Jennifer A Ayres

US Patent:

8618509, Dec 31, 2013

Filed:

Jan 2, 2013

Appl. No.:

13/732882

Inventors:

Jonathan P. Scaffidi - Durham NC, US
Venkata Gopal Reddy Chada - Durham NC, US
Benoit Lauly - Durham NC, US
Yan Zhang - Durham NC, US
Molly K. Gregas - Durham NC, US
Ian Nicholas Stanton - Durham NC, US
Joshua T. Stecher - Durham NC, US
Michael J. Therien - Durham NC, US
Zak Fathi - Raleigh NC, US
Jennifer Ann Ayres - Raleigh NC, US
Zhenyuan Zhang - Durham NC, US
Joseph H. Simmons - Tucson AR, US
Stephen John Norton - Cary NC, US

Assignee:

Immunolight, LLC - Detroit MI
Duke University - Durham NC

International Classification:

G01J 1/58

US Classification:

2504591

Abstract:

A system for energy upconversion and/or down conversion and a system for producing a photostimulated reaction in a medium. These systems include 1) a nanoparticle configured, upon exposure to a first wavelength λof radiation, to generate a second wavelength λof radiation having a higher energy than the first wavelength λand 2) a metallic structure disposed in relation to the nanoparticle. A physical characteristic of the metallic structure is set to a value where a surface plasmon resonance in the metallic structure resonates at a frequency which provides a spectral overlap with either the first wavelength λor the second wavelength λ, or with both λand λ. The system for producing a photostimulated reaction in a medium includes a receptor disposed in the medium in proximity to the nanoparticle which, upon activation by the second wavelength λ, generates the photostimulated reaction.

US Patent:

20100261263, Oct 14, 2010

Filed:

Mar 16, 2010

Appl. No.:

12/725108

Inventors:

Tuan VO-DINH - Chapel Hill NC, US
Jonathan P. SCAFFIDI - Durham NC, US
Venkata Gopal Reddy CHADA - Durham NC, US
Benoit LAULY - Durham NC, US
Yan ZHANG - Durham NC, US
Molly K. GREGAS - Durham NC, US
Ian N. STANTON - Durham NC, US
Joshua T. STECHER - Durham NC, US
Michael J. THERIEN - Durham NC, US
Zak FATHI - Raleigh NC, US
Jennifer A. AYRES - Raleigh NC, US
Zhenyuan ZHANG - Durham NC, US
Joseph H. SIMMONS - Tucson AZ, US
Stephen John Norton - Cary NC, US

Assignee:

Duke University - Durham NC
Immunolight, LLC - Detroit MI

International Classification:

B32B 5/16
B01J 19/08
B01J 19/12
G01N 30/96
B01J 19/00
C12M 1/34
C08F 2/46
F21V 9/16
A61L 2/08
G21K 1/00
G01N 21/63
A61N 5/06

US Classification:

4352871, 422186, 4221863, 422 69, 422131, 428323, 428328, 522 1, 2504591, 250432 R, 2504581, 607 88, 977700, 977773

Abstract:

A system for energy upconversion and/or down conversion and a system for producing a photostimulated reaction in a medium. These systems include 1) a nanoparticle configured, upon exposure to a first wavelength λof radiation, to generate a second wavelength λof radiation having a higher energy than the first wavelength λand 2) a metallic structure disposed in relation to the nanoparticle. A physical characteristic of the metallic structure is set to a value where a surface plasmon resonance in the metallic structure resonates at a frequency which provides a spectral overlap with either the first wavelength λor the second wavelength λ, or with both λand λ. The system for producing a photostimulated reaction in a medium includes a receptor disposed in the medium in proximity to the nanoparticle which, upon activation by the second wavelength λ, generates the photostimulated reaction.

