Jeffrey W Randall

US Patent:

7282330, Oct 16, 2007

Filed:

Feb 5, 2004

Appl. No.:

10/773084

Inventors:

Xiaojian (David) Zhao - Westford MA, US
Jeffrey D. Randall - Canton MA, US
Bijit Kundu - Brookline MA, US
Jessica Kesty - Seabrook NH, US
Steven R. Gullans - Natick MA, US
Eugene Y. Chan - Boston MA, US
Martin Fuchs - Uxbridge MA, US
Jenny E. Rooke - Somerville MA, US

Assignee:

U.S. Genomics, Inc. - Woburn MA

International Classification:

C12Q 1/68
C07H 21/02
C07H 21/04

US Classification:

435 6, 536 231, 536 243

Abstract:

The invention relates to methods for analyzing and characterizing single polymers such as nucleic acid molecules. In preferred embodiments, the single molecules are analyzed using single molecule detection and analysis systems.

US Patent:

7371520, May 13, 2008

Filed:

May 28, 2003

Appl. No.:

10/448264

Inventors:

Xiaojian (David) Zhao - Westford MA, US
Jeffrey D. Randall - Canton MA, US
Bijit Kundu - Brookline MA, US
Jessica Kesty - Seabrook NH, US
Steve R. Gullans - Natick MA, US
Eugene Y. Chan - Brookline MA, US
Martin Fuchs - Uxbridge MA, US

Assignee:

U.S. Genomics, Inc. - Woburn MA

International Classification:

C12Q 1/68
C07H 21/02
C07H 21/04

US Classification:

435 6, 536 231, 536 243

Abstract:

The invention relates to methods for analyzing and characterizing single polymers such as nucleic acid molecules. In preferred embodiments, the single molecules are analyzed using single molecule detection and analysis systems.

US Patent:

20230071162, Mar 9, 2023

Filed:

Nov 7, 2022

Appl. No.:

17/981658

Inventors:

- Somerville MA, US
Jeffrey D. Randall - Westford MA, US
John C. Pena - Cambridge MA, US

International Classification:

G01N 33/543
G01N 24/10
G01N 27/74
G01N 33/536
G01N 33/553
G01R 33/26

Abstract:

The present application discloses methods and apparatus for detecting a complex including an analyte that include contacting a sample in a solution with a population of functionalized beads of a first type, which are magnetic functionalized beads and are functionalized to include a first moiety that associates with an analyte under suitable conditions, contacting the sample solution with a population of functionalized beads of a second type, which are functionalized to include a second moiety that associates with the analyte under suitable conditions, contact resulting in formation of a complex including one of the first type of functionalized bead, the analyte, and one of the second type of functionalized bead, and detecting the complex including the analyte by detecting magnetic fields produced by the magnetic functionalized bead and by detecting the functionalized bead of the second type associated with the analyte in the complex.