Jeffery Press from Tarrytown, NY

Chemically Modified Saponins And The Use Thereof As Adjuvants
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US Patent:

62620290, Jul 17, 2001
Filed:

Aug 13, 1999
Appl. No.:

9/373660
Inventors:

Jeffery B. Press - Brewster NY
Dante J. Marciani - Birmingham AL
Assignee:

Galenica Pharmaceuticals, Inc. - Frederick MD
International Classification:

A61K 3170
A61K 3900
C07H 1524
US Classification:

514 26
Abstract:

The present invention is directed to novel bidesmosidic saponin derivatives comprising a triterpene aglycone core substituted at positions 3 and 28 with a monosaccharide or an oligosaccharide which can be the same or different, and having an aldehyde group attached to the core, preferably at the 4-position. The novel derivatives include a lipophilic group that is covalently attached to the 4-position of a fucosyl group that is required in the 28-oligosaccharide substituent. These derivatives preferably have Formula I: ##STR1## wherein Z and R. sup. 1 to R. sup. 3 are defined herein. The present invention is also directed to pharmaceutical and veterinary compositions comprising one or more compounds of the present invention. These compositions may be employed as immunopotentiators in animals and humans. The present invention is also directed to methods of making these compounds and to methods of using these compounds as immunostimulating agents and as adjuvants.

N-[(1H-1,2,4-Triazol-1-Yl)Alkyl]-Arylamides
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US Patent:

45686858, Feb 4, 1986
Filed:

Feb 29, 1984
Appl. No.:

6/584702
Inventors:

William B. Wright - Woodcliff Lake NJ
Jeffery B. Press - Tuxedo NY
Andrew S. Tomcufcik - Old Tappan NJ
Assignee:

American Cyanamid Company - Stamford CT
International Classification:

A61K 3141
C07D24908
C07D40306
US Classification:

514383
Abstract:

N-[(1H-1,2,4-Triazol-l-yl)alkyl]arylamides which are inhibitors of thromboxane synthetase enzyme.

Novel 4-(Substituted-Aminophenoxy)-3-Thiophenemethanols
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US Patent:

42398983, Dec 16, 1980
Filed:

Feb 11, 1980
Appl. No.:

6/120198
Inventors:

Jeffery B. Press - Tuxedo NY
Assignee:

American Cyanamid Company - Stamford CT
International Classification:

C07D33316
A01K 3138
US Classification:

549 65
Abstract:

This disclosure describes novel 4-(substituted-aminophenoxy)-3-thiophenemethanols which are useful as anti-depressant agents.

Substituted N-[(1H-1,2,4-Triazol-1-Yl)-Alkyl]Heteroarylcarboxamides
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US Patent:

45421455, Sep 17, 1985
Filed:

Feb 29, 1984
Appl. No.:

6/584701
Inventors:

William B. Wright - Woodcliff Lake NJ
Jeffery B. Press - Tuxedo NY
Andrew S. Tomcufcik - Old Tappan NJ
Assignee:

American Cyanamid Company - Stamford CT
International Classification:

A61K 3141
C07D40512
C07D40912
US Classification:

514383
Abstract:

Substituted N-[(1H-1,2,4-triazol-1-yl)-alkyl]heteroarylcarboxamides are inhibitors of thromboxane synthetase enzyme.

N-(Substituted Phenyl)-N'-[(1H-Imidazol-1-Yl) And (1H-1,2,4-Triazol-1-Yl)Alkyl]Ureas
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US Patent:

45769575, Mar 18, 1986
Filed:

Jul 5, 1984
Appl. No.:

6/628095
Inventors:

Joseph W. Marsico - Pearl River NY
William B. Wright - Woodcliff Lake NJ
Jeffery B. Press - Tuxedo NY
Assignee:

American Cyanamid Company - Stamford CT
International Classification:

A61K 3141
A61K 31415
C07D23361
C07D24908
US Classification:

514383
Abstract:

N-(Substituted phenyl)-N'-[(1H-imidazol-1-yl) and (1H-1,2,4-triazol-1-yl)alkyl]ureas which are inhibitors of thromboxane synthetase enzyme.

Modified Amino Acids And Compositions Comprising The Same For Delivering Active Agents
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US Patent:

60715103, Jun 6, 2000
Filed:

Apr 23, 1997
Appl. No.:

8/839094
Inventors:

Jeffery Bruce Press - Brewster NY
Nai-Fang Wang - Long Island NY
Assignee:

Emisphere Technologies, Inc. - Tarrytown NY
International Classification:

A61K 3170
A61K 3817
A61K 4712
C07C22906
US Classification:

424 852
Abstract:

The present invention provides modified amino acids for delivering active agents, and particularly biologically or chemically active agents. The preferred modified amino acids of the present invention include N-acylated or sulfonated amino acids. These modified amino acids are used as carriers to facilitate the delivery of a cargo to a target. Such modified amino acids are well suited to form non-covalent mixtures with biologically-active agents for oral administration to animals. Methods for the preparation and administration of the modified amino acids and compositions including the same are also provided.

N-[(1H-Imidazol-1-Yl)Alkyl]-1H-Indolecarboxamides Useful As Thromboxane Synthetase Inhibitors And Antihypertensive Agents
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US Patent:

46199411, Oct 28, 1986
Filed:

Nov 19, 1984
Appl. No.:

6/673066
Inventors:

William B. Wright - Woodcliff Lake NJ
Jeffery B. Press - Rocky Hill NJ
Assignee:

American Cyanamid Company - Stamford CT
International Classification:

A61K 31415
C07D40312
US Classification:

514397
Abstract:

This invention discloses novel N-[(1H-imidazol-1-yl)alkyl]-1H-indolecarboxamides which are useful as inhibitors of thromboxane synthetase and/or as antihypertensive agents in the treatment of hypertension and myocardial ischemia.

Thromboxane Synthetase Enzyme Inhibiting N-[(1H-Imidazol-1-Yl) And (1H-1,2,4-Triazol-1-Yl)Alkyl]Pyridinecarboxamides
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US Patent:

45555192, Nov 26, 1985
Filed:

Nov 19, 1984
Appl. No.:

6/673069
Inventors:

William B. Wright - Woodcliff Lake NJ
Jeffery B. Press - Rocky Hill NJ
Assignee:

American Cyanamid Company - Stamford CT
International Classification:

C07D40112
A61K 31455
US Classification:

514340
Abstract:

This invention concerns novel N-[(1H-imidazol-1-yl) and (1H-1,2,4-triazol-1-yl)alkyl]pyridinecarboxamides which are useful as inhibitors of thromboxane synthetase and/or as hypotensive agents in the treatment of hypertension and myocardial ischemia.