Jennifer W Freeman

US Patent:

6921821, Jul 26, 2005

Filed:

Jun 11, 2003

Appl. No.:

10/459682

Inventors:

Christopher Blackburn - Natick MA, US
Su-Jen Lai - Somerville MA, US
Jennifer L. Che - Cambridge MA, US
Martin P. Maguire - Woburn MA, US
Michael A. Patane - Andover MA, US
Matthew J. LaMarche - Reading MA, US
Courtney A. Cullis - Belmont MA, US
James Brown - Framingham MA, US
Anil Vasudevan - Gurnee IL, US
Jennifer C. Freeman - Grayslake IL, US
Mathew M. Mulhern - Hainesville IL, US
John K. Lynch - Kenosha WI, US
Ju Gao - Gurnee IL, US
Dariusz Wodka - Waukegan IL, US
Andrew J. Souers - Evanston IL, US
Rajesh Iyengar - Lindenhurst IL, US
Mary Katherin Verzal - Burlington WI, US
Philip R. Kym - Grayslake IL, US

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

C07D205/08
C07D401/00
C07D239/02

US Classification:

540364, 540601, 544284, 544324, 546157, 514312

Abstract:

This invention provides compounds that are antagonists of melanin concentrating hormone receptor-1 (MCH-R1). The compounds are represented by formula I: where m is zero or one, n is zero to two, Y is oxygen or —N(R)—, R, R, R, R, R, Rand Ring A are defined in the specification. Coumarin and quinolone compounds where Rand Rtogether form a fused benzo ring are preferred. The invention also provides compounds of formula VI where the coumarin moiety is replaced by a quinazolinone ring. The compounds are useful for treating MCH-R1-related disorders, particularly overweight conditions including obesity.

US Patent:

20150335331, Nov 26, 2015

Filed:

May 21, 2015

Appl. No.:

14/718175

Inventors:

- Ann Arbor MI, US
Jennifer Freeman - Cambridge MA, US
Daniel H. Teitelbaum - Ann Arbor MI, US
Diann Erbschloe Brei - Milford MI, US
Jonathan E. Luntz - Ann Arbor MI, US
Yumi Fukatsu - Tokyo, JP
Farokh R. Demehri - Ann Arbor MI, US

International Classification:

A61B 17/11
A61B 17/12
A61M 29/02

Abstract:

An attachment system for selectively attaching to an interior surface of a hollow member, which includes an expanding device selectively enlargeable from a first size position to an enlarged second size position, a friction enhancement disposed about the expanding device that is engageable with the interior surface of the hollow member when the expanding device is in the enlarged position, and a fenestrated decoupling system extending between at least a portion of the friction enhancement of the expanding device and the interior surface of the hollow member. The fenestrated decoupling system generally prevents contact of the friction enhancement with the interior surface of the hollow member when the expanding device is in the first size position and permits contact of the friction enhancement with the interior surface of the hollow member when the expanding device is in the enlarged position.