Jennifer L Gage

US Patent:

7786139, Aug 31, 2010

Filed:

May 20, 2008

Appl. No.:

12/124051

Inventors:

John E. Bergmann - Mercer Island WA, US
Neil S. Cutshall - Snohomish WA, US
Rene Onrust - Mercer Island WA, US
Hongkui Zeng - Shoreline WA, US
Jennifer Lynn Gage - Kenmore WA, US
Derek Johnston - Glasgow, GB
Sándor Cseh - Dunakeszi, HU
László Ürögdi - Budapest, HU
Ákos Papp - Budapest, HU

Assignee:

Omeros Corporation - Seattle WA

International Classification:

A01N 43/42
A61K 31/47
C07D 215/00

US Classification:

514311, 514312, 546152

Abstract:

Compounds that inhibit PDE10 are disclosed that have utility in the treatment of a variety of conditions, including (but not limited to) psychotic, anxiety, movement disorders and/or neurological disorders such as Parkinson's disease, Huntington's disease, Alzheimer's disease, encephalitis, phobias, epilepsy, aphasia, Bell's palsy, cerebral palsy, sleep disorders, pain, Tourette syndrome, schizophrenia, delusional disorders, drug-induced psychosis and panic and obsessive-compulsive disorders. The compounds have the general structure:.

US Patent:

7829737, Nov 9, 2010

Filed:

Mar 6, 2008

Appl. No.:

12/043872

Inventors:

Mark Arnold Thomas Blaskovich - Bardon, AU
Ted Baughman - Bothell WA, US
Thomas Little - Redmond WA, US
Maher Qabar - Sammamish WA, US
Lauri Marie Schultz - Batavia WA, US
Feng Hong - Bellevue WA, US
William Patt - Lawrence KS, US
Gangadhar Nagula - Bothell WA, US
Jennifer Lynn Gage - Kenmore WA, US
James Jeffry Howbert - Bellevue WA, US

Assignee:

Ceptyr, Inc. - Bothell WA

International Classification:

C07F 9/02

US Classification:

558190, 558 89

Abstract:

The present invention provides compounds of Formula (I) and Formula (II) that are useful for modulating the biological activity of the protein tyrosine phosphatase-1b (PTP1B) enzyme. Compounds of this invention can be used to treat diseases and/or conditions in which the PTP1B enzyme is a factor. Such diseases and/or conditions include, but are not limited to, Type 1 diabetes, Type 2 diabetes, inadequate glucose tolerance, insulin resistance, obesity, hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, low HDL levels, atherosclerosis, vascular restenosis, inflammatory bowel disease, pancreatitis, adipose cell tumors, adipose cell carcinoma, liposarcoma, dyslipidemia, cancer, and neurodegenerative diseases.

US Patent:

8278327, Oct 2, 2012

Filed:

Aug 2, 2010

Appl. No.:

12/848766

Inventors:

John E. Bergmann - Mercer Island WA, US
Neil S. Cutshall - Snohomish WA, US
Rene Onrust - Mercer Island WA, US
Hongkui Zeng - Shoreline WA, US
Jennifer Lynn Gage - Kenmore WA, US
Derek Johnston - Glasgow, GB
Sándor Cseh - Dunakeszi, HU
László Ürögdi - Budapest, HU
Ákos Papp - Budapest, HU

Assignee:

Omeros Corporation - Seattle WA

International Classification:

A01N 43/42
A61K 31/47
C07D 215/00

US Classification:

514311, 514312, 546152

Abstract:

Compounds that inhibit PDE10 are disclosed that have utility in the treatment of a variety of conditions, including (but not limited to) psychotic, anxiety, movement disorders and/or neurological disorders such as Parkinson's disease, Huntington's disease, Alzheimer's disease, encephalitis, phobias, epilepsy, aphasia, Bell's palsy, cerebral palsy, sleep disorders, pain, Tourette syndrome, schizophrenia, delusional disorders, drug-induced psychosis and panic and obsessive-compulsive disorders. The compounds have the general structure:.

US Patent:

8299307, Oct 30, 2012

Filed:

Jun 30, 2008

Appl. No.:

12/217022

Inventors:

Ian Leslie Scott - Monroe WA, US
Vladimir Aleksandrovich Kuksa - Seattle WA, US
Mark W Orme - Seattle WA, US
Thomas Little - Redmond WA, US
Anna Gall - Woodinville WA, US
Jennifer Gage - Kenmore WA, US
Feng Hong - Bellevue WA, US

Assignee:

Acucela Inc. - Seattle WA

International Classification:

C07C 211/00
C07C 217/00
C07C 213/00

US Classification:

564374, 564354, 564363

Abstract:

Provided are alkynyl phenyl derivative compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.

