Jeffrey R Preiss

US Patent:

20090053138, Feb 26, 2009

Filed:

Nov 2, 2005

Appl. No.:

11/666954

Inventors:

Jeffrey Preiss - Cambridge MA, US
Charles Wilson - Concord MA, US
Martin Stanton - Concord MA, US
John Diener - Cambridge MA, US
David Epstein - Huntington NY, US
Dilara McCauley - Cambridge MA, US
Thomas McCauley - Cambridge MA, US

International Classification:

A61K 49/00
C07H 21/04
A61P 35/00
A61K 31/711

US Classification:

424009100, 536023100, 514044000

Abstract:

Materials and methods are provided for producing and using aptamers as oncology therapeutics capable of binding to PDGF, PDGF isoforms, PDGF receptor, VEGF, and/or VEGF receptor or any combination thereof with affinity and specificity. The compositions of the present invention are particularly useful in solid tumor therapy and can be used alone or in combination with known cytotoxic agents for the treatment of solid tumors. Also disclosed are aptamers having one or more CpG motifs embedded therein or appended thereto.

US Patent:

20050124565, Jun 9, 2005

Filed:

Jun 21, 2004

Appl. No.:

10/873853

Inventors:

John Diener - Cambridge MA, US
David Epstein - Belmont MA, US
Alicia Ferguson - Somerville MA, US
Dilara Grate - Waltham MA, US
Anthony Keefe - Cambridge MA, US
Thomas McCauley - Cambridge MA, US
Jeffrey Preiss - Somerville MA, US
Martin Stanton - Concord MA, US
Charles Wilson - Concord MA, US

International Classification:

A61K048/00
C07H021/04
C12N015/85

US Classification:

514044000, 435455000, 536023200

Abstract:

Materials and methods are provided for producing and using aptamers useful as oncology therapeutics capable of binding to PDGF, PDGF isoforms, PDGF receptor, VEGF, and VEGF receptor or any combination thereof with great affinity and specificity. The compositions of the present invention are particularly useful in solid tumor therapy and can be used alone or in combination with known cytotoxic agents for the treatment of solid tumors. Also disclosed are aptamers having one or more CpG motifs embedded therein or appended thereto.