Jeffrey E Abbott

US Patent:

20230014082, Jan 19, 2023

Filed:

Sep 8, 2022

Appl. No.:

17/940174

Inventors:

- Cambridge MA, US
Jeffrey T. Abbott - Cambridge MA, US
Wenxuan Wu - Cambridge MA, US
Tianyang Ye - Cambridge MA, US
Han Sae Jung - Cambridge MA, US
Donhee Ham - Cambridge MA, US

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

G01N 27/327

Abstract:

Disclosed herein are an apparatus for electrically assessing and/or manipulating cells. One aspect is directed to electrically mapping cells on the surface of the semiconductor substrate via cross-electrode impedance measurements. Further according to some aspects, the electrode array allows for spatially addressable electrical stimulation and/or recording of electrical signals in real-time using the CMOS circuitry. Some of these aspects are directed to using an electrode array to perform cell patterning through electrochemical gas generation, and extracellular electrochemical mapping.

US Patent:

20200292482, Sep 17, 2020

Filed:

Oct 30, 2018

Appl. No.:

16/760723

Inventors:

- Cambridge MA, US
Hongkun Park - Cambridge MA, US
Keith Krenek - Cambridge MA, US
Tianyang Ye - Cambridge MA, US
Jeffrey T. Abbott - Cambridge MA, US
Wenxuan Wu - Cambridge MA, US

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

G01N 27/327
C12M 1/34
C12N 13/00
G01N 27/416

Abstract:

Methods and systems for monitoring the activity of electrogenic networks are described. One representative system includes an array of electrode coupled to an analyzer having a stimulator and a receiver. The electrode is placed in contact with an electrogenic cell. The electrodes can be shaped as nanowires, tubes, cavities and/or cones. The analyzer may be configured to operate in a voltage stimulation mode, in which the cells are stimulated via voltages and monitored via current, or in a current stimulation mode, in which the cells are stimulated via currents and monitored via voltages. The analyzers may be arranged as single-stage amplifiers, and may include a feedback loop shared between the stimulation signal path and the sensing signal path. The feedback loop may be arranged to provide overlapping stimulation and sensing of the electrogenic network's cells.