Classification:

C07K 14/00

US Classification:

514 1, 530300, 530350

Abstract:

A search of the public human genome database identified a human EST, GenBank accession number AW293249, which has high homology to known pufferfish urocortin sequences. The full length sequence was amplified from human genomic DNA and sequenced. Sequence homology comparisons of the novel sequence with human urocortin I and urocortin II revealed that the sequence encoded a novel human urocortin, which was designated urocortin III (UcnIII). While urocortin III does not have high affinity for either CRF-R1 or CRF-R2, the affinity for CRF-R2 is greater than the affinity for CRF-R1. Urocortin III is capable stimulating cyclic AMP production in cells expressing CRF-R2α or β. Thus, the affinity is high enough that urocortin III could act as a native agonist of CRF-R2. However, it is also likely that urocortin III is a stronger agonist of a yet to be identified receptor.

US Patent:

8044025, Oct 25, 2011

Filed:

Dec 7, 2009

Appl. No.:

12/632715

Inventors:

Teresa M. Reyes - Encinitas CA, US
Paul E. Sawchenko - Carlsbad CA, US
Jean E. Rivier - La Jolla CA, US
Kathy A. Lewis - San Diego CA, US
John B. Hogenesch - Encinitas CA, US
Joan M. Vaughan - San Diego CA, US
Marilyn H. Perrin - La Jolla CA, US

Assignee:

Research Development Foundation - Carson City NV

International Classification:

A61K 38/00
A61K 38/28
C07K 16/00

US Classification:

514 108, 514 213, 530300, 530306, 530324

Abstract:

A human urocortin-related peptide with significant sequence homology to the CRF neuropeptide family was identified. A mouse cDNA was isolated from whole brain poly (A+) RNA that encodes a predicted 38 amino acid peptide protein designated herein as urocortin II. Both human URP and mouse Ucn II are structurally related to the other known mammalian family members, CRF and urocortin (Ucn). These peptides are involved in the regulation of the hypothalamic-pituitary-adrenal axis under basal and stress conditions, suggesting a similar role for URP and Ucn IL Synthesized Ucn-II and URP peptide binds with higher affinity to CRF-R2 than to CRF-R1 Ucn II and human URP appear to be involved in the regulation of body temperature and appetite and may play a role in other stress related phenomenon. These findings identify Ucn II and human URP as a new members of the CRF family of neuropeptides, which are expressed centrally and bind to CRF-R2.