Jennifer E Foley

US Patent:

20220371005, Nov 24, 2022

Filed:

Aug 3, 2022

Appl. No.:

17/817204

Inventors:

- San Diego CA, US
Kay KLAUSING - San Diego CA, US
Bradley Kent DREWS - Poway CA, US
Nicholas WATSON - San Diego CA, US
Jennifer Olivia FOLEY - San Diego CA, US
Murphy HITCHCOCK - San Diego CA, US
Paul SANGIORGIO - San Diego CA, US

Assignee:

Illumina, Inc. - San Diego CA

International Classification:

B01L 3/00

Abstract:

A system includes a fluidic device, a flow control valve, a first reagent fluid reservoir fluidly connectable to the fluidic device by the flow control valve, a first fluid buffer reservoir fluidly connectable to the fluidic device by the flow control valve, and a common fluid buffer source fluidly connectable to the fluidic device by the flow control valve. The flow control valve permits flow comprising: (i) flow from the first reagent fluid reservoir to the fluidic device, (ii) flow from the common fluid buffer source to the fluidic device, (iii) flow from the fluidic device to the first fluid buffer reservoir, (iv) flow from the first reagent fluid reservoir to the fluidic device, and (v) flow from the first fluid buffer reservoir to the fluidic device.

US Patent:

20220323955, Oct 13, 2022

Filed:

Jun 29, 2022

Appl. No.:

17/809604

Inventors:

- San Diego CA, US
Jay TAYLOR - San Diego CA, US
Minsoung RHEE - San Diego CA, US
Jennifer FOLEY - San Diego CA, US
Cyril DELATTRE - San Diego CA, US
Tarun KHURANA - San Diego CA, US
Paul CRIVELLI - San Diego CA, US

Assignee:

Illumina, Inc. - San Diego CA

International Classification:

B01L 3/00
G01N 21/05

Abstract:

An example method includes connecting a flow cell to an instrument. The flow cell includes a flow channel including a manifold section having a manifold section swept volume and a detection section having a detection section swept volume. A ratio of the detection section swept volume to manifold section swept volume is at least 10 to 1. A first reagent is pumped through the flow channel. A first chemical reaction is performed between the first reagent and analytes positioned in the detection section. A subsequent reagent is pumped through the flow channel to flush out the remaining reagent. A concentration of at least 99.95 percent of reagent positioned in the detection section is the subsequent reagent, after pumping a total volume of the subsequent reagent through the flow channel that is equal to or less than 2.5 times a total swept volume of the manifold section plus the detection section.

US Patent:

20210154667, May 27, 2021

Filed:

Feb 2, 2021

Appl. No.:

17/165757

Inventors:

- San Diego CA, US
- Cambridge, GB
Oliver Jon Miller - Cambridge, GB
Jennifer Olivia Foley - San Diego CA, US
Tarun Kumar Khurana - San Diego CA, US
Paul Crivelli - San Diego CA, US
Gary Watts - San Diego CA, US

Assignee:

Illumina, Inc. - San Diego CA
Illumina Cambridge Limited - Cambridge

International Classification:

B01L 3/00
G01N 1/31

Abstract:

An apparatus for directing fluid into and out of a fluidic device includes two or more fluid prime channels connected to a fluid inlet of the fluidic device, a flow control valve for each fluid prime channel to control flow between the fluid prime channel and the fluid inlet, one or more outlet channels connected to a fluid outlet of the fluidic device, and a flow control valve for each outlet channel to control flow between the fluid outlet and the associated outlet channel. An apparatus for delivering fluids to a fluid inlet includes a plate that is rotatable about an axis of rotation and a plurality of fluid compartments disposed on the plate, each compartment having a fluid exit port disposed at a common radial distance from the axis of rotation and positioned to align with the fluid inlet as the plate rotates about the axis of rotation.

US Patent:

20200108382, Apr 9, 2020

Filed:

Sep 26, 2019

Appl. No.:

16/584353

Inventors:

- San Diego CA, US
Kay Klausing - San Diego CA, US
Bradley Kent Drews - Poway CA, US
Nicholas Watson - San Diego CA, US
Jennifer Olivia Foley - San Diego CA, US
Murphy Hitchcock - San Diego CA, US
Paul Sangiorgio - San Diego CA, US

Assignee:

Illumina, Inc. - San Diego CA

International Classification:

B01L 3/00

Abstract:

A system includes a fluidic device, a flow control valve, a first reagent fluid reservoir fluidly connectable to the fluidic device by the flow control valve, a first fluid buffer reservoir fluidly connectable to the fluidic device by the flow control valve, and a common fluid buffer source fluidly connectable to the fluidic device by the flow control valve. The flow control valve permits flow comprising: (i) flow from the first reagent fluid reservoir to the fluidic device, (ii) flow from the common fluid buffer source to the fluidic device, (iii) flow from the fluidic device to the first fluid buffer reservoir, (iv) flow from the first reagent fluid reservoir to the fluidic device, and (v) flow from the first fluid buffer reservoir to the fluidic device.

