Jeffrey A Tonn

US Patent:

7544506, Jun 9, 2009

Filed:

Jun 7, 2004

Appl. No.:

10/862826

Inventors:

Wayne Breidford - Seattle WA, US
Christy A Lancaster - Seattle WA, US
Jon Wallace Hayenga - Redmond WA, US
Ronald L Bardell - St. Louis Park MN, US
Jeffrey F Tonn - Tacoma WA, US
Bernhard H Weigl - Seattle WA, US

Assignee:

Micronics, Inc. - Redmond WA

International Classification:

C12M 1/34
C12M 3/00

US Classification:

4352885, 4352872, 4352887, 4353031, 435809

Abstract:

An integrated heat exchange system on a microfluidic card. According to one aspect of the invention, the portable microfluidic card has a heating, cooling and heat cycling system on-board such that the card can be used portably. The microfluidic card includes one or more reservoirs containing exothermic or endothermic material. Once the chemical process of the reservoir material is activated, the reservoir provides heat or cooling to specific locations of the microfluidic card. Multiple reservoirs may be included on a single card to provide varying temperatures. The assay chemicals can be moved to the various reservoirs to create a thermal cycle useful in many biological reactions, for example, Polymerase Chain Reaction (PCR) or rtPCR. According to another aspect of the invention, the integrated heat exchanger is an adjacent microfluidic circuit containing fluid that is either independently heated or cooled, or is an exothermic or endothermic material, such that the fluid in the adjacent circuit imparts a change in temperature to the assay fluid in an independent circuit. According to yet another aspect of the invention, a thermal electric cooler (TEC) is used for thermocycling the amplification chamber of a disposable microfluidic card.

US Patent:

7648835, Jan 19, 2010

Filed:

Aug 27, 2008

Appl. No.:

12/199613

Inventors:

Wayne L. Breidford - Seattle WA, US
Christy A. Lancaster - Seattle WA, US
Jon W. Hayenga - Redmond WA, US
Ronald L. Bardell - St. Louis Park MN, US
Jeffrey F. Tonn - Tacoma WA, US
Bernhard H. Weigl - Seattle WA, US

Assignee:

Micronics, Inc. - Redmond WA

International Classification:

C12M 1/34
C12M 3/00

US Classification:

4352885

Abstract:

An integrated heat exchange system on a microfluidic card. According to one aspect of the invention, the portable microfluidic card has a heating, cooling and heat cycling system on-board such that the card can be used portably. The microfluidic card includes one or more reservoirs containing exothermic or endothermic material. Once the chemical process of the reservoir material is activated, the reservoir provides heat or cooling to specific locations of the microfluidic card. Multiple reservoirs may be included on a single card to provide varying temperatures. The assay chemicals can be moved to the various reservoirs to create a thermal cycle useful in many biological reactions, for example, Polymerase Chain Reaction (PCR) or rtPCR. According to another aspect of the invention, the integrated heat exchanger is an adjacent microfluidic circuit containing fluid that is either independently heated or cooled, or is an exothermic or endothermic material, such that the fluid in the adjacent circuit imparts a change in temperature to the assay fluid in an independent circuit. According to yet another aspect of the invention, a thermal electric cooler (TEC) is used for thermocycling the amplification chamber of a disposable microfluidic card.

US Patent:

47062592, Nov 10, 1987

Filed:

Dec 30, 1985

Appl. No.:

6/815352

Inventors:

Jerome M. Paros - Kirkland WA
Jeffrey F. Tonn - Tacoma WA
Richard B. Wearn - Seattle WA

Assignee:

Sundstrand Data Control, Inc. - Redmond WA

International Classification:

G01K 1122

US Classification:

374117

Abstract:

Prior mounting systems for tuning fork temperature sensors have resulted in unpredictable activity dips within the sensor operating ranges. This problem is eliminated by the mounting and isolation system (32) of the present invention that is adapted to mount temperature sensitive tuning fork (20) to a support structure. The mounting system comprises a mounting member (34) adapted for rigid connection to the support structure, and support means (36) connecting the tuning fork base to the mounting member such that the tuning fork is supported solely by the support means. The support means comprises a low pass mechanical filter that transmits only vibration frequencies that are less than the operating range of frequencies of the tuning fork.

US Patent:

45178410, May 21, 1985

Filed:

Jan 6, 1983

Appl. No.:

6/456254

Inventors:

Rex B. Peters - Woodinville WA
Jeffrey F. Tonn - Tacoma WA
Arnold Malametz - Carnation WA
Richard A. Hilliker - Seattle WA
Victor B. Corey - Bellevue WA

Assignee:

Sundstrand Data Control, Inc. - Redmond WA

International Classification:

G01P 1510

US Classification:

73517AV

Abstract:

An accelerometer includes a hinged proof mass constrained from movement by a beam resonator force transducer. To afford greater movement of the proof mass and greater latitude in positioning mechanical stops, one end of the force transducer is connected with the accelerometer base through a compliant mount. The other end of the force transducer is connected with the proof mass at the center of percussion of the proof mass. Adjacent surfaces of the proof mass and base provide squeeze film viscous gas damping. A pair of proof mass-force transducer systems are mounted on a carrier in opposite positions with the sensitive axes of the proof masses aligned and the proof mass hinge axes parallel and opposed to each other.

US Patent:

44676514, Aug 28, 1984

Filed:

Jan 6, 1983

Appl. No.:

6/456255

Inventors:

Rex B. Peters - Woodinville WA
Arnold Malametz - Carnation WA
Jeffrey F. Tonn - Tacoma WA
Charles K. Lee - Seattle WA
Aleksandar M. Gogic - Seattle WA
Victor B. Corey - Bellevue WA

Assignee:

Sundstrand Data Control, Inc. - Redmond WA

International Classification:

G01P 1510

US Classification:

73497

Abstract:

An accelerometer has two proof masses each constrained from movement by a beam resonant force transducer. The proof mass-force transducer systems are mounted with the sensitive axes of the proof masses aligned and the force transducers arranged so that their resonant frequencies f. sub. 1 and f. sub. 2 vary oppositely with a change in acceleration. The acceleration is determined in accordance with the relation a=A. sub. 1 f. sub. 1 -A. sub. 2 f. sub. 3 +A. sub. 0 or a=A. sub. 1 f. sub. 1. sup. 2 -A. sub. 2 f. sub. 2. sup. 2 +A. sub. 0 where a is the acceleration and A. sub. 1, A. sub. 2 and A. sub. 0 are calibration coefficients.

US Patent:

52129845, May 25, 1993

Filed:

Aug 13, 1992

Appl. No.:

7/930473

Inventors:

Brian L. Norling - Mill Creek WA
Jeffrey F. Tonn - Tacoma WA

Assignee:

Sundstrand Corporation - Rockford IL

International Classification:

G01P 1500

US Classification:

73493

Abstract:

The mounting system of the present invention is adapted to support a precision transducer (14) in spaced alignment with a supporting case (12). The mounting system comprises a plurality of mounting elements (30), each mounting element having one end (34), an opposite end (32) and a resilient intermediate portion (36). One end is adapted to be connected to the transducer, and the opposite end is adapted to be connected to the case. Adjacent mounting elements are joined to one another by bridge sections (38) to form a continuous mounting ring (16) and to define a plurality of gaps (56). At least the end connected to the transducer and bridge sections is composed of a substance that has a coefficient of thermal expansion approximately equal to the coefficient of thermal expansion of the transducer. Each intermediate portion is configured to provide a low resistance to relative movement between the transducer and case in a radial direction, and a high resistance to relative movement in other directions.