Jeffery B Press

US Patent:

47075503, Nov 17, 1987

Filed:

Jan 21, 1987

Appl. No.:

7/005545

Inventors:

Jeffery B. Press - Rocky Hill NJ
Ronald K. Russell - Pennington NJ

Assignee:

Ortho Pharmaceutical Corporation - Raritan NJ

International Classification:

C07D40912

US Classification:

544379

Abstract:

The synthesis of thienopyrimidine-2,4-dione derivatives and their urea intermediates is described. The novel urea intermediates and thienopyrimidine-2,4-dione derivatives are general vasodilating agents and anti-hypertensive agents. The compounds are useful as cardiovascular agents.

US Patent:

48717452, Oct 3, 1989

Filed:

Oct 17, 1988

Appl. No.:

7/258346

Inventors:

Jeffery B. Press - Rocky Hill NJ

Assignee:

Ortho Pharmaceutical Corporation - Raritan NJ

International Classification:

A61K 31395
A61K 3140

US Classification:

514300

Abstract:

Novel 2- or 3- aryl substituted imidazo[1,2-a]pyridines and their synthesis are described. The compounds have local anesthetic properties and are useful as local anesthetic agents, calcium channel blocking agents and antisecretory agents.

US Patent:

62620290, Jul 17, 2001

Filed:

Aug 13, 1999

Appl. No.:

9/373660

Inventors:

Jeffery B. Press - Brewster NY
Dante J. Marciani - Birmingham AL

Assignee:

Galenica Pharmaceuticals, Inc. - Frederick MD

International Classification:

A61K 3170
A61K 3900
C07H 1524

US Classification:

514 26

Abstract:

The present invention is directed to novel bidesmosidic saponin derivatives comprising a triterpene aglycone core substituted at positions 3 and 28 with a monosaccharide or an oligosaccharide which can be the same or different, and having an aldehyde group attached to the core, preferably at the 4-position. The novel derivatives include a lipophilic group that is covalently attached to the 4-position of a fucosyl group that is required in the 28-oligosaccharide substituent. These derivatives preferably have Formula I: ##STR1## wherein Z and R. sup. 1 to R. sup. 3 are defined herein. The present invention is also directed to pharmaceutical and veterinary compositions comprising one or more compounds of the present invention. These compositions may be employed as immunopotentiators in animals and humans. The present invention is also directed to methods of making these compounds and to methods of using these compounds as immunostimulating agents and as adjuvants.

US Patent:

50011278, Mar 19, 1991

Filed:

Nov 22, 1989

Appl. No.:

7/440952

Inventors:

Jeffery B. Press - Rocky Hill NJ
Zoltan G. Hajos - Princeton NJ

Assignee:

Ortho Pharmaceutical Corporation - Raritan NJ

International Classification:

C07D48704
A61K 31415

US Classification:

514258

Abstract:

4-Substituted pyrazolo[3,4-d]pyrimidine derivatives and a method of synthesis for the derivatives are described. The 4-substituted pyrazolopyrimidine derivatives are useful as cardiotonic agents and antiarrhythmic agents.

US Patent:

47912006, Dec 13, 1988

Filed:

Jun 22, 1987

Appl. No.:

7/064717

Inventors:

Jeffery B. Press - Rocky Hill NJ
Pauline Sanfilippo - Flemington NJ
Maud Urbanski - Belle Mead NJ

Assignee:

Ortho Pharmaceutical Corporation - Raritan NJ

International Classification:

C07D27728
C07D41712
A61K 31425

US Classification:

544369

Abstract:

The present invention relates to novel 2-substituted-4-aryloxyalkylamine thiazoles as described herein. The thiazoles are useful as antisecretory agents.

US Patent:

41442350, Mar 13, 1979

Filed:

Mar 13, 1978

Appl. No.:

5/886234

Inventors:

Jeffery B. Press - Bellvale NY
Sidney R. Safir - River Edge NJ

Assignee:

American Cyanamid Company - Stamford CT

International Classification:

C07D51304
C07D49504
C07D49804

US Classification:

2602393T

Abstract:

This disclosure describes novel substituted thieno[3,4-b][1,5]benzoxazepin-10 (9H)-ones and thieno[3,4-b][1,5]benzothiazepin-10(9H)-ones which are useful as intermediates for the preparation of 10-[4-(substituted)-1-piperazinyl]thieno[3,4-b][1,5]benzoxazepines and 10-[4-(substituted)-1-piperazinyl]thieno[3,4-b][1,5]benzothiazepines which possess anti-psychotic or neuroleptic activity.

US Patent:

52848574, Feb 8, 1994

Filed:

Dec 21, 1990

Appl. No.:

7/631593

Inventors:

Jeffery B. Press - Penllyn PA
Pauline Sanfilippo - Flemington NJ
James J. McNally - High Bridge NJ
Robert Falotico - Belle Mead NJ

Assignee:

Ortho Pharmaceutical Corporation - Raritan NJ

International Classification:

A61K 3138
C07D49704

US Classification:

514321

Abstract:

Substituted thienopyrans and processes for preparing the thienopyrans are disclosed. The thienopyrans are useful as antihypertensive agents; antianginals are peripheral antivasoconstrictive agents.

US Patent:

48351571, May 30, 1989

Filed:

Mar 15, 1988

Appl. No.:

7/168199

Inventors:

Jeffery B. Press - Rocky Hill NJ
Ronald K. Russell - Titusville NJ

Assignee:

Ortho Pharmaceutical Corporation - Raritan NJ

International Classification:

C07D49100
A61K 31505

US Classification:

514258

Abstract:

Novel thienopyrimidine-2,4-dione piperidine derivatives and novel furo[3,4-d]pyrimidine-2,4-dione piperidine derivatives are described. The novel piperidine derivatives are selective serotonin antagonists and alpha adrenergic blocking agents with cardiovascular, gastrointestinal and central nervous system activites.