Jeffrey W Tidwell

US Patent:

6413938, Jul 2, 2002

Filed:

Aug 25, 1999

Appl. No.:

09/367260

Inventors:

Jeffrey H. Tidwell - Raleigh NC
Stanley D. Chamberlain - Research Triangle Park NC
George A. Freeman - Research Triangle Park NC
Joseph H. Chan - Research Triangle Park NC
George W. Koszalka - Research Triangle Park NC
Leroy B. Townsend - Ann Arbor MI
John C. Drach - Ann Arbor MI

Assignee:

The Regents of the University of Michigan - Ann Arbor MI
Glaxo Wellcome Inc. - Research Triangle Park NC

International Classification:

A61K 3170

US Classification:

514 43, 514394, 514934, 536 241, 536 289, 5483047

Abstract:

According to a first aspect of the invention there is provided compounds of formula (I): wherein: R is hydroxy; O-acetyl; or a halo atom; R is hydroxy; O-acetyl; or a halo atom; R is hydrogen; a halo atom; azido; C alkenyl; C alkynyl; C aryl C alkenyl; C arylC alkynyl âNR R (where R and R may be the same or different and are hydrogen, C alkyl, cyanoC alkyl, hydroxyC alkyl, haloC alkyl, C cycloalkyl, C alkylC cycloalkyl, C alkenyl, C cycloalkylC alkyl, C alkynyl, C aryl, C arylC alkyl, heterocycleC alkyl, C alkylcarbonyl, C arylsulfonyl, C alkysulfonyl, or R R together with the N atom to which they are attached form a 3,4,5 or 6 membered heterocyclic ring); âOR (where R is hydrogen, C alkyl, C aryl, or C arylC alkyl, C alkenyl, C alkynyl, C aryl C alkenyl or C arylC alkynyl); or âSR (where R is hydrogen, C alkyl, C aryl, or C arylC alkyl).

US Patent:

6617315, Sep 9, 2003

Filed:

Nov 14, 2000

Appl. No.:

09/712739

Inventors:

Stanley Dawes Chamberlain - Chapel Hill NC 27709
George Walter Koszalka - Chapel Hill NC 27709
Jeffrey H. Tidwell - Raleigh NC 27709
Nanine Agneta Vandraanen - Thousand Oaks CA 91360

International Classification:

C07H 1702

US Classification:

514 43, 514394, 536 289

Abstract:

The present invention relates to benzimidazole derivatives and their use in medical therapy particularly for the treatment or prophylaxis of restenosis.

US Patent:

7160880, Jan 9, 2007

Filed:

May 12, 2000

Appl. No.:

09/980680

Inventors:

Paul L Feldman - Durham NC, US
David Kendall Jung - Durham NC, US
Istvan Kaldor - Durham NC, US
Gregory J. Pacofsky - Durham NC, US
Jeffrey A. Stafford - Durham NC, US
Jeffrey H. Tidwell - Durham NC, US

Assignee:

CeNeS Limited - Cambridge

International Classification:

A61P 25/20
A61K 31/55
C07D 243/14
C07D 243/18
C07D 243/24

US Classification:

514221, 540505, 540509, 540512, 540572

Abstract:

The present invention provides a compound of formula (I):.

US Patent:

7273863, Sep 25, 2007

Filed:

Aug 31, 2000

Appl. No.:

10/070084

Inventors:

Joseph Howing Chan - Durham NC, US
George Andrew Freeman - Durham NC, US
Karen Rene Romines - Durham NC, US
Jeffrey H. Tidwell - Durham NC, US
Pascal Maurice Charles Pianetti - Les Ulis, FR

Assignee:

SmithKline Beecham Corporation - Philadelphia PA

International Classification:

C07D 277/24
A61K 31/16

US Classification:

5142275, 514249, 514365, 514469, 514621, 544 59, 544356, 548200, 549468, 564169

Abstract:

The present invention includes benzophenone compounds (I).

US Patent:

7435730, Oct 14, 2008

Filed:

Jan 5, 2007

Appl. No.:

11/650637

Inventors:

Paul L. Feldman - Research Triangle Park NC, US
David Kendall Jung - Research Triangle Park NC, US
Istvan Kaldor - Research Triangle Park NC, US
Gregory J. Pacofsky - Research Triangle Park NC, US
Jeffrey A. Stafford - Research Triangle Park NC, US
Jeffrey H. Tidwell - Research Triangle Park NC, US

Assignee:

CeNeS Limited - Cambridge

International Classification:

A61P 25/00
A61K 31/55
C07D 487/12

US Classification:

514220, 540562

Abstract:

The present invention provides a compound of formula (I):.

US Patent:

7473689, Jan 6, 2009

Filed:

Jan 5, 2007

Appl. No.:

11/650635

Inventors:

Paul L. Feldman - Research Triangle Park NC, US
David Kendall Jung - Research Triangle Park NC, US
Istvan Kaldor - Research Triangle Park NC, US
Gregory J. Pacofsky - Research Triangle Park NC, US
Jeffrey A. Stafford - Research Triangle Park NC, US
Jeffrey H. Tidwell - Research Triangle Park NC, US

Assignee:

CeNes Limited - Cambridge

International Classification:

A61P 25/20
A61K 31/55
C07D 487/12

US Classification:

514220, 540563, 540565, 540566

Abstract:

The present invention provides a compound of formula (I):.

US Patent:

7485635, Feb 3, 2009

Filed:

Dec 5, 2006

Appl. No.:

11/634788

Inventors:

Paul L. Feldman - Research Triangle Park NC, US
David Kendall Jung - Research Triangle Park NC, US
Istvan Kaldor - Research Triangle Park NC, US
Gregory J. Pacofsky - Research Triangle Park NC, US
Jeffrey A. Stafford - Research Triangle Park NC, US
Jeffrey H. Tidwell - Research Triangle Park NC, US

Assignee:

CeNes Limited - Cambridge

International Classification:

A61P 25/20
A61K 31/55
C07D 487/04

US Classification:

514220, 540562

Abstract:

The present invention provides a compound of formula (I):.

US Patent:

7528127, May 5, 2009

Filed:

Jan 5, 2007

Appl. No.:

11/650636

Inventors:

Paul L. Feldman - Research Triangle Park NC, US
David Kendall Jung - Research Triangle Park NC, US
Istvan Kaldor - Research Triangle Park NC, US
Gregory J. Pacofsky - Research Triangle Park NC, US
Jeffrey A. Stafford - Research Triangle Park NC, US
Jeffrey H. Tidwell - Research Triangle Park NC, US

Assignee:

CeNes Limited - Cambridge

International Classification:

A61P 25/20
A61K 31/5517
C07D 487/02

US Classification:

514220, 540561

Abstract:

It has now been found that compounds of the present invention as described in Benzodiazepine derivatives of Formula (I) containing a carboxylic ester moiety and thereby capable of being inactivated by nonspecific tissue esterases in an organ-independent elimination mechanism and thereby providing a more predictable and reproducible pharmacodynamic profile. The compounds of the present invention are suitable for therapeutic purposes, including sedative-hypnotic, anxiolytic, muscle relaxant and anticonvulsant purposes and are useful to be administered intravenously in the following clinical settings: preoperative sedation, anxiolysis, and amnestic use for perioperative events; conscious sedation during short diagnostic, operative or endoscopic procedures; as a component for the induction and maintenance of general anesthesia, prior and/or concomitant to the administration of other anesthetic agents; ICU sedation.