Jeannette L Garcia

US Patent:

20200046646, Feb 13, 2020

Filed:

Oct 21, 2019

Appl. No.:

16/658299

Inventors:

- Armonk NY, US
Jeannette M. GARCIA - San Leandro CA, US
James L. HEDRICK - Pleasanton CA, US
Brandon M. KOBILKA - Fishkill NY, US
Jason T. WERTZ - Pleasant Valley NY, US
Rudy J. WOJTECKI - San Jose CA, US

International Classification:

A61K 9/50

Abstract:

Materials and methods for preparing a payload-containing microcapsule with walls that have hexahydrotriazine (HT) and/or hemiaminal (HA) structures are disclosed. To an HT small molecule or a HA small molecule, or a combination thereof, in a solvent is added a cross-linking agent, NHCl, and a copolymer. The solution is acidified, and a payload agent is added. The HT small molecule and HA small molecule may have orthogonal functionality.

US Patent:

20200023069, Jan 23, 2020

Filed:

Sep 20, 2019

Appl. No.:

16/577142

Inventors:

- Armonk NY, US
- Singapore, SG
Jeannette M. Garcia - San Leandro CA, US
James Hedrick - Pleasanton CA, US
Nathaniel H. Park - San Jose CA, US
Rudy J. Wojtecki - San Jose CA, US
Chuan Yang - Hillington Green, SG
YiYan Yang - Singapore, SG

International Classification:

A61K 47/60
C08G 65/332
C08G 65/00
C08L 71/02
C08G 64/18
C08L 71/00
A61K 9/107
A61K 47/69
A61K 31/785
A61P 35/00

Abstract:

Embodiments of the invention are directed to a macromolecular chemotherapeutic. A non-limiting example of the macromolecular chemotherapeutic includes a block copolymer. The block copolymer can include a water-soluble block, a cationic block, and a linker, wherein the linker is connected to the water-soluble bock and the charged block.

US Patent:

20200011797, Jan 9, 2020

Filed:

Jul 18, 2019

Appl. No.:

16/515968

Inventors:

- Armonk NY, US
Jeannette M. Garcia - San Leandro CA, US
Ricardo L. Ohta - Sao Paulo, BR
Ademir F. Silva - Sao Paulo, BR
Mathias B. Steiner - Rio de Janeiro, BR
Jaione Tirapu Azpiroz - Rio de Janeiro, BR
Thomas G. Zimmerman - Cupertino CA, US

International Classification:

G01N 21/64

Abstract:

A system is provided for performing metal trace analysis on a liquid sample. A sample holder holds an analysis substrate that includes a reference region and at least one test region. An ultraviolet (UV) light source emits ultraviolet light illuminating the liquid sample. An optical sensor detects radiation emanating from the liquid sample and converting the detected radiation into an electrical signal. A microcontroller processes the electrical signal. An external interface transmits the processed electrical signal to an external device. The analysis substrate is configured for manual movement by a user. A tracking system detects a sample scanning location for the metal trace analysis, and includes a light source, other than the UV light source, and another optical sensor. The other optical sensor detects light emitted by the light source.

US Patent:

20190307684, Oct 10, 2019

Filed:

Jun 25, 2019

Appl. No.:

16/451489

Inventors:

- Armonk NY, US
- Matrix, SG
Mareva B. Fevre - San Jose CA, US
Jeannette Garcia - San Leandro CA, US
James L. Hedrick - Pleasanton CA, US
Eunice Leong - Singapore, SG
Nathaniel H. Park - San Jose CA, US
Rudy J. Wojtecki - San Jose CA, US
Yi Yan Yang - Singapore, SG

International Classification:

A61K 9/107
A61K 47/69
C08G 64/02
A61K 47/60
A61K 31/704
C08G 64/18
C08G 81/00

Abstract:

The subject matter of this invention relates to block copolymers (BCPs) and, more particularly, to block copolymers capable of self-assembly into nanoparticles for the delivery of hydrophobic cargos. The BCPs include a hydrophobic block that contains a thioether functional group that is susceptible to oxidation, transforming the solubility of the block from hydrophobic to hydrophilic, thereby releasing the hydrophobic cargo of the nanoparticle.