US Patent:

8343970, Jan 1, 2013

Filed:

Mar 10, 2011

Appl. No.:

13/045162

Inventors:

Neil S. Cutshall - Snohomish WA, US
Jennifer Lynn Gage - Kenmore WA, US
Thomas Neil Wheeler - Raleigh NC, US
Thomas L. Little - Redmond WA, US

Assignee:

Omeros Corporation - Seattle WA

International Classification:

A61K 31/5377
A61K 31/497
A61K 31/4709
A61K 31/4545
A61K 31/454
A61K 31/4535
A61K 31/4525
A61K 31/444
A61K 31/4439
A61K 31/4436
A61K 31/443
A61K 31/426
A61K 31/4245
A61K 31/421
A61K 31/4196
A61K 31/4192
A61K 31/4164
A61K 31/4155
A61K 31/34
C07D 417/10
C07D 413/14
C07D 413/10
C07D 405/06
C07D 407/14
C07D 407/10
C07D 407/06
C07D 307/46
C07D 263/32
C07D 231/12

US Classification:

5142368, 5142315, 514364, 514365, 514461, 514363, 514406, 514359, 514374, 5142365, 51425505, 514382, 514318, 514314, 514372, 544152, 544148, 544405, 544131, 544111, 544140, 544134, 544138, 548136, 548143, 5483657, 548255, 548236, 5483741, 548253, 548261, 548214, 548204, 5462847, 546194, 546174, 549473, 549498

Abstract:

Compounds that inhibit PDE10 are disclosed that have utility in the treatment of a variety of conditions, including (but not limited to) psychotic, anxiety, movement disorders and/or neurological disorders such as Parkinson's disease, Huntington's disease, Alzheimer's disease, encephalitis, phobias, epilepsy, aphasia, Bell's palsy, cerebral palsy, sleep disorders, pain, Tourette's syndrome, schizophrenia, delusional disorders, drug-induced psychosis and panic and obsessive-compulsive disorders. Pharmaceutically acceptable salts, stereoisomers, solvates and prodrugs of the compounds are also provided. Also disclosed are compositions containing a compound in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for inhibiting PDE10 in a warm-blooded animal in need of the same.

US Patent:

8377930, Feb 19, 2013

Filed:

Aug 4, 2009

Appl. No.:

12/535598

Inventors:

Neil S. Cutshall - Snohomish WA, US
Jennifer Lynn Gage - Kenmore WA, US
Thomas Neil Wheeler - Raleigh NC, US

Assignee:

Omeros Corporation - Seattle WA

International Classification:

A61K 31/536
A61K 31/47
C07D 215/12
C07D 265/36

US Classification:

5142298, 514311, 514451, 544106, 549545, 546112

Abstract:

Compounds that inhibit PDE10 are disclosed that have utility in the treatment of a variety of conditions, including (but not limited to) psychotic, anxiety, movement disorders and/or neurological disorders such as Parkinson's disease, Huntington's disease, Alzheimer's disease, encephalitis, phobias, epilepsy, aphasia, Bell's palsy, cerebral palsy, sleep disorders, pain, Tourette's syndrome, schizophrenia, delusional disorders, drug-induced psychosis and panic and obsessive-compulsive disorders. Pharmaceutically acceptable salts, stereoisomers, solvates and prodrugs of the compounds are also provided. Also disclosed are compositions containing a compound in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for inhibiting PDE10 in a warm-blooded animal in need of the same.

US Patent:

8389771, Mar 5, 2013

Filed:

Aug 3, 2011

Appl. No.:

13/197659

Inventors:

Ian Leslie Scott - Monroe WA, US
Vladimir Aleksandrovich Kuksa - Seattle WA, US
Mark W. Orme - Seattle WA, US
Thomas Little - Redmond WA, US
Anna Gall - Woodinville WA, US
Jennifer Gage - Kenmore WA, US
Feng Hong - Bellevue WA, US

Assignee:

Acucela, Inc. - Bothell WA

International Classification:

C07C 211/00
C07C 217/00
C07C 215/00

US Classification:

564374, 564354, 564363

Abstract:

Provided are alkynyl phenyl derivative compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.

US Patent:

8420863, Apr 16, 2013

Filed:

Jan 27, 2012

Appl. No.:

13/360285

Inventors:

Ian Leslie Scott - Monroe WA, US
Vladimir Aleksandrovich Kuksa - Seattle WA, US
Anna Gall - Woodinville WA, US
Mark W. Orme - Seattle WA, US
Jennifer Gage - Kenmore WA, US
Qin Jiang - Latham NY, US
Lana Michele Rossiter - Clifton Park NY, US
Ryo Kubota - Seattle WA, US

Assignee:

Acucela, Inc. - Bothell WA

International Classification:

C07C 211/03
A61K 31/135

US Classification:

564383, 514654

Abstract:

The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are styrenyl derivative compounds, including but not limited to stilbene derivative compounds, and compositions comprising these compounds, that are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.