US Patent:

20110021970, Jan 27, 2011

Filed:

Apr 21, 2010

Appl. No.:

12/764184

Inventors:

Tuan VO-DINH - Chapel Hill NC, US
Jonathan P. SCAFFIDI - Durham NC, US
Venkata Gopal Reddy CHADA - Durham NC, US
Benoit LAULY - Durham NC, US
Yan ZHANG - Durham NC, US
Molly K. GREGAS - Durham NC, US
Ian N. STANTON - Durham NC, US
Joshua T. STECHER - Durham NC, US
Michael J. THERIEN - Durham NC, US
Harold WALDER - Belville NC, US
Zak FATHI - Raleigh NC, US
Jennifer A. AYRES - Raleigh NC, US
Zhenyuan ZHANG - Durham NC, US
Joseph H. SIMMONS - Tucson AZ, US
Stephen John NORTON - Cary NC, US

Assignee:

Duke University - Durham NC
Immunolight, LLC - Detroit MI

International Classification:

A61M 37/00
G02F 1/01
A61K 35/12
A61K 39/00
A61K 9/16
B82Y 5/00

US Classification:

604 20, 359241, 424 937, 4241841, 424490, 977773, 977834, 977906, 977908

Abstract:

Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by placing a nanoparticle having a metallic shell on at least a fraction of a surface in a vicinity of a target structure in a subject and applying an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The nanoparticle is configured, upon exposure to a first wavelength λ, to generate a second wavelength λof radiation having a higher energy than the first wavelength λ. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.

US Patent:

20120089180, Apr 12, 2012

Filed:

May 6, 2011

Appl. No.:

13/102277

Inventors:

Zakaryae Fathi - Detroit MI, US
James Clayton - Detroit MI, US
Harold Walder - Detroit MI, US
Ian Stanton - Durham NC, US
Jennifer Ayres - Raleigh NC, US
Joshua T. Stecher - Durham NC, US
Michael Therien - Durham NC, US
Eric Toone - Durham NC, US
Dave Gooden - Durham NC, US
Mark Dewhirst - Durham NC, US
Joseph A. Herbert - Richmond VA, US
Diane Fels - Morrisville NC, US
Katherine S. Hansen - Davis CA, US

Assignee:

Duke University - Durham NC
Immunolight, LLC - Detroit MI

International Classification:

A61B 17/03
G03F 7/038
C09D 163/10
H01B 1/12
C09D 167/07
G21K 5/00
B41J 2/175
H01L 23/28
B32B 37/12
B32B 38/14
B32B 7/12
C09D 7/12
C09D 4/02
B82Y 30/00

US Classification:

606214, 522 16, 4302701, 525418, 2525011, 378 64, 347 86, 257787, 1562755, 1562726, 428355 R, 977773, 257E23116

Abstract:

A polymerizable composition includes at least one monomer, a photoinitiator capable of initiating polymerization of the monomer when exposed to light, and a phosphor capable of producing light when exposed to radiation (typically X-rays). The material is particularly suitable for bonding components at ambient temperature in situations where the bond joint is not accessible to an external light source. An associated method includes: placing a polymerizable adhesive composition, including a photoinitiator and energy converting material, such as a down-converting phosphor, in contact with at least two components to be bonded to form an assembly; and, irradiating the assembly with radiation at a first wavelength, capable of conversion (down-conversion by the phosphor) to a second wavelength capable of activating the photoinitiator, to prepare items such as inkjet cartridges, wafer-to-wafer assemblies, semiconductors, integrated circuits, and the like.

US Patent:

20200368547, Nov 26, 2020

Filed:

Apr 28, 2020

Appl. No.:

16/860623

Inventors:

- Detroit MI, US
- Durham NC, US
Zakaryae FATHI - Raleigh NC, US
Michael J. THERIEN - Durham NC, US
Mark W. DEWHIRST - Chapel Hill NC, US
Ian N. STANTON - Durham NC, US
Jennifer Ann AYRES - Raleigh NC, US
Diane Renee FELS - Cincinnati OH, US
Joseph A. HERBERT - Richmond VA, US

Assignee:

IMMUNOLIGHT, LLC. - Detroit MI
DUKE UNIVERSITY - Durham NC

International Classification:

A61N 5/06
A61K 41/00
A61N 5/10

Abstract:

A method for treating a disease, disorder, or condition in a subject in need thereof, by administering either or both of (i) at least one photoactivatable pharmaceutical agent, or (ii) a first plurality of energy-emitting particles, into the subject in a region of the disease, disorder, or condition, whereby the administering is performed through inhalation; and applying an applied electromagnetic energy to the subject, wherein the applied electromagnetic energy directly or indirectly activates the at least one photoactivatable pharmaceutical agent, when present, and wherein when the first plurality of energy-emitting particles is present, the first plurality of energy-emitting particles absorbs the applied energy and emits an emitted electromagnetic energy, wherein the emitted electromagnetic energy interacts directly with the region of the disease, disorder, or condition or activates the at least one photoactivatable pharmaceutical agent.

