Jeffrey P Porter

US Patent:

6432970, Aug 13, 2002

Filed:

Jun 4, 1998

Appl. No.:

09/090622

Inventors:

Philip A. Beachy - Baltimore MD
Michael K. Cooper - Baltimore MD
Jeffrey A. Porter - Belmont MA

Assignee:

Johns Hopkins University School of Medicine - Baltimore MD

International Classification:

A61K 3144

US Classification:

514278

Abstract:

The present invention makes availables assays and reagents inhibiting paracrine and/or autocrine signals produced by a hedgehog protein comprising contacting a cell sensitive to the hedgehog protein with a steroidal alkaloid, or other small molecule, in a sufficient amount to reduce the sensitivity of the cell to the hedgehog protein.

US Patent:

6867216, Mar 15, 2005

Filed:

Nov 8, 2000

Appl. No.:

09/708974

Inventors:

Philip A. Beachy - Ruxton MD, US
Michael K. Cooper - Baltimore MD, US
Jeffrey A. Porter - Belmont MA, US

Assignee:

Johns Hopkins University School of Medicine - Baltimore MD

International Classification:

A61K031/44

US Classification:

514278

Abstract:

The present invention makes availables assays and reagents inhibiting paracrine and/or autocrine signals produced by a hedgehog protein or aberrant activation of a hedgehog signal transduction pathway, e. g. , which involve the use of a steroidal alkaloid or other small molecule.

US Patent:

6911528, Jun 28, 2005

Filed:

May 2, 2000

Appl. No.:

09/562914

Inventors:

Philip A. Beachy - Baltimore MD, US
Jeffrey A. Porter - Belmont MA, US

Assignee:

The Johns Hopkins University School of Medicine - Baltimore MD

International Classification:

C07K014/475

US Classification:

530350, 536 235, 530300

Abstract:

The present invention provides two novel polypeptides, referred to as the “N” and “C” fragments of hedgehog, or N-terminal and C-terminal fragments, respectively, which are derived after specific cleavage at a G↓CF site recognized by the autoproteolytic domain in the native protein. Also included are sterol-modified hedgehog polypeptides and functional fragments thereof. Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol modification of hedgehog protein are described.

US Patent:

7220838, May 22, 2007

Filed:

Jun 11, 2003

Appl. No.:

10/460594

Inventors:

Philip A. Beachy - Baltimore MD, US
Jeffrey A. Porter - Belmont MA, US

Assignee:

The Johns Hopkins University School of Medicine - Baltimore MD

International Classification:

C07K 16/00
C07K 16/18

US Classification:

5303881, 530350, 5303871, 5303891, 53038885, 436547, 436548, 435326

Abstract:

The present invention provides two novel polypeptides, referred to as the “N” and “C” fragments of hedgehog, or N-terminal and C-terminal fragments, respectively, which are derived after specific cleavage at a GCF site recognized by the autoproteolytic domain in the native protein. Also included are sterol-modified hedgehog polypeptides and functional fragments thereof. Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol modification of hedgehog protein are described.

US Patent:

7291626, Nov 6, 2007

Filed:

Nov 8, 2000

Appl. No.:

09/708964

Inventors:

Philip A. Beachy - Ruxton MD, US
Michael K. Cooper - Baltimore MD, US
Jeffrey A. Porter - Belmont MA, US

Assignee:

John Hopkins University School of Medicine - Baltimore MD

International Classification:

A61K 31/4355

US Classification:

514278

Abstract:

The present invention makes availables assays and reagents inhibiting paracrine and/or autocrine signals produced by a hedgehog protein or aberrant activation of a hedgehog signal transduction pathway, e. g. , which involve the use of a steroidal alkaloid or other small molecule.

US Patent:

7741451, Jun 22, 2010

Filed:

May 18, 2007

Appl. No.:

11/804733

Inventors:

Philip A. Beachy - Baltimore MD, US
Jeffrey A. Porter - Belmont MA, US

Assignee:

The Johns Hopkins University School of Medicine - Baltimore MD

International Classification:

C07K 16/00
C07K 16/18

US Classification:

5303892, 5303891, 5303881, 53038824, 4241841

Abstract:

The present invention provides two novel polypeptides, referred to as the “N” and “C” fragments of hedgehog, or N-terminal and C-terminal fragments, respectively, which are derived after specific cleavage at a G′CF site recognized by the autoproteolytic domain in the native protein. Also included are sterol-modified hedgehog polypeptides and functional fragments thereof. Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol modification of hedgehog protein are described.

US Patent:

8076073, Dec 13, 2011

Filed:

May 20, 2003

Appl. No.:

10/442435

Inventors:

Philip A. Beachy - Baltimore MD, US
Jeffrey A. Porter - Belmont MA, US
Michael K. Cooper - Baltimore MD, US

Assignee:

The Johns Hopkins University School of Medicine - Baltimore MD

International Classification:

C12Q 1/00
C12Q 1/68

US Classification:

435 61, 435 4, 435 613, 435 617

Abstract:

The present invention sterol-modified hedgehog polypeptides and functional fragments thereof. Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol modification of hedgehog protein are described. In one aspect of the invention, the method provides a means for affecting cholesterol biosynthesis or transport in a cell comprising contacting a cell with an effective amount of a compound that affects hedgehog, thereby affecting cholesterol biosynthesis or transport. The effect may be inhibition or stimulation of cholesterol biosynthesis or transport.

US Patent:

8103546, Jan 24, 2012

Filed:

Dec 29, 2004

Appl. No.:

11/023638

Inventors:

G. Thomas Des Jardins - Alexandria VA, US
Jeffrey Dalton Porter - Flower Mound TX, US
David Markley - Gainesville VA, US
Bryan Slavin - Rockville MD, US

Assignee:

Lightningcast LLC - Baltimore MD

International Classification:

G06Q 30/00
H04N 7/10
G11C 7/00

US Classification:

705 1473, 705 1452, 725 9, 725 35, 725116, 365200

Abstract:

Programming media and advertising media may be presented in a manner that approximates or equals a target ratio. In one implementation, a total temporal length of one or more programming media segments is accessed after the user has selected the programming media segments. One or more advertising media segments are then selected. The advertising media segments have a total length that is based on the total temporal length of the programming media segments and a target temporal ratio between programming media and advertising media. The client system may present the one or more selected advertising media segments.