US Patent:

20190218342, Jul 18, 2019

Filed:

Mar 22, 2019

Appl. No.:

16/362275

Inventors:

- Armonk NY, US
Jeannette M. Garcia - San Leandro CA, US
James L. Hedrick - Pleasanton CA, US
Jason T. Wertz - Pleasant Valley NY, US
Rudy J. Wojtecki - San Jose CA, US

International Classification:

C08G 73/06
G03F 7/038
C08G 12/08
G03F 7/20
G03F 7/30

Abstract:

This disclosure describes new compositions and methods related to photoresponsive poly(hexahydrotriazines) and related polymers. In an embodiment, a method of patterning a substrate includes forming a liquid poly(hemiaminal) material by a process that includes forming a reaction mixture comprising a polar solvent, paraformaldehyde, and an aminobenzene compound having photoreactive groups, and heating the reaction mixture at a temperature up to 50 C. The method further includes applying the liquid poly(hemiaminal) material to a substrate; patterning the liquid poly(hemiaminal) material with UV light; and curing the liquid poly(hemiaminal) material to form a cured poly(hexahydrotriazine) polymer.

US Patent:

20190211152, Jul 11, 2019

Filed:

Mar 15, 2019

Appl. No.:

16/355075

Inventors:

- Armonk NY, US
Jeannette M. GARCIA - San Leandro CA, US
James L. HEDRICK - Pleasanton CA, US
Rudy J. WOJTECKI - San Jose CA, US

International Classification:

C08G 73/06
C08J 9/00
C08J 9/26
C08K 7/06

Abstract:

In an embodiment, a polymeric material includes a plurality of hemiaminal units bonded together by a first linkage and a second linkage, wherein the first linkage is thermally stable and resistant to bases and the second linkage is thermally degradable and degradable by a base. In another embodiment, a method of forming nanoporous materials includes forming a polymer network with a chemically removable portion. The chemically removable portion may be polycarbonate polymer that is removable on application of heat or exposure to a base, or a polyhexahydrotriazine (PHT) or polyhemiaminal (PHA) polymer that is removable on exposure to an acid. Removing any portion of the polymer results in formation of nanoscopic pores as polymer chains are decomposed, leaving pores in the polymer matrix.

US Patent:

20190177481, Jun 13, 2019

Filed:

Feb 13, 2019

Appl. No.:

16/274809

Inventors:

- Armonk NY, US
Mareva FEVRE - San Jose CA, US
Jeannette M. GARCIA - San Leandro CA, US
James L. HEDRICK - Pleasanton CA, US
Rudy J. WOJTECKI - San Jose CA, US

International Classification:

C08G 73/06
C08C 19/22
C09D 179/04
C09D 161/22
C08G 16/02
C08G 12/08
C08G 73/02

Abstract:

Polyhemiaminal (PHA) and polyhexahydrotriazine (PHT) materials are modified by 1,4 conjugate addition chemical reactions to produce a variety of molecular architectures comprising pendant groups and bridging segments. The materials are formed by a method that includes heating a mixture comprising solvent(s), paraformaldehyde, aromatic amine groups, aliphatic amine Michael donors, and Michael acceptors, such as acrylates. The reaction mixtures may be used to prepare polymer pre-impregnated materials and composites containing PHT matrix resin.

US Patent:

20190167584, Jun 6, 2019

Filed:

Dec 5, 2017

Appl. No.:

15/832157

Inventors:

- Armonk NY, US
Willy Chin - Singapore, SG
Mareva B. Fevre - San Jose CA, US
Jeannette Garcia - San Leandro CA, US
James L. Hedrick - Pleasanton CA, US
Eunice Leong - Singapore, SG
Nathaniel H. Park - San Jose CA, US
Rudy J. Wojtecki - San Jose CA, US
Yi Yan Yang - Singapore, SG

International Classification:

A61K 9/107
A61K 47/69
A61K 47/60
C08G 64/18
C08G 64/02
C08G 81/00

Abstract:

The subject matter of this invention relates to block copolymers (BCPs) and, more particularly, to block copolymers capable of self-assembly into nanoparticles for the delivery of hydrophobic cargos. The BCPs include a hydrophobic block that contains a thioether functional group that is susceptible to oxidation, transforming the solubility of the block from hydrophobic to hydrophilic, thereby releasing the hydrophobic cargo of the nanoparticle.