Jeffrey W Tidwell

US Patent:

6617315, Sep 9, 2003

Filed:

Nov 14, 2000

Appl. No.:

09/712739

Inventors:

Stanley Dawes Chamberlain - Chapel Hill NC 27709
George Walter Koszalka - Chapel Hill NC 27709
Jeffrey H. Tidwell - Raleigh NC 27709
Nanine Agneta Vandraanen - Thousand Oaks CA 91360

International Classification:

C07H 1702

US Classification:

514 43, 514394, 536 289

Abstract:

The present invention relates to benzimidazole derivatives and their use in medical therapy particularly for the treatment or prophylaxis of restenosis.

US Patent:

7160880, Jan 9, 2007

Filed:

May 12, 2000

Appl. No.:

09/980680

Inventors:

Paul L Feldman - Durham NC, US
David Kendall Jung - Durham NC, US
Istvan Kaldor - Durham NC, US
Gregory J. Pacofsky - Durham NC, US
Jeffrey A. Stafford - Durham NC, US
Jeffrey H. Tidwell - Durham NC, US

Assignee:

CeNeS Limited - Cambridge

International Classification:

A61P 25/20
A61K 31/55
C07D 243/14
C07D 243/18
C07D 243/24

US Classification:

514221, 540505, 540509, 540512, 540572

Abstract:

The present invention provides a compound of formula (I):.

US Patent:

7273863, Sep 25, 2007

Filed:

Aug 31, 2000

Appl. No.:

10/070084

Inventors:

Joseph Howing Chan - Durham NC, US
George Andrew Freeman - Durham NC, US
Karen Rene Romines - Durham NC, US
Jeffrey H. Tidwell - Durham NC, US
Pascal Maurice Charles Pianetti - Les Ulis, FR

Assignee:

SmithKline Beecham Corporation - Philadelphia PA

International Classification:

C07D 277/24
A61K 31/16

US Classification:

5142275, 514249, 514365, 514469, 514621, 544 59, 544356, 548200, 549468, 564169

Abstract:

The present invention includes benzophenone compounds (I).

US Patent:

7435730, Oct 14, 2008

Filed:

Jan 5, 2007

Appl. No.:

11/650637

Inventors:

Paul L. Feldman - Research Triangle Park NC, US
David Kendall Jung - Research Triangle Park NC, US
Istvan Kaldor - Research Triangle Park NC, US
Gregory J. Pacofsky - Research Triangle Park NC, US
Jeffrey A. Stafford - Research Triangle Park NC, US
Jeffrey H. Tidwell - Research Triangle Park NC, US

Assignee:

CeNeS Limited - Cambridge

International Classification:

A61P 25/00
A61K 31/55
C07D 487/12

US Classification:

514220, 540562

Abstract:

The present invention provides a compound of formula (I):.

US Patent:

7473689, Jan 6, 2009

Filed:

Jan 5, 2007

Appl. No.:

11/650635

Inventors:

Paul L. Feldman - Research Triangle Park NC, US
David Kendall Jung - Research Triangle Park NC, US
Istvan Kaldor - Research Triangle Park NC, US
Gregory J. Pacofsky - Research Triangle Park NC, US
Jeffrey A. Stafford - Research Triangle Park NC, US
Jeffrey H. Tidwell - Research Triangle Park NC, US

Assignee:

CeNes Limited - Cambridge

International Classification:

A61P 25/20
A61K 31/55
C07D 487/12

US Classification:

514220, 540563, 540565, 540566

Abstract:

The present invention provides a compound of formula (I):.

US Patent:

7485635, Feb 3, 2009

Filed:

Dec 5, 2006

Appl. No.:

11/634788

Inventors:

Paul L. Feldman - Research Triangle Park NC, US
David Kendall Jung - Research Triangle Park NC, US
Istvan Kaldor - Research Triangle Park NC, US
Gregory J. Pacofsky - Research Triangle Park NC, US
Jeffrey A. Stafford - Research Triangle Park NC, US
Jeffrey H. Tidwell - Research Triangle Park NC, US

Assignee:

CeNes Limited - Cambridge

International Classification:

A61P 25/20
A61K 31/55
C07D 487/04

US Classification:

514220, 540562

Abstract:

The present invention provides a compound of formula (I):.

US Patent:

7528127, May 5, 2009

Filed:

Jan 5, 2007

Appl. No.:

11/650636

Inventors:

Paul L. Feldman - Research Triangle Park NC, US
David Kendall Jung - Research Triangle Park NC, US
Istvan Kaldor - Research Triangle Park NC, US
Gregory J. Pacofsky - Research Triangle Park NC, US
Jeffrey A. Stafford - Research Triangle Park NC, US
Jeffrey H. Tidwell - Research Triangle Park NC, US

Assignee:

CeNes Limited - Cambridge

International Classification:

A61P 25/20
A61K 31/5517
C07D 487/02

US Classification:

514220, 540561

Abstract:

It has now been found that compounds of the present invention as described in Benzodiazepine derivatives of Formula (I) containing a carboxylic ester moiety and thereby capable of being inactivated by nonspecific tissue esterases in an organ-independent elimination mechanism and thereby providing a more predictable and reproducible pharmacodynamic profile. The compounds of the present invention are suitable for therapeutic purposes, including sedative-hypnotic, anxiolytic, muscle relaxant and anticonvulsant purposes and are useful to be administered intravenously in the following clinical settings: preoperative sedation, anxiolysis, and amnestic use for perioperative events; conscious sedation during short diagnostic, operative or endoscopic procedures; as a component for the induction and maintenance of general anesthesia, prior and/or concomitant to the administration of other anesthetic agents; ICU sedation.

US Patent:

62042491, Mar 20, 2001

Filed:

Jul 13, 1998

Appl. No.:

9/101103

Inventors:

Stanley Dawes Chamberlain - Chapel Hill NC
George Walter Koszalka - Chapel Hill NC
Jeffrey H. Tidwell - Raleigh NC
Nanine Agneta Vandraanen - Thousand Oaks CA

Assignee:

Glaxo Wellcome Inc. - Research Triangle Park NC

International Classification:

C07H 1702
C07D23504
A61K 3170

US Classification:

514 43

Abstract:

The present invention relates to benzimidazole derivatives and their use in medical therapy particularly for the treatment or prophylaxis of virus infections such as those caused by herpes viruses. The invention also relates to the preparation of the benzimidazole derivatives and pharmaceutical formulations containing them.