Jennifer D Freeman

US Patent:

20230029009, Jan 26, 2023

Filed:

Sep 6, 2022

Appl. No.:

17/903216

Inventors:

- Durham NC, US
Brent Christopher BECK - Apex NC, US
Bharathi PANDI - Cary NC, US
Jennifer C. FREEMAN - Durham NC, US

International Classification:

C07D 487/04
C07D 471/04
A61K 45/06

Abstract:

The present disclosure describes novel compounds, or their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and their medical uses. The compounds of the disclosure have activity as prostaglandin EP4 receptor antagonists, and are useful in the treatment or alleviation of pain and inflammation and other inflammation-associated disorders, such as arthritis, treating or preventing disorders or medical conditions selected from pain, inflammatory diseases and the like. Also described herein are methods of treating pain by administering the compounds of the disclosure, which are EP4 receptor antagonists.

US Patent:

20200270257, Aug 27, 2020

Filed:

Jan 29, 2020

Appl. No.:

16/775596

Inventors:

- Durham NC, US
Brent Christopher BECK - Apex NC, US
Bharathi PANDI - Cary NC, US
Jennifer C. FREEMAN - Durham NC, US

International Classification:

C07D 487/04
C07D 471/04

Abstract:

The present disclosure describes novel compounds, or their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and their medical uses. The compounds of the disclosure have activity as prostaglandin EP4 receptor antagonists, and are useful in the treatment or alleviation of pain and inflammation and other inflammation-associated disorders, such as arthritis, treating or preventing disorders or medical conditions selected from pain, inflammatory diseases and the like. Also described herein are methods of treating pain by administering the compounds of the disclosure, which are EP4 receptor antagonists.