Jennifer Carrie Webster

US Patent:

20090249498, Oct 1, 2009

Filed:

Apr 21, 2008

Appl. No.:

12/148728

Inventors:

Dietrich A. Stephan - Phoenix AZ, US
Eric M. Reiman - Scottsdale AZ, US
Jennifer Webster - Phoenix AZ, US
Christopher B. Heward - Mesa AZ, US
Pamela Heward - Mesa AR, US
Andreas Papassotiropoulos - Zurich, CH

Assignee:

TRANSLATIONAL GENOMICS RESEARCH INSTITUTE - Phoenix AZ
KRONOS SCIENCE LABORATORY - Phoenix AZ

International Classification:

C12Q 1/68
C07H 21/04
A01K 67/027
G01N 33/00

US Classification:

800 3, 435 6, 536 2431, 800 13

Abstract:

The present disclosure relates to genetic markers and methods of diagnosing and screening for late-onset Alzheimer's disease (LOAD). As such, the disclosure encompasses a whole-genome association analysis of single nucleotide polymorphisms (SNPs) of which a number are located within the GRB2-associated binding protein 2 (GAB2) gene as well as other markers associated with other genes. The disclosure identifies two novel haplotypes within the GAB2 gene, i.e., a LOAD risk-enhancing and a LOAD risk-decreasing haplotype. These haplotypes modify LOAD risk differentially in combination with APOE alleles. Further encompassed are therapeutic methods and agents of decreasing the deterioration of cells associated with LOAD.