US Patent:

20190351413, Nov 21, 2019

Filed:

May 2, 2019

Appl. No.:

16/401805

Inventors:

- San Diego CA, US
Minsoung RHEE - San Diego CA, US
Jeffrey LIU - San Diego CA, US
Paul CRIVELLI - San Diego CA, US
Jennifer FOLEY - San Diego CA, US
Darren SEGALE - San Diego CA, US
Jay TAYLOR - San Diego CA, US
Matthew HAGE - San Diego CA, US
Philip PAIK - San Diego CA, US
Erik ALLEGOREN - San Diego CA, US
David HERTZOG - San Diego CA, US
Xiaoxiao MA - San Diego CA, US
Tsukasa TAKAHASHI - San Diego CA, US
Brandon WESTERBERG - San Diego CA, US

Assignee:

Illumina, Inc. - San Diego CA

International Classification:

B01L 3/00

Abstract:

An instrument includes a reagent management system. The reagent management system includes a plurality of reagent wells, each reagent well operable to contain a reagent of a plurality of reagents positioned therein. The reagent management system is operable to select a flow of reagent from one of the plurality of reagents. A flexible connection includes a laminate stack and includes a first flexible channel in fluid communication with the reagent management system. The first flexible channel is operable to route the flow of reagent therethrough. A flow cell includes a flow channel in fluid communication with the first flexible channel. The flow channel is operable to route the flow of reagent over analytes positioned in the flow channel. The flexible connection enables the flow cell to be moved by the instrument relative to a fixed reference point in the instrument.

US Patent:

20190336970, Nov 7, 2019

Filed:

May 1, 2019

Appl. No.:

16/400629

Inventors:

- San Diego CA, US
Jay TAYLOR - San Diego CA, US
Minsoung RHEE - San Diego CA, US
Jennifer FOLEY - San Diego CA, US
Cyril DELATTRE - San Diego CA, US
Tarun KHURANA - San Diego CA, US
Paul CRIVELLI - San Diego CA, US

Assignee:

Illumina, Inc. - San Diego CA

International Classification:

B01L 3/00
G01N 21/05

Abstract:

In one example, a flow cell includes a plurality of inlet ports sized to receive a flow of reagent from one of a plurality of reagents into the flow cell. An outlet port of the flow cell is sized to pass each flow of reagent out of the flow cell. A flow channel of the flow cell is positioned between, and in fluid communication with, each inlet port and the outlet port. The flow channel includes a manifold section and a detection section. The manifold section has a plurality of manifold branches in fluid communication with a common line, wherein each branch is connected to one of each inlet port. The detection section is in fluid communication with the common line and the outlet port. The detection section is operable to perform a plurality of different chemical reactions between the plurality of reagents and analytes positioned in the detection section.

US Patent:

20190224676, Jul 25, 2019

Filed:

Jan 10, 2019

Appl. No.:

16/244776

Inventors:

- San Diego CA, US
- Cambridge, GB
Oliver Jon MILLER - Cambridge, GB
Jennifer Olivia FOLEY - San Diego CA, US
Tarun Kumar KHURANA - San Diego CA, US
Paul CRIVELLI - San Diego CA, US
Gary WATTS - San Diego CA, US

Assignee:

Illumina, Inc. - San Diego CA
Illumina Cambridge Limited - Cambridge

International Classification:

B01L 3/00
G01N 1/31

Abstract:

An apparatus for directing fluid into and out of a fluidic device includes two or more fluid prime channels connected to a fluid inlet of the fluidic device, a flow control valve for each fluid prime channel to control flow between the fluid prime channel and the fluid inlet, one or more outlet channels connected to a fluid outlet of the fluidic device, and a flow control valve for each outlet channel to control flow between the fluid outlet and the associated outlet channel. An apparatus for delivering fluids to a fluid inlet includes a plate that is rotatable about an axis of rotation and a plurality of fluid compartments disposed on the plate, each compartment having a fluid exit port disposed at a common radial distance from the axis of rotation and positioned to align with the fluid inlet as the plate rotates about the axis of rotation.

US Patent:

20160199832, Jul 14, 2016

Filed:

Aug 29, 2014

Appl. No.:

14/912394

Inventors:

- San Diego CA, US
- Parvis Louis Neel, FR
Alex Aravanis - Hayward CA, US
Cyril Delattre - Grenoble, FR
Arnaud Rival - Grenoble, FR
Jennifer Foley - San Diego CA, US
Poorya Sabounchi - Hayward CA, US
Tarun Khurana - Hayward CA, US
Majid Babazadeh - Hayward CA, US
Hamed Amini - San Diego CA, US
Bala Murali Venkatesan - San Diego CA, US
M. Shane Bowen - San Diego CA, US
Steven M. Barnard - San Diego CA, US
Maria Candelaria Rogert Bacigalupo - San Diego CA, US
Dietrich Dehlinger - Hayward CA, US

Assignee:

Advanced Liquid Logic France SAS - Grenoble

International Classification:

B01L 3/00

Abstract:

Provided herein is a droplet actuator including (a) first and second substrates separated by a droplet-operations gap, the first and second substrates including respective hydrophobic surfaces that face the droplet-operations gap; (b) a plurality of electrodes coupled to at least one of the first substrate and the second substrate, the electrodes arranged along the droplet-operations gap to control movement of a droplet along the hydrophobic surfaces within the droplet-operations gap; and (c) a hydrophilic or variegated-hydrophilic surface exposed to the droplet-operations gap, the hydrophilic or variegated-hydrophilic surface being positioned to contact the droplet when the droplet is at a select position within the droplet-operations gap.