Jennifer Downing

US Patent:

20210323975, Oct 21, 2021

Filed:

Aug 8, 2019

Appl. No.:

17/266026

Inventors:

- Boston MA, US
Pui Yee NG - Lexington MA, US
Zhongguo WANG - Lexington MA, US
Tatiana SHELEKHIN - Ridgefield CT, US
Justin CARAVELLA - Cambridge MA, US
Mary-Margaret ZABLOCKI - Revere MA, US
Jennifer R. DOWNING - Clinton MA, US
Hongbin LI - Madison CT, US
Stephanos IOANNIDIS - Natick MA, US

International Classification:

C07D 495/04
C07D 513/04
C07D 519/00

Abstract:

The present disclosure relates to modulators, such as inhibitors, of at least one pathway chosen from USP28 and USP25, pharmaceutical compositions comprising the inhibitors, and methods of using the inhibitors. The modulators, such as inhibitors, of at least one pathway chosen from USP28 and USP25 can be useful in the treatment of cancers, among other ailments.

US Patent:

20210032251, Feb 4, 2021

Filed:

Jul 30, 2020

Appl. No.:

16/942857

Inventors:

- Cambridge MA, US
Melissa Marie Vasbinder - Cambridge MA, US
Kevin Wayne Kuntz - Cambridge MA, US
Nicholas Robert Perl - Cambridge MA, US
Jennifer Downing - Cambridge MA, US

International Classification:

C07D 487/04
A61P 35/00
C07D 403/10
C07D 417/10
C07D 471/04
C07D 495/04
C07D 513/04
C07D 473/32

Abstract:

The present invention relates to heterobicyclic amides and related compounds which are inhibitors of CD38 and are useful in the treatment of cancer.

US Patent:

20200299295, Sep 24, 2020

Filed:

Jun 8, 2020

Appl. No.:

16/946159

Inventors:

- Watertown MA, US
Torsten Herbertz - Stow MA, US
Hongbin Li - Madison CT, US
Bradford Graves - Nutley NJ, US
Steven Mischke - Waltham MA, US
Angela West - Franklin MA, US
Jennifer R. Downing - Clinton MA, US
Anna Ericsson - Shrewsbury MA, US

International Classification:

C07D 471/04

Abstract:

The present disclosure is directed to inhibitors of the CBP/p300 family of bromodomains. The compounds can be useful in the treatment of disease or disorders associated with the inhibition of the CBP/p300 family of bromodomains. For instance, the disclosure is concerned with compounds and compositions for inhibition of the CBP/p300 family of bromodomains, methods of treating, preventing, or ameliorating diseases or disorders associated with the inhibition of CBP/p300 family of bromodomains, and methods of synthesis of these compounds.

US Patent:

20200216445, Jul 9, 2020

Filed:

Sep 14, 2018

Appl. No.:

16/647478

Inventors:

- Watertown MA, US
Torsten Herbertz - Stow MA, US
Hongbin Li - Madison CT, US
Bradford Graves - Nutley NJ, US
Steven Mischke - Waltham MA, US
Angela V. West - Franklin MA, US
Jennifer R. Downing - Clinton MA, US
Anna Ericsson - Shrewsbury MA, US

International Classification:

C07D 471/04
C07D 519/00
A61P 35/00

Abstract:

The present disclosure is directed to inhibitors of the CBP/p300 family of bromodomains. The compounds can be useful in the treatment of disease or disorders associated with the inhibition of the CBP/p300 family of bromodomains. For instance, the disclosure is concerned with compounds and compositions for inhibition of the CBP/p300 family of bromodomains, methods of treating, preventing, or ameliorating diseases or disorders associated with the inhibition of CBP/p300 family of bromodomains, and methods of synthesis of these compounds.

US Patent:

20200002332, Jan 2, 2020

Filed:

Jun 28, 2019

Appl. No.:

16/457596

Inventors:

- Watertown MA, US
Torsten Herbertz - Stow MA, US
Hongbin Li - Madison CT, US
Bradford Graves - Nutley NJ, US
Steven Mischke - Waltham MA, US
Angela West - Franklin MA, US
Jennifer R. Downing - Clinton MA, US
Anna Ericsson - Shrewsbury MA, US

International Classification:

C07D 471/04

Abstract:

The present disclosure is directed to inhibitors of the CBP/p300 family of bromodomains. The compounds can be useful in the treatment of disease or disorders associated with the inhibition of the CBP/p300 family of bromodomains. For instance, the disclosure is concerned with compounds and compositions for inhibition of the CBP/p300 family of bromodomains, methods of treating, preventing, or ameliorating diseases or disorders associated with the inhibition of CBP/p300 family of bromodomains, and methods of synthesis of these compounds.