Jeffrey A Abbott

US Patent:

20230014082, Jan 19, 2023

Filed:

Sep 8, 2022

Appl. No.:

17/940174

Inventors:

- Cambridge MA, US
Jeffrey T. Abbott - Cambridge MA, US
Wenxuan Wu - Cambridge MA, US
Tianyang Ye - Cambridge MA, US
Han Sae Jung - Cambridge MA, US
Donhee Ham - Cambridge MA, US

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

G01N 27/327

Abstract:

Disclosed herein are an apparatus for electrically assessing and/or manipulating cells. One aspect is directed to electrically mapping cells on the surface of the semiconductor substrate via cross-electrode impedance measurements. Further according to some aspects, the electrode array allows for spatially addressable electrical stimulation and/or recording of electrical signals in real-time using the CMOS circuitry. Some of these aspects are directed to using an electrode array to perform cell patterning through electrochemical gas generation, and extracellular electrochemical mapping.

US Patent:

20210371846, Dec 2, 2021

Filed:

Jul 6, 2018

Appl. No.:

16/625603

Inventors:

- Cambridge MA, US
Jeffrey T ABBOTT - Watertown MA, US
Hongkun PARK - Lexington MA, US
Wenxuan WU - Waltham MA, US

Assignee:

PRESIDENT AND FELLOWS OF HARVARD COLLEGE - Cambridge MA

International Classification:

C12N 13/00
C12M 1/42
G01N 27/00

Abstract:

Methods and systems for stimulating and monitoring electrogenic cells are described. Some systems for stimulating electrogenic cells are based on the injection of electric currents into the cells via electrodes connected to the cells. Such stimulators may comprise an impedance element having an input terminal and an output terminal coupled to an electrode, and a voltage follower coupled between the input terminal and the output terminal of the impedance element, the voltage follower being configured to maintain a substantially constant voltage between the input terminal and the output terminal of the impedance element. The impedance element may comprise one or more switched capacitors at least in some embodiments. In some embodiments, the voltage follower may be implemented using a source follower.

US Patent:

20200292482, Sep 17, 2020

Filed:

Oct 30, 2018

Appl. No.:

16/760723

Inventors:

- Cambridge MA, US
Hongkun Park - Cambridge MA, US
Keith Krenek - Cambridge MA, US
Tianyang Ye - Cambridge MA, US
Jeffrey T. Abbott - Cambridge MA, US
Wenxuan Wu - Cambridge MA, US

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

G01N 27/327
C12M 1/34
C12N 13/00
G01N 27/416

Abstract:

Methods and systems for monitoring the activity of electrogenic networks are described. One representative system includes an array of electrode coupled to an analyzer having a stimulator and a receiver. The electrode is placed in contact with an electrogenic cell. The electrodes can be shaped as nanowires, tubes, cavities and/or cones. The analyzer may be configured to operate in a voltage stimulation mode, in which the cells are stimulated via voltages and monitored via current, or in a current stimulation mode, in which the cells are stimulated via currents and monitored via voltages. The analyzers may be arranged as single-stage amplifiers, and may include a feedback loop shared between the stimulation signal path and the sensing signal path. The feedback loop may be arranged to provide overlapping stimulation and sensing of the electrogenic network's cells.