Jeffrey S Randall

US Patent:

7282330, Oct 16, 2007

Filed:

Feb 5, 2004

Appl. No.:

10/773084

Inventors:

Xiaojian (David) Zhao - Westford MA, US
Jeffrey D. Randall - Canton MA, US
Bijit Kundu - Brookline MA, US
Jessica Kesty - Seabrook NH, US
Steven R. Gullans - Natick MA, US
Eugene Y. Chan - Boston MA, US
Martin Fuchs - Uxbridge MA, US
Jenny E. Rooke - Somerville MA, US

Assignee:

U.S. Genomics, Inc. - Woburn MA

International Classification:

C12Q 1/68
C07H 21/02
C07H 21/04

US Classification:

435 6, 536 231, 536 243

Abstract:

The invention relates to methods for analyzing and characterizing single polymers such as nucleic acid molecules. In preferred embodiments, the single molecules are analyzed using single molecule detection and analysis systems.

US Patent:

7371520, May 13, 2008

Filed:

May 28, 2003

Appl. No.:

10/448264

Inventors:

Xiaojian (David) Zhao - Westford MA, US
Jeffrey D. Randall - Canton MA, US
Bijit Kundu - Brookline MA, US
Jessica Kesty - Seabrook NH, US
Steve R. Gullans - Natick MA, US
Eugene Y. Chan - Brookline MA, US
Martin Fuchs - Uxbridge MA, US

Assignee:

U.S. Genomics, Inc. - Woburn MA

International Classification:

C12Q 1/68
C07H 21/02
C07H 21/04

US Classification:

435 6, 536 231, 536 243

Abstract:

The invention relates to methods for analyzing and characterizing single polymers such as nucleic acid molecules. In preferred embodiments, the single molecules are analyzed using single molecule detection and analysis systems.

US Patent:

8222047, Jul 17, 2012

Filed:

Sep 23, 2008

Appl. No.:

12/236486

Inventors:

David C. Duffy - Somerville MA, US
Evan Ferrell - Brighton MA, US
Jeffrey D. Randall - Canton MA, US
David M. Rissin - Medford MA, US
David R. Walt - Boston MA, US

Assignee:

Quanterix Corporation - Lexington MA

International Classification:

G01N 33/543

US Classification:

436518

Abstract:

The present invention relates to systems and methods for detecting analyte molecules or particles in a fluid sample and in some cases, determining a measure of the concentration of the molecules or particles in the fluid sample. Methods of the present invention may comprise immobilizing a plurality of analyte molecules or particles to form a plurality of complexes, releasing at least a portion of some of the plurality of complexes, determining at least a portion of the plurality of complexes released, and determining a measure of the concentration of the analyte molecules or particles in a fluid sample.

US Patent:

57732132, Jun 30, 1998

Filed:

Jun 6, 1994

Appl. No.:

8/254811

Inventors:

Steven R. Gullans - Natick MA
Ryoji Kojima - Boston MA
Jeffrey Randall - Acton MA

Assignee:

Brigham & Women's Hospital - Boston MA

International Classification:

C07H 2102
C07H 2104
C12P 1934
C12Q 168

US Classification:

435 6

Abstract:

A method for conducting sequential nucleic acid hybridization steps is described, whereby the ability of earlier-used primers or probes to participate in subsequent hybridization steps can be minimized, even though the differences between primer lengths are relatively small. It also relates to a rapid and quantitative method for the sequential synthesis of polynucleotide sequences by using a plurality of oligonucleotide primers, with the earlier utilized primers causing a minimum of interference with the subsequent primed synthesis reactions, yet without the need for intermediate purification steps. One preferred embodiment described is a method for differential display reverse-transcription polymerase chain reaction (DDRT-PCR), wherein complementary DNAs (cDNAs) are first synthesized using oligo-dT-primed reverse transcription (RT), and selected subsets of said cDNAs are then amplified using a second primer in a polymerase chain reaction (PCR), with a minimum degree of background being caused in the PCR step by residual amounts of the oligo-dT primer.

US Patent:

20220244276, Aug 4, 2022

Filed:

Feb 18, 2022

Appl. No.:

17/674968

Inventors:

- Billerica MA, US
John Henrik Zetterberg - Molnlycke, SE
Kaj Blennow - Kungsbacka, SE
Jeffrey D. Randall - Canton MA, US

Assignee:

Quanterix Corporation - Billerica MA

International Classification:

G01N 33/68
G01N 33/543

Abstract:

The present invention, in some embodiments, generally relates to methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury. In some embodiments, the brain injury results from a hypoxic event. In some embodiments, methods are provided for determining a measure of the concentration of tau protein in a patient sample containing or suspected of containing tau protein.

US Patent:

20220229074, Jul 21, 2022

Filed:

Feb 1, 2022

Appl. No.:

17/589912

Inventors:

- Billerica MA, US
John Henrik Zetterberg - Molnlycke, SE
Kaj Blennow - Kungsbacka, SE
Jeffrey D. Randall - Canton MA, US

Assignee:

Quanterix Corporation - Billerica MA

International Classification:

G01N 33/68
G01N 33/543

Abstract:

The present invention, in some embodiments, generally relates to methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury. In some embodiments, the brain injury results from a hypoxic event. In some embodiments, methods are provided for determining a measure of the concentration of tau protein in a patient sample containing or suspected of containing tau protein.

US Patent:

20230071162, Mar 9, 2023

Filed:

Nov 7, 2022

Appl. No.:

17/981658

Inventors:

- Somerville MA, US
Jeffrey D. Randall - Westford MA, US
John C. Pena - Cambridge MA, US

International Classification:

G01N 33/543
G01N 24/10
G01N 27/74
G01N 33/536
G01N 33/553
G01R 33/26

Abstract:

The present application discloses methods and apparatus for detecting a complex including an analyte that include contacting a sample in a solution with a population of functionalized beads of a first type, which are magnetic functionalized beads and are functionalized to include a first moiety that associates with an analyte under suitable conditions, contacting the sample solution with a population of functionalized beads of a second type, which are functionalized to include a second moiety that associates with the analyte under suitable conditions, contact resulting in formation of a complex including one of the first type of functionalized bead, the analyte, and one of the second type of functionalized bead, and detecting the complex including the analyte by detecting magnetic fields produced by the magnetic functionalized bead and by detecting the functionalized bead of the second type associated with the analyte in the complex.

US Patent:

20210131966, May 6, 2021

Filed:

Jul 30, 2018

Appl. No.:

16/633488

Inventors:

- Somerville MA, US
Giles P. Blaney - Wenham MA, US
Akim Lennhoff - Cambridge MA, US
Jeffrey D. Randall - Cambridge MA, US
Harald Quintus-Bosz - Sudbury MA, US
Stuart E. Schechter - Newton MA, US
Kenneth A. Ritsher - Lowell MA, US
Hooman Hosseinkhannazer - Edmonton, CA
Graham McKinnon - Edmonton, CA

International Classification:

G01N 21/64

Abstract:

The present application discloses a sensor system that includes a sensor having a sensor surface, a sample cartridge including one or more flexible membranes and a membrane frame, the membrane frame including one or more openings covered by the one or more flexible membranes defining one or more wells for holding one or more samples, the flexible membrane having a sample side supporting the sample and an opposite sensor side, the sample cartridge being removably insertable in the sensor system such that the sensor side of the flexible membrane is positioned above and faces the sensor surface, a displacement mechanism that can be actuated to displace the flexible membrane toward the sensor surface such that the sample is moved to a position closer to the sensor surface, and an optical imaging system that detects light emitted from the sensor. Disclosed also are a cartridge cassette and a method of use.