US Patent:

20200078600, Mar 12, 2020

Filed:

Jul 19, 2019

Appl. No.:

16/516463

Inventors:

- Detroit MI, US
- Durham NC, US
Venkata Gopal Reddy CHADA - Durham NC, US
Benoit LAULY - Durham NC, US
Yan ZHANG - Durham NC, US
Molly K. GREGAS - Durham NC, US
Ian Nicholas STANTON - Durham NC, US
Joshua T. STECHER - Durham NC, US
Michael J. THERIEN - Durham NC, US
Harold WALDER - Oak Island NC, US
Zak FATHI - Raleigh NC, US
Jennifer A. AYRES - Raleigh NC, US
Zhenyuan ZHANG - Durham NC, US
Joseph H. SIMMONS - Tucson AZ, US
Stephen John NORTON - Cary NC, US

Assignee:

Immunolight, LLC. - Detroit MI
Duke University - Durham NC

International Classification:

A61N 5/06
A61K 49/00
A61N 1/40
A61N 5/02
A61B 5/00
A61B 5/055
A61B 6/00
A61K 41/00
A61M 5/00
A61L 2/00

Abstract:

Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by placing a nanoparticle having a metallic shell on at least a fraction of a surface in a vicinity of a target structure in a subject and applying an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The nanoparticle is configured, upon exposure to a first wavelength λ, to generate a second wavelength λof radiation having a higher energy than the first wavelength λ. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.

US Patent:

20190336785, Nov 7, 2019

Filed:

Jul 15, 2019

Appl. No.:

16/511536

Inventors:

- Detroit MI, US
- Durham NC, US
Venkata Gopal Reddy Chada - Durham NC, US
Benoit Lauly - Durham NC, US
Yan Zhang - Durham NC, US
Molly K. Gregas - Durham NC, US
Ian Nicholas Stanton - Durham NC, US
Joshua T. Stecher - Durham NC, US
Michael J. Therien - Durham NC, US
Harold Walder - Oak Island NC, US
Zak Fathi - Raleigh NC, US
Jennifer A. Ayres - Raleigh NC, US
Zhenyuan Zhang - Durham NC, US
Joseph H. Simmons - Tucson AZ, US
Stephen John Norton - Cary NC, US

Assignee:

IMMUNOLIGHT, LLC - Detroit MI
DUKE UNIVERSITY - Durham NC

International Classification:

A61N 5/06
A61B 5/00
A61L 2/00
A61K 49/00
A61M 5/00
A61K 41/00
A61N 1/40
A61N 5/02
A61B 6/00
A61B 5/055

Abstract:

Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by placing a nanoparticle having a metallic shell on at least a fraction of a surface in a vicinity of a target structure in a subject and applying an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The nanoparticle is configured, upon exposure to a first wavelength λ, to generate a second wavelength λof radiation having a higher energy than the first wavelength λ. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.

US Patent:

20190168015, Jun 6, 2019

Filed:

Jan 18, 2019

Appl. No.:

16/251973

Inventors:

- Detroit MI, US
- Durham NC, US
Zakaryae Fathi - Raleigh NC, US
Michael J. Therien - Durham NC, US
Mark W. Dewhirst - Chapel Hill NC, US
Ian N. Stanton - Durham NC, US
Jennifer Ann Ayres - Raleigh NC, US
Diane Renee Fels - Cincinnati OH, US
Joseph A. Herbert - Richmond VA, US

Assignee:

IMMUNOLIGHT, LLC. - Detroit MI
DUKE UNIVERSITY - Durham NC

International Classification:

A61N 5/06
A61N 5/10
A61K 41/00

Abstract:

A system and method for light stimulation within a medium. The system has a reduced-voltage x-ray source configured to generate x-rays from a peak applied cathode voltage at or below 105 kVp, and a plurality of energy-emitting particles in the medium which, upon radiation from the x-ray source, radiate at a first lower energy than the x-ray source to interact witht least one photoactivatable agent in the medium. The method introduces the plurality of energy-emitting particles into the medium, radiates the energy-emitting particles in the medium with x-rays generated from a peak applied cathode voltage at or below 105 kVp; and emits a lower energy than the x-ray source to interact with the medium or with at least one photoactivatable agent in the medium.