Jennifer A Vance

US Patent:

7655641, Feb 2, 2010

Filed:

Feb 10, 2004

Appl. No.:

10/542579

Inventors:

Scott Eugene Conner - Indianapolis IN, US
Lynn Stacy Gossett - Indianapolis IN, US
Jonathan Edward Green - Avon IN, US
Nathan Bryan Mantlo - Brownsburg IN, US
Donald Paul Matthews - Indianapolis IN, US
Daniel Ray Mayhugh - Carmel IN, US
Daryl Lynn Smith - Fishers IN, US
Jennifer Ann Vance - San Jose CA, US
Xiaodong Wang - Carmel IN, US
Alan M Warshawsky - Carmel IN, US
Yanping Xu - Fishers IN, US
Guoxin Zhu - Noblesville IN, US

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

A61K 31/66
A61K 31/38
C07D 409/12
C07D 209/04

US Classification:

514141, 514443, 548467, 549 51, 549 52, 549 54, 549 55

Abstract:

The present invention is directed to a compound of Formula (I): and pharmaceutically acceptable salts, solvates, hydrates or stereoisomers thereof, which are useful in treating or preventing disorders mediated by a peroxisome proliferator activated receptor (PPAR) such as syndrome X, type II diabetes, hyperglycemia, hyperlipidemia, obesity, coagaulopathy, hypertension, arteriosclerosis, and other disorders related to syndrome X and cardiovascular diseases.

US Patent:

7723531, May 25, 2010

Filed:

Dec 20, 2006

Appl. No.:

11/792770

Inventors:

George Wu - Basking Ridge NJ, US
Frank X. Chen - Plainsboro NJ, US
Paitoon Rashatasakhon - Samutsakhon, TH
Jeffrey M. Eckert - Hazlet NJ, US
George S. K. Wong - Summit NJ, US
Hong-Chang Lee - Livingston NJ, US
Nolan C. Erickson - West Orange NJ, US
Jennifer Ann Vance - Scotch Plains NJ, US
Peter C. Nirchio - Lebanon NJ, US
Juergen Weber - East Windsor NJ, US
David Jieh-Shyh Tsai - Warren NJ, US
Nanfei Zou - East Brunswick NJ, US

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

C07D 209/52

US Classification:

548515, 548452

Abstract:

The present invention provides for a process for preparing racemic methyl 6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylate, its corresponding salt: (2S, 3R, 4S)-methyl 6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylate di-p-toluoyl-D-tartaric acid (“D-DTTA”) salt or a (2R, 3S, 4R)-methyl 6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylate di-p-toluoyl-L-tartaric acid salt (“L-DTTA”) in a high enantiomeric excess. This invention also provides for a process for preparing a (2S, 3R, 4S)-methyl 6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylate dibenzoyl-D-tartaric acid (“D-DBTA”) salt or a (2R, 3S, 4R)-methyl 6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylate L-tartaric acid (“L-DBTA”) salt in a high enantiomeric excess. Further, this invention provides a process for preparing intermediates II, IIB, III, IV, IV salt, V, VI, and VII.

US Patent:

8163937, Apr 24, 2012

Filed:

Dec 18, 2007

Appl. No.:

12/519485

Inventors:

George S. K. Wong - Summit NJ, US
Hong-Chang Lee - Livingston NJ, US
Jennifer A. Vance - Scotch Plains NJ, US
Weidong Tong - Mountainside NJ, US
Tetsuo Iwama - Scotch Plains NJ, US

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

C07D 209/52

US Classification:

548515

Abstract:

The present invention relates also to a process for the preparation of intermediate compounds useful in preparing the compounds of Formula (I) using the process of Scheme (II).

US Patent:

8198463, Jun 12, 2012

Filed:

Apr 9, 2010

Appl. No.:

12/757322

Inventors:

George Wu - Basking Ridge NJ, US
Frank X. Chen - Plainsboro NJ, US
Paitoon Rashatasakhon - Samutsakhon, TH
Jeffrey M. Eckert - Hazlet NJ, US
George S. K. Wong - Summit NJ, US
Hong-Chang Lee - Livingston NJ, US
Nolan C. Erickson - West Orange NJ, US
Jennifer Ann Vance - Scotch Plains NJ, US
Peter C. Nirchio - Lebanon NJ, US
Juergen Weber - East Windsor NJ, US
David Jieh-Shyh Tsai - Warren NJ, US
Nanfei Zou - East Brunswick NJ, US

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

C07D 209/52

US Classification:

548515, 548452

Abstract:

The present invention provides for a process for preparing racemic methyl 6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylate, its corresponding salt: (1R,2S,5S)-methyl 6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylate di-p-toluoyl-D-tartaric acid (“D-DTTA”) salt or a (1S,2R,5R)-methyl 6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylate di-p-toluoyl-L-tartaric acid salt (“L-DTTA”) in a high enantiomeric excess. This invention also provides for a process for preparing a (1R,2S,5S)-methyl 6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylate dibenzoyl-D-tartaric acid (“D-DBTA”) salt or a (1S,2R,5R)-methyl 6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylate L-tartaric acid (“L-DBTA”) salt in a high enantiomeric excess. Further, this invention provides a process for preparing intermediates II, IIB, III, IV, IV salt, V, VI, and VII.

US Patent:

20050075378, Apr 7, 2005

Filed:

May 24, 2002

Appl. No.:

10/477405

Inventors:

Lynn Gossett - Indianapolis IN, US
Jonathan Green - Greencastle IN, US
James Henry - Indianapolis IN, US
Winton Jones - Carmel IN, US
Donald Matthews - Indianapolis IN, US
Quanrong Shen - Fishers IN, US
Daryl Smith - Fishers IN, US
Jennifer Vance - San Jose CA, US
Alan Warshawsky - Carmel IN, US
Maria Gonzalez-Garcia - Madrid, ES

International Classification:

C07D277/18
C07D263/52
A61K031/426
A61K031/421
A61K031/4164

US Classification:

514365000, 514374000, 514396000, 514541000, 548200000, 548217000, 548335100

Abstract:

The present invention is directed to a compound of formula I, and pharmaceutically acceptable salts, solvates, hydrates or stereoisomer thereof, which are useful in treating Syndrome X, Type II diabetes, hyperglycemia, hyperlipidemia, obesity, coagaulopathy, hypertension, arteriosclerosis, and other disorders related to Syndrome X as well as cardiovascular diseases.

US Patent:

20080167310, Jul 10, 2008

Filed:

Oct 3, 2007

Appl. No.:

11/866568

Inventors:

Lynn Stacy Gossett - Indianapolis IN, US
Jonathan Edward Green - Greencastle IN, US
James Robert Henry - Indianapolis IN, US
Winton Dennis Jones - Carmel IN, US
Donald Paul Matthews - Indianapolis IN, US
Quanrong Shen - Fishers IN, US
Daryl Lynn Smith - Fishers IN, US
Jennifer Ann Vance - San Jose CA, US
Alan M. Warshawsky - Carmel IN, US
Maria Rosario Gonzalez-Garcia - Madrid, ES

International Classification:

A61K 31/5377
C07D 413/02
C07D 277/38
A61K 31/421
A61P 3/06
A61P 3/10
A61K 31/426
C07D 263/30

US Classification:

5142368, 544137, 548193, 548235, 514370, 514374

Abstract:

The present invention is directed to a compound of formula I, and pharmaceutically acceptable salts, solvates, hydrates or stereoisomer thereof, which are useful in treating Syndrome X, Type II diabetes, hyperglycemia, hyperlipidemia, obesity, coagaulopathy, hypertension, arteriosclerosis, and other disorders related to Syndrome X as well as cardiovascular diseases.