Jennifer L Cuthbert

US Patent:

56681712, Sep 16, 1997

Filed:

Nov 8, 1993

Appl. No.:

8/148148

Inventors:

Jennifer A. Cuthbert - Dallas TX
Peter E. Lipsky - Dallas TX

Assignee:

Board of Regents, The University of Texas System - Austin TX

International Classification:

A61K 3135

US Classification:

514460

Abstract:

Compositions that include as an active ingredient an effective concentration of a halogenated mevalonate preparation, particularly, Fmev (fluoromevalonate) are provided. The pharmacological activity of halogenated mevalonate for inhibiting ras-dependent cell growth, particularly ras-dependent tumor cell growth, is described. Methods for using preparations including a therapeutically effective concentration of Fmev for the inhibition of ras-dependent cell growth, as well as in the treatment and inhibition of ras-dependent tumors is also disclosed. The claimed compositions may be provided in liquid, salve, tablet, or capsule form, as well as other forms suitable for administration to